2-Deoxy-D-glucose

Name: 2-Deoxy- D -glucose
Brand: Tocris Bioscience
SKU: 4515
Rating: 5 (4 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4515

(4)

Citations (24)

COA / SDS

Non-metabolizable glucose analog; inhibits glucose metabolism

Key Product Details

Description:	Non-metabolizable glucose analog; inhibits glucose metabolism
Chemical Name:	2-Deoxy-D-arabino-hexose
Molecular Weight:	164.16

View Full Technical Details for 2-Deoxy-D-glucose

Technical Data
Citations / Reviews (4)

Biological Activity for 2-Deoxy-D-glucose

2-Deoxy-D-glucose is a non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR). 2-Deoxy-D-glucose disrupts N-glycan expression on the surface of pancreatic adenocarcinoma cells. 2-Deoxy-D-glucose enhances chimeric antigen receptor T cell activity in different xenograft mouse models of pancreatic adenocarcinoma cells.

Technical Data for 2-Deoxy-D-glucose

M. Wt	164.16
Formula	C₆H₁₂O₅
Storage	Store at +4°C
CAS Number	154-17-6
PubChem ID	439268
InChi Key	PMMURAAUARKVCB-CERMHHMHSA-N
Smiles	OC1C[C@@H](O)[C@H](O)[C@@H](CO)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-Deoxy-D-glucose

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	16.42	100
	DMSO	16.42	100

Preparing Stock Solutions for 2-Deoxy-D-glucose

The following data is based on the product molecular weight 164.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.09 mL	30.46 mL	60.92 mL
5 mM	1.22 mL	6.09 mL	12.18 mL
10 mM	0.61 mL	3.05 mL	6.09 mL
50 mM	0.12 mL	0.61 mL	1.22 mL

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Reconstitution Calculator

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References for 2-Deoxy-D-glucose

References are publications that support the biological activity of the product.

Greco Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies. Sci.Transl.Med. 2022 PMID: 35044789
Maher Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother.Pharmacol. 2004 PMID: 14605866
Ralser A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth. Proc.Natl.Acad.Sci.USA 2008 PMID: 19004802
Kang and Hwang 2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci. 2006 PMID: 16111712