Key Product Details
Description: | Highly selective A3 agonist |
Chemical Name: | 1-[2-Chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 544.74 |
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Citations for 2-Cl-IB-MECA (13)
Citations are publications that use Bio-Techne products. Selected citations for 2-Cl-IB-MECA include:
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Angelantonio et al.
(2015)
Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
Sci Rep.
9:409
PMID: 26528137 -
Ren et al.
(2015)
An adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-κB signaling pathway.
J Neurosci.
5:9047
PMID: 25762375 -
Iannone et al.
(2014)
Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model.
EMBO Rep.
4:172
PMID: 24660106 -
Vincenzi et al.
(2013)
Pulsed electromagnetic fields increased the anti-inflammatory effect of A2A and A3 adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts.
PLoS One.
8:e65561
PMID: 23741498 -
Corriden et al.
(2013)
Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes.
Biochim Biophys Acta.
14:726
PMID: 23817552 -
Montinaro et al.
(2012)
Adoptive immunotherapy with Cl-IB-MECA-treated CD8+ T cells reduces melanoma growth in mice.
PLoS One.
7:e45401
PMID: 23028986 -
Kan et al.
(2012)
Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
J Virol.
86:10338
PMID: 22787201 -
Rosito et al.
(2012)
CXCL16 orchestrates adenosine A3 receptor and MCP-1/CCL2 activity to protect neurons from excitotoxic cell death in the CNS.
Neoplasia.
32:3154
PMID: 22378888 -
Morello et al.
(2011)
NK1.1 cells and CD8 T cells mediate the antitumor activity of Cl-IB-MECA in a mouse melanoma model.
Am J Cancer Res.
13:365
PMID: 21472141 -
Jinka et al.
(2011)
Season primes the brain in an arctic hibernator to facilitate entrance into torpor mediated by adenosine A(1) receptors.
J Neurosci.
31:10752
PMID: 21795527 -
Bhanu et al.
(2008)
Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives.
J Pharmacol Exp Ther.
1782:504
PMID: 18586086 -
Germack and Dickenson
(2004)
Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes.
Br J Pharmacol.
141:329
PMID: 14751870 -
Man et al.
(2003)
Alteration of the purinergic modulation of enteric neurotransmission in the mouse ileum during chronic intestinal inflammation.
Br J Pharmacol.
139:172
PMID: 12746236
There are no citations that match your criteria.