2-Chloroadenosine

Name: 2-Chloroadenosine
Brand: Tocris Bioscience
SKU: 3136

Tocris Bioscience a Bio-Techne Brand

Catalog # 3136

Citations (1)

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Key Product Details

Description:	Adenosine receptor agonist
Alternative Names:	2-CADO
Chemical Name:	6-Amino-2-chloropurine riboside
Purity:	≥98% (HPLC)
Molecular Weight:	301.69

View Full Technical Details for 2-Chloroadenosine

Biological Activity for 2-Chloroadenosine

2-Chloroadenosine is a metabolically stable analog of adenosine that behaves as an adenosine receptor agonist (K_i values are 300, 80 and 1900 nM for A₁, A_2A and A₃ receptors respectively). Anticonvulsive in vivo.

Compound Libraries for 2-Chloroadenosine

2-Chloroadenosine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 2-Chloroadenosine

M. Wt	301.69
Formula	C₁₀H₁₂ClN₅O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	146-77-0
PubChem ID	8974
InChi Key	BIXYYZIIJIXVFW-UUOKFMHZSA-N
Smiles	O[C@@H]1[C@@H](CO)O[C@@H](N3C2=NC(Cl)=NC(N)=C2N=C3)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-Chloroadenosine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	7.54	25
	DMSO	30.17	100

Preparing Stock Solutions for 2-Chloroadenosine

The following data is based on the product molecular weight 301.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.31 mL	16.57 mL	33.15 mL
5 mM	0.66 mL	3.31 mL	6.63 mL
10 mM	0.33 mL	1.66 mL	3.31 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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Reconstitution Calculator

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References for 2-Chloroadenosine

References are publications that support the biological activity of the product.

Pourgholami Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures. Brain Res. 1997 PMID: 9439826
Abdul-Ghani The protective effect of 2-chloroadenosine against the development of amygdala kindling and on amygdala-kindled seizures. Eur.J.Pharmacol. 1997 PMID: 9178649
Mathot Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A₁ and A_2a receptors in vivo. Br.J.Pharmacol. 1996 PMID: 8735640

Citations for 2-Chloroadenosine (1)

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Citations are publications that use Bio-Techne products. Selected citations for 2-Chloroadenosine include:

Nowak et al. (2010) The A2aR adenosine receptor controls cytokine production in iNKT cells. Front Cell Neurosci. 40:682
PMID: 20039304

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Product Documents for 2-Chloroadenosine

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.