2-BFI hydrochloride

Name: 2-BFI hydrochloride
Brand: Tocris Bioscience
SKU: 0348
Price: 188 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0348

Citations (2)

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Key Product Details

Description:	Potent, selective I₂ ligand. Putative agonist
Chemical Name:	2-(2-Benzofuranyl)-2-imidazoline hydrochloride
Molecular Weight:	222.67

View Full Technical Details for 2-BFI hydrochloride

Biological Activity for 2-BFI hydrochloride

2-BFI hydrochloride is a high affinity I₂ ligand (K_i = 9.8 nM). Putative I₂ agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

Technical Data for 2-BFI hydrochloride

M. Wt	222.67
Formula	C₁₁H₁₀N₂O.HCl
Storage	Desiccate at RT
CAS Number	89196-95-2
PubChem ID	45073465
InChi Key	RFNFFVDVGWOSNZ-UHFFFAOYSA-N
Smiles	Cl.C1CN=C(N1)C1=CC2=CC=CC=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-BFI hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for 2-BFI hydrochloride

The following data is based on the product molecular weight 222.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.49 mL	22.45 mL	44.91 mL
5 mM	0.90 mL	4.49 mL	8.98 mL
10 mM	0.45 mL	2.25 mL	4.49 mL
50 mM	0.09 mL	0.45 mL	0.90 mL

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References for 2-BFI hydrochloride

References are publications that support the biological activity of the product.

MacInnes and Duty Locomotor effects of imidazoline I₂-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway. Br.J.Pharmacol. 2004 PMID: 15545290
Sanchez-Blasquez Activation of I₂-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 2000 PMID: 10781010
Alemany Labelling of I_2B-imidazoline receptors by [³H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9228188

Citations for 2-BFI hydrochloride (2)

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Citations are publications that use Bio-Techne products. Selected citations for 2-BFI hydrochloride include:

McDonald et al. (2020) On the formation and nature of the imidazoline I₂ binding site on human monoamine oxidase-B. Pharmacol Res. 62:475
PMID: 20832472
Kim et al. (2011) Icilin-evoked behavioral stimulation is attenuated by alpha₂-adrenoceptor activation. Brain Res. 1384:110
PMID: 21315691

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