2-BFI hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0348
Potent, selective I2 ligand. Putative agonist
Key Product Details
Description
Potent, selective I2 ligand. Putative agonist
Product Description
2-BFI hydrochloride is a high affinity I2 ligand (Ki = 9.8 nM). Putative I2 agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.Product Specifications
Molecular Weight
222.67
Formula
C11H10N2O.HCl
Storage
Desiccate at RT
Chemical Name
2-(2-Benzofuranyl)-2-imidazoline hydrochloride
CAS Number
89196-95-2
PubChem ID
45073465
InChI Key
RFNFFVDVGWOSNZ-UHFFFAOYSA-N
SMILES
Cl.C1CN=C(N1)C1=CC2=CC=CC=C2O1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions
for 2-BFI hydrochloride
The following data is based on the product molecular weight 222.67
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.49 mL | 22.45 mL | 44.91 mL |
| 5 mM | 0.90 mL | 4.49 mL | 8.98 mL |
| 10 mM | 0.45 mL | 2.25 mL | 4.49 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.90 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- MacInnes and Duty Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway. Br.J.Pharmacol. 2004 PMID: 15545290
- Sanchez-Blasquez Activation of I2-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 2000 PMID: 10781010
- Alemany Labelling of I2B-imidazoline receptors by [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9228188
Product Specific Notices for 2-BFI hydrochloride
For research use only
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