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2-APB

Bio-Techne includes Tocris Bioscience | Catalog # 1224

IP3 receptor antagonist. Also TRP channel modulator
IP3 receptor antagonist. Also TRP channel modulator

Key Product Details

Description: IP3 receptor antagonist. Also TRP channel modulator
Chemical Name: 2-Aminoethoxydiphenylborane
Purity: ≥98% (HPLC)
Molecular Weight: 225.1

Citations for 2-APB (44)

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Customer Reviews for 2-APB

5 out of 5
3 Customer Ratings
5 Stars
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  • Significantly inhibits TRPM7 current
    Name: Yuyang Sun
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: sh-sy5y
    It significantly inhibits TRPM7 current. Very good.
    2-APB Serum 1224
  • 2-APB reduces store-operated Ca2+ entry in HEK293 cells
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK293
    HEK293 cells were incubated with intracellular Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 40 min, washed and kept aside for 20 min. Fura2-loaded cells were excited alternately at 340 and 380 nm and fluorescence at 510 nm was expressed as 340/380 ratio. Intracellular Ca2+ stores were depleted with 30 μM BHQ which promotes store-operated Ca2+ entry into the cells upon addition of 1 mM extracellular Ca2+. Preincubation of cells with 50 μM 2-APB for 10 min reduces this Ca2+ entry.
    2-APB Serum 1224
  • 2-APB in brains slices
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    2-APB (50uM) was applied to mouse brain slices while measuring evoked dopamine release.
    Put it into DMSO (100mM).
    2-APB Serum 1224

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Product Documents for 2-APB

Certificate of Analysis

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