2,3-DCPE hydrochloride

Name: 2,3-DCPE hydrochloride
Brand: Tocris Bioscience
SKU: 2137
Price: 124 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 2137

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Key Product Details

Description:	Selectively induces cancer cell apoptosis
Chemical Name:	2-[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	300.61

View Full Technical Details for 2,3-DCPE hydrochloride

Biological Activity for 2,3-DCPE hydrochloride

2,3-DCPE hydrochloride is a selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. IC₅₀ values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways.

Technical Data for 2,3-DCPE hydrochloride

M. Wt	300.61
Formula	C₁₁H₁₅Cl₂NO₂.HCl
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	1009555-55-8
PubChem ID	52913859
InChi Key	GFCJFYSIPRIHKT-UHFFFAOYSA-N
Smiles	Cl.OCCNCCCOC1=C(Cl)C(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2,3-DCPE hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	30.06	100

Preparing Stock Solutions for 2,3-DCPE hydrochloride

The following data is based on the product molecular weight 300.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.33 mL	16.63 mL	33.27 mL
5 mM	0.67 mL	3.33 mL	6.65 mL
10 mM	0.33 mL	1.66 mL	3.33 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

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References for 2,3-DCPE hydrochloride

References are publications that support the biological activity of the product.

Wu Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol. Cancer Res. 2004 PMID: 14871845
Zhu Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol in correlation with activation of ERK. Oncogene 2004 PMID: 15122344

Citations for 2,3-DCPE hydrochloride

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