2,3-DCPE hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2137
Selectively induces cancer cell apoptosis
Discontinued Product
2137 has been discontinued.
View all Apoptosis Inducer Compounds products.
Key Product Details
Description
Selectively induces cancer cell apoptosis
Product Description
2,3-DCPE hydrochloride is a selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways.Product Specifications
Molecular Weight
300.61
Formula
C11H15Cl2NO2.HCl
Storage
Desiccate at -20°C
Purity
≥99% (HPLC)
Chemical Name
2-[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol hydrochloride
CAS Number
1009555-55-8
PubChem ID
52913859
InChI Key
GFCJFYSIPRIHKT-UHFFFAOYSA-N
SMILES
Cl.OCCNCCCOC1=C(Cl)C(Cl)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.06 | 100 |
Preparing Stock Solutions
for 2,3-DCPE hydrochloride
The following data is based on the product molecular weight 300.61
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.33 mL | 16.63 mL | 33.27 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.65 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.33 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Zhu Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol in correlation with activation of ERK. Oncogene 2004 PMID: 15122344
- Wu Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol. Cancer Res. 2004 PMID: 14871845
Product Specific Notices for 2,3-DCPE hydrochloride
For research use only
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