17-AAG

Novus Biologicals, part of Bio-Techne | Catalog # NB110-81558

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NB110-81558
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Key Product Details

Applications

Functional Assay

Product Summary for 17-AAG

Hsp90 inhibitor. Molecular Formula C31H43N3O8. Molecular weight 585.7 g/mol. CAS No. 75747-14-7

Product Specifications

Specificity

17-AAG Compound

Application Notes

Soluble in DMSO (>50 mg/mL) or ethanol (5 mg/mL)

Scientific Data Images for 17-AAG

Product Image: 17-AAG [NB110-81558] - Chemical structure of 17-AAG (NB110-81558), a 17-AAG. Molecular Formula: C31H43N3O8. Molecular Weight: 585.7 g/mol.

Formulation, Preparation, and Storage

Concentration

Please see the protocols for proper use of this product. If no protocol is available, contact technical services for assistance.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: 17-AAG

Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5).

Additional 17-AAG Products

Product Documents for 17-AAG

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Certificate of Analysis

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Product Specific Notices for 17-AAG

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.

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