1400W dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1415
Potent, highly selective iNOS inhibitor
Product Description
1400W dihydrochloride is a slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 μM respectively). Cell-permeable and active in vivo. Neuroprotective in epilepsy models and has analgesic effects in models of mechanical and heat hypersensitivity.Product Specifications
Molecular Weight
250.17
Formula
C10H15N3.2HCl
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
N-[[3-(Aminomethyl)phenyl]methyl]-ethanimidamide dihydrochloride
CAS Number
214358-33-5
PubChem ID
2733515
InChI Key
WDJHSQZCZGPGAA-UHFFFAOYSA-N
SMILES
Cl.Cl.CC(=N)NCC1=CC=CC(CN)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.02 | 100 |
Preparing Stock Solutions
for 1400W dihydrochloride
The following data is based on the product molecular weight 250.17
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.00 mL | 19.99 mL | 39.97 mL |
| 5 mM | 0.80 mL | 4.00 mL | 7.99 mL |
| 10 mM | 0.40 mL | 2.00 mL | 4.00 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Putra Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model. Neurobiol.Dis. 2020 PMID: 30940499
- Staunton Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model. Exp.Physiol 2018 PMID: 29441689
- Parmentier Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury. Br.J.Pharmacol. 1999 PMID: 10385257
- Thomsen Selective inhibition of inducible nitric oxide inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res. 1997 PMID: 9242464
- Garvey 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J.Biol.Chem. 1997 PMID: 9030556
Product Specific Notices for 1400W dihydrochloride
For research use only
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