10-Cl-BBQ

Name: 10-Cl-BBQ
Brand: Tocris Bioscience
SKU: 6321

Tocris Bioscience a Bio-Techne Brand

Catalog # 6321

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Key Product Details

Description:	Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable
Chemical Name:	10-Chloro-7H-benzimidazo[2,1-a]benz[de]isoquinolin-7-one
Purity:	≥97% (HPLC)
Molecular Weight:	304.73

View Full Technical Details for 10-Cl-BBQ

Biological Activity for 10-Cl-BBQ

10-Cl-BBQ is a potent aryl hydrocarbon receptor (AhR) agonist, discovered as a screening hit (IC₅₀ = 2.6 nM). Directly binds CD4⁺ T cells to induce AhR-dependent Tregs. Suppresses IL-17 production and prevents insulitis in NOD mice. In vivo half llife ~ 2 hours, orally bioavailable.

Technical Data for 10-Cl-BBQ

M. Wt	304.73
Formula	C₁₈H₉ClN₂O
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	23982-76-5
PubChem ID	1778614
InChi Key	ZJESJVGSDQOZAT-UHFFFAOYSA-N
Smiles	ClC1=CC2=C(N=C3N2C(C4=CC=CC5=C4C3=CC=C5)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 10-Cl-BBQ

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	0.3	1 with gentle warming

Preparing Stock Solutions for 10-Cl-BBQ

The following data is based on the product molecular weight 304.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.01 mM	328.16 mL	1,640.80 mL	3,281.59 mL
0.05 mM	65.63 mL	328.16 mL	656.32 mL
0.1 mM	32.82 mL	164.08 mL	328.16 mL
0.5 mM	6.56 mL	32.82 mL	65.63 mL

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References for 10-Cl-BBQ

References are publications that support the biological activity of the product.

Ehrlich Activation of the aryl hydrocarbon receptor by 10-Cl-BBQ prevents insulitis and effector T cell development independently of Foxp3+ regulatory T Cells in nonobese diabetic mice. J.Immunol. 2016 PMID: 26573835
Punj Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One 2014 PMID: 24586378

Citations for 10-Cl-BBQ

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