10-Cl-BBQ

Tocris Bioscience, part of Bio-Techne | Catalog # 6321

Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable
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Key Product Details

Description

Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable

View all Aryl Hydrocarbon Receptor Agonists »

Product Description

10-Cl-BBQ is a potent aryl hydrocarbon receptor (AhR) agonist, discovered as a screening hit (IC50 = 2.6 nM). Directly binds CD4+ T cells to induce AhR-dependent Tregs. Suppresses IL-17 production and prevents insulitis in NOD mice. In vivo half llife ~ 2 hours, orally bioavailable.

Product Specifications

Molecular Weight

304.73

Formula

C18H9ClN2O

Storage

Store at +4°C

Purity

≥97% (HPLC)

Chemical Name

10-Chloro-7H-benzimidazo[2,1-a]benz[de]isoquinolin-7-one

CAS Number

23982-76-5

PubChem ID

1778614

InChI Key

ZJESJVGSDQOZAT-UHFFFAOYSA-N

SMILES

ClC1=CC2=C(N=C3N2C(C4=CC=CC5=C4C3=CC=C5)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.3 1 with gentle warming

Preparing Stock Solutions for 10-Cl-BBQ

The following data is based on the product molecular weight 304.73

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.01 mM 328.16 mL 1,640.80 mL 3,281.59 mL
0.05 mM 65.63 mL 328.16 mL 656.32 mL
0.1 mM 32.82 mL 164.08 mL 328.16 mL
0.5 mM 6.56 mL 32.82 mL 65.63 mL

Calculators

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Product Documents for 10-Cl-BBQ

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 10-Cl-BBQ

For research use only

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