1-Hex-GlcNAlk

Name: 1-Hex-GlcNAlk
Brand: Tocris Bioscience
SKU: 7751

Tocris Bioscience, part of Bio-Techne | Catalog # 7751

COA / SDS

Metabolic chemical reporter for studying glycosylation and glycoproteins

Key Product Details

Description:	Metabolic chemical reporter for studying glycosylation and glycoproteins
Chemical Name:	(2S,3R,4R,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(pent-4-ynamido)tetrahydro-2H-pyran-2-yl hexanoate
Purity:	≥95% (HPLC)
Molecular Weight:	357.4

View Full Technical Details for 1-Hex-GlcNAlk

Technical Data
Citations

Biological Activity for 1-Hex-GlcNAlk

1-Hex-GlcNAlk is a metabolic chemical reporter (MCR) for studying glycoproteins and glycosylation; it comprises GlcNAlk functionalized at the anomeric position with hexanoic acid. 1-Hex-GlcNAlk exhibits time- and concentration-dependent specific enzymatic labeling of proteins in HeLa cells, with negligible background labeling detected in cell lysates.

Technical Data for 1-Hex-GlcNAlk

M. Wt	357.4
Formula	C₁₇H₂₇NO₇
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2863607-71-8
InChi Key	PJQZXSANZZIQIK-YFTGLANFSA-N
Smiles	OC[C@H]1O[C@@H](OC(CCCCC)=O)[C@H](NC(CCC#C)=O)[C@@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 1-Hex-GlcNAlk

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.74	100

Preparing Stock Solutions for 1-Hex-GlcNAlk

The following data is based on the product molecular weight 357.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.80 mL	13.99 mL	27.98 mL
5 mM	0.56 mL	2.80 mL	5.60 mL
10 mM	0.28 mL	1.40 mL	2.80 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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Reconstitution Calculator

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References for 1-Hex-GlcNAlk

References are publications that support the biological activity of the product.

Pedowitz Anomeric fatty acid functionalization prevents nonenzymatic S-glycosylation by monosaccharide metabolic chemical reporters. ACS Chem Biol 2021 PMID: 34282887