TCS PIM-1 1
Tocris Bioscience, part of Bio-Techne | Catalog # 2979
Selective, ATP-competitive Pim-1 kinase inhibitor
Key Product Details
Description
Selective, ATP-competitive Pim-1 kinase inhibitor
Alternative Names
SC 204330
Product Description
TCS PIM-1 1 is an ATP-competitive Pim-1 kinase inhibitor that displays selectivity over Pim-2 and MEK1/2 (IC50 values are 50, > 20000 and > 20000 nM for Pim-1, Pim-2 and MEK1/2 respectively).Product Specifications
Molecular Weight
367.20
Formula
C18H11BrN2O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
CAS Number
491871-58-0
PubChem ID
1235170
InChI Key
SVSYJTYGPLVUOZ-UHFFFAOYSA-N
SMILES
OC1=C(C2=CC(C3=CC=CC=C3)=C(C#N)C(N2)=O)C=C(Br)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.72 | 100 |
Preparing Stock Solutions
for TCS PIM-1 1
The following data is based on the product molecular weight 367.20
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.72 mL | 13.62 mL | 27.23 mL |
| 5 mM | 0.54 mL | 2.72 mL | 5.45 mL |
| 10 mM | 0.27 mL | 1.36 mL | 2.72 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cheney Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg.Med.Chem.Letts. 2007 PMID: 17251021
Product Specific Notices for TCS PIM-1 1
For research use only
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