Saquinavir mesylate
Tocris Bioscience, part of Bio-Techne | Catalog # 4418
HIV protease inhibitor
Key Product Details
Description
HIV protease inhibitor
Alternative Names
Ro 31-8959
Product Description
Saquinavir mesylate is an inhibitor of human immunodeficiency virus (HIV) protease (Ki values are <0.1 and 0.12 nM for HIV-2 and HIV-1 protease respectively). Exhibits high antiviral activity and low cytotoxicity. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CLpro.Product Specifications
Molecular Weight
766.95
Formula
C38H50N6O5.CH4O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide methanesulfonate
CAS Number
149845-06-7
PubChem ID
60934
InChI Key
IRHXGOXEBNJUSN-YOXDLBRISA-N
SMILES
O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)[C@H](O)CN3C[C@](CCCC5)([H])[C@]5([H])C[C@H]3[C@@](NC(C)(C)C)=O)=O)C2=NC1=CC=CC=C1C=C2.CS(=O)(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.35 | 50 |
Preparing Stock Solutions
for Saquinavir mesylate
The following data is based on the product molecular weight 766.95
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.61 mL | 13.04 mL | 26.08 mL |
| 2.5 mM | 0.52 mL | 2.61 mL | 5.22 mL |
| 5 mM | 0.26 mL | 1.30 mL | 2.61 mL |
| 25 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Roberts Rational design of peptide-based HIV proteinase inhibitors. Science 1990 PMID: 2183354
- Tucker A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity. J.Med.Chem. 1992 PMID: 1635054
- Kaldor Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease. Bioorg.Med.Chem.Lett.
- Krausslich Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation. J.Virol. 1992 PMID: 1727499
Product Specific Notices for Saquinavir mesylate
For research use only
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