c-Di-GMP sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 5900
Endogenous STING and DDX41 agonist; activates STING-dependent signaling
Key Product Details
Description
Endogenous STING and DDX41 agonist; activates STING-dependent signaling
Product Description
c-Di-GMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes.This product is sold in units of 730μg, equivalent to 1μmol.
Product Specifications
Molecular Weight
734.37
Formula
C20H22N10Na2O14P2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3',5'-Cyclic diguanylic acid sodium salt
CAS Number
2222132-40-1
PubChem ID
101199074
InChI Key
SVIXOIGPVFFABR-XDODWTFASA-L
SMILES
O=P(O[C@H]1[C@H]([C@H](N6C=NC7=C6N=C(NC7=O)N)O[C@@H]1CO2)O)(O[Na])OC[C@@H]3[C@H]([C@H]([C@H](N4C=NC5=C4N=C(NC5=O)N)O3)O)OP2(O[Na])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.69 | 20 |
Preparing Stock Solutions
for c-Di-GMP sodium salt
The following data is based on the product molecular weight 734.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 6.81 mL | 34.04 mL | 68.09 mL |
| 1 mM | 1.36 mL | 6.81 mL | 13.62 mL |
| 2 mM | 0.68 mL | 3.40 mL | 6.81 mL |
| 10 mM | 0.14 mL | 0.68 mL | 1.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Burdette STING is a direct innate immune sensor of cyclic di-GMP. Nature 2011 PMID: 21947006
- Nakamura Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J.Control Release 2015 PMID: 26282097
- Parvatiyar The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IF. immune response. Nat.Immunol. 2012 PMID: 23142775
Product Specific Notices for c-Di-GMP sodium salt
For research use only
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