XAV 939
Tocris Bioscience, part of Bio-Techne | Catalog # 3748
Potent tankyrase inhibitor
Key Product Details
Description
Potent tankyrase inhibitor
Alternative Names
XAV939 Wnt Signaling Inhibitor
Product Description
XAV 939 is a potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the β-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyocyte differentiation in mesoderm progenitor cells. Also used in neuronal differentiation protocols (see below).XAV 939 synthesized to cGMP guidelines also available.
For more information about how XAV 939 may be used, see our protocol: Accelerated Induction of Cortical Neurons from hiPSCs
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of XAV939 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
312.31
Formula
C14H11F3N2OS
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
CAS Number
284028-89-3
PubChem ID
2726824
InChI Key
KLGQSVMIPOVQAX-UHFFFAOYSA-N
SMILES
OC1=C(CSCC2)C2=NC(C3=CC=C(C(F)(F)F)C=C3)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.25 | 20 |
Preparing Stock Solutions
for XAV 939
The following data is based on the product molecular weight 312.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 16.01 mL | 80.05 mL | 160.10 mL |
| 1 mM | 3.20 mL | 16.01 mL | 32.02 mL |
| 2 mM | 1.60 mL | 8.00 mL | 16.01 mL |
| 10 mM | 0.32 mL | 1.60 mL | 3.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Adler Inhibiting wnt signaling. Sci.Signal.
- Wang Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling. ACS Chem. Biol. 2010 PMID: 21077691
- Huang Tankyrase inhibition stabilizes axin and antagonizes wnt signalling. Nature 2009 PMID: 19759537
Product Specific Notices for XAV 939
For research use only
Loading...
Loading...
Loading...