Tertiapin-Q

Tocris Bioscience, part of Bio-Techne | Catalog # 1316

Selective blocker of inward-rectifier K+ channels
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Key Product Details

Description

Selective blocker of inward-rectifier K+ channels

View all Inward Rectifier Potassium Channel Blockers »

Product Description

Tertiapin-Q is a high affinity blocker for inward-rectifier K+ channels. Tertiapin-Q is a stable derivative of the bee venom toxin tertiapin. Tertiapin-Q binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and is selective over Kir2.1 channels. Tertiapin-Q improves heart rate and atrioventricular conduction in a mouse model of bradycardia. Derivative Tertiapin LQ (Cat. No. 4339) also available.

Licensing Information

Sold under license granted by the University of Pennsylvania

Product Specifications

Molecular Weight

2452.00

Formula

C106H175N35O24S4

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

910044-56-3

PubChem ID

90479782

InChI Key

GMZAXHIZSCRCHM-MIPBWYARSA-N

SMILES

[H]N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC3=CNC4=C3C=CC=C4)NC2=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Product Documents for Tertiapin-Q

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Tertiapin-Q

For research use only

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