Carbenoxolone disodium
Tocris Bioscience, part of Bio-Techne | Catalog # 3096
Gap junction blocker. Also inhibitor of 11 β-hydroxysteroid dehydrogenase
Key Product Details
Description
Gap junction blocker. Also inhibitor of 11 β-hydroxysteroid dehydrogenase
Product Description
Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.Product Specifications
Molecular Weight
614.72
Formula
C34H48Na2O7
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid disodium
CAS Number
7421-40-1
PubChem ID
636402
InChI Key
BQENDLAVTKRQMS-SBBGFIFASA-L
SMILES
[Na+].[Na+].[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](OC(=O)CCC([O-])=O)C(C)(C)[C@]3([H])CC[C@@]12C)C([O-])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 61.47 | 100 |
Preparing Stock Solutions
for Carbenoxolone disodium
The following data is based on the product molecular weight 614.72
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.63 mL | 8.13 mL | 16.27 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 10 mM | 0.16 mL | 0.81 mL | 1.63 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sagar and Larson Carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase A-dependent pathway. J.Cell.Biochem. 2006 PMID: 16552723
- Jellinck Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. J.Steroid Biochem.Mol.Biol. 1993 PMID: 8664169
Product Specific Notices for Carbenoxolone disodium
For research use only
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