NVP 2
Tocris Bioscience, part of Bio-Techne | Catalog # 6535
Potent and selective ATP-competitive CDK9 inhibitor
Key Product Details
Description
Potent and selective ATP-competitive CDK9 inhibitor
Product Description
NVP 2 is a potent and selective ATP-competitive CDK9 inhibitor (IC50 = 0.5 nM). Exhibits selectivity for CDK9 over a panel of 468 kinases, but inhibits DYRK1B (IC50 = 350 nM), displays <90% binding to CDK7 (IC50 >10 μM) and CDK13. Inhibits proliferation of MOLT4 cells in vitro. Induces apoptosis.Product Specifications
Molecular Weight
513.07
Formula
C27H37ClN6O2
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile
CAS Number
1263373-43-8
PubChem ID
66937006
InChI Key
XWQVQSXLXAXOPJ-QNGMFEMESA-N
SMILES
COC[C@H](N[C@H]1CC[C@H](NC2=CC(C3=NC(NCC4(C#N)CCOCC4)=CC=C3)=C(C=N2)Cl)CC1)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.31 | 100 | |
| Ethanol | 51.31 | 100 |
Preparing Stock Solutions
for NVP 2
The following data is based on the product molecular weight 513.07
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.95 mL | 9.75 mL | 19.49 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.90 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.95 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Winter BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment. Mol.Cell 2017 PMID: 28673542
- Olson Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat.Chem.Biol. 2018 PMID: 29251720
Product Specific Notices for NVP 2
For research use only
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