GW 803430
Tocris Bioscience, part of Bio-Techne | Catalog # 4242
MCH1 antagonist
Key Product Details
Description
MCH1 antagonist
Product Description
GW 803430 is a selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). Displays antiobesity and antidepressant-like effects in rats and mice. Orally active.Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline.Product Specifications
Molecular Weight
481.99
Formula
C25H24ClN3O3S
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one
CAS Number
515141-51-2
PubChem ID
9826520
InChI Key
MWULMTACIBZPGN-UHFFFAOYSA-N
SMILES
ClC(C=C3)=CC=C3C(S2)=CC1=C2C(N(C4=CC(OC)=C(OCCN5CCCC5)C=C4)C=N1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 14.75 | 25 |
Preparing Stock Solutions
for GW 803430
The following data is based on the product molecular weight 481.99
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 8.30 mL | 41.49 mL | 82.99 mL |
| 1.25 mM | 1.66 mL | 8.30 mL | 16.60 mL |
| 2.5 mM | 0.83 mL | 4.15 mL | 8.30 mL |
| 12.5 mM | 0.17 mL | 0.83 mL | 1.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gehlert Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression. J.Pharmacol.Exp.Ther. 2009 PMID: 19182070
- Rivera Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity. Curr.Med.Chem. 2008 PMID: 18393860
Product Specific Notices for GW 803430
For research use only
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