DBM 1285 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5095
p38 MAPK inhibitor; anti-inflammatory
Product Description
DBM 1285 dihydrochloride is a p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo. Attenuates zymosan-induced inflammation and adjuvant-induced arthritis in murine models. Orally active.Product Specifications
Molecular Weight
468.42
Formula
C21H22FN5S.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-(4-piperidinyl)-5-thiazolyl]-2-pyrimidinamine dihydrochloride
CAS Number
1782532-29-9
PubChem ID
90489008
InChI Key
ANQWETXPBPZVOF-UHFFFAOYSA-N
SMILES
FC(C=C4)=CC=C4C1=C(C2=CC=NC(NC5CC5)=N2)SC(C3CCNCC3)=N1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 46.84 | 100 |
Preparing Stock Solutions
for DBM 1285 dihydrochloride
The following data is based on the product molecular weight 468.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.67 mL | 21.35 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kang DBM1285 suppresses tumor necrosis factor α production by blocking p38 mitogen-activated protein kinase/mitogen-activated protein kinase-activated protein kinase 2 signaling pathway. J.Pharmacol.Exp.Ther. 2010 PMID: 20427474
Product Specific Notices for DBM 1285 dihydrochloride
For research use only
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