Simple Plex Control for Human COMP/Thrombospondin-5

Name: Simple Plex Control for Human COMP/Thrombospondin-5
Brand: ProteinSimple
SKU: 898620

ProteinSimple, part of Bio-Techne | Catalog # 898620

Product Datasheet / COA

Control for use with Human COMP/Thrombospondin-5 Simple Plex Cartridge Kit

Summary for Simple Plex Control for Human COMP/Thrombospondin-5

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human COMP/Thrombospondin-5 concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.

COMP (Cartilage Oligomeric Matrix Protein), also known as Thrombospondin-5, is a multidomain calcium binding protein that associates with other extracellular matrix molecules. COMP associates into disulfide-linked homopentamers with a central hub and peripheral globular domains connected by flexible strands. An axial pore is formed by the coiled coil assembly and binds vitamin D3 which is involved in bone and cartilage metabolism. An RGD sequence in the third TSP type-3 repeat mediates chondrocyte attachment via Integrins a5b1 or aVb3. COMP is upregulated in rheumatoid arthritis and osteoarthritis, hepatocellular carcinomas, chronic pancreatitis, and pancreatic carcinomas. Several mutations in COMP are associated with skeletal dysplasias.

Product Specifications for Simple Plex Control for Human COMP/Thrombospondin-5

Species	Human
Applications	Control, Simple Plex Automated Immunoassay
Source	N/A

Preparation & Storage

Shipping Conditions

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage

• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.

Background: COMP/Thrombospondin-5

Item	Value
Long Name	Cartilage Oligomeric Matrix Protein
Entrez Gene IDs	1311 (Human); 12845 (Mouse)
Alternate Names	COMP, EDM1, EPD1, MED, MEDMGC131819, MGC149768, PSACH, THBS5, TSP5, Thrombospondin-5, Thrombospondin5, cartilage oligomeric matrix protein, cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia1, multiple), cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia1, multiple), pseudoachondroplasia (epiphyseal dysplasia 1, multiple)

Product Documents for Simple Plex Control for Human COMP/Thrombospondin-5

Product Datasheets

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