VU 0357017 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4295
Positive allosteric modulator of M1 receptors
Key Product Details
Description
Positive allosteric modulator of M1 receptors
Product Description
VU 0357017 hydrochloride is a positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM). Displays no activity at M2-M5 at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.Product Specifications
Molecular Weight
369.89
Formula
C18H27N3O3.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester hydrochloride
CAS Number
1135242-13-5
PubChem ID
25010775
InChI Key
XKJQVUIXSBOCPP-UHFFFAOYSA-N
SMILES
CC1=CC=CC=C1C(NCCNC2CCN(C(OCC)=O)CC2)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.25 | 25 | |
| DMSO | 1.85 | 5 |
Preparing Stock Solutions
for VU 0357017 hydrochloride
The following data is based on the product molecular weight 369.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 10.81 mL | 54.07 mL | 108.14 mL |
| 1.25 mM | 2.16 mL | 10.81 mL | 21.63 mL |
| 2.5 mM | 1.08 mL | 5.41 mL | 10.81 mL |
| 12.5 mM | 0.22 mL | 1.08 mL | 2.16 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lebois Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system. ACS Chem.Neurosci.
- Bridges Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M1 PAM. Bioorg.Med.Chem.Lett. 2010 PMID: 20156687
Product Specific Notices for VU 0357017 hydrochloride
For research use only
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