Recombinant SARS-CoV-2 Spike S2 HR1 Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11879

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NBP3-11879
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Key Product Details

Source

E. coli

Conjugate

Unconjugated

View all Spike S2 HR1 Proteins and Enzymes »

Product Specifications

Description

A partial recombinant protein corresponding to SARS-CoV-2 Spike S2 Heptad Repeat 1.

Source: E.coli

Amino Acid Sequence: Gly910-Glu988

Purity

>95% pure by SDS-PAGE

Predicted Molecular Mass

8.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Partial Recombinant Protein

Formulation, Preparation and Storage

NBP3-11879
Formulation 0.2 uM filtered solution of PBS, pH 7.4
Concentration Please see the vial label for concentration. If unlisted please contact technical services.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C.

Background: Spike S2 HR1

The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. After binding of RBD in S1 subunit of S protein on the virion to the ACE2 receptor on the target cell, the heptad repeat 1 (HR1) and 2 (HR2) domains in its S2 subunit of S protein interact with each other to form a six-helix bundle (6-HB) fusion core, bringing viral and cellular membranes into close proximity for fusion and infection. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Alternate Names

COVID-19 Spike S2 HR1, S2 Protein Heptad Repeat 1, SARS-CoV-2 Spike S2 Heptad Repeat 1, Spike glycoprotein Subunit 2 HR1, Spike S2 4,3 hydrophobic repeat region 1

Gene Symbol

S

Additional Spike S2 HR1 Products

Product Documents for Recombinant SARS-CoV-2 Spike S2 HR1 Protein

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Recombinant SARS-CoV-2 Spike S2 HR1 Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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