Recombinant Human RGS17 His Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-72443

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NBP1-72443-0.5mg
NBP1-72443-100ug
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Key Product Details

Source

E. coli

Tag

His

Conjugate

Unconjugated

Applications

SDS-PAGE

View all RGS17 Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-210 of Human RGS17

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MRKRQQSQNE GTPAVSQAPG NQRPNNTCCF CWCCCCSCSC LTVRNEERGE NAGRPTHTTK MESIQVLEEC QNPTAEEVLS WSQNFDKMMK APAGRNLFRE FLRTEYSEEN LLFWLACEDL KKEQNKKVIE EKARMIYEDY ISILSPKEVS LDSRVREVIN RNLLDPNPHM YEDAQLQIYT LMHRDSFPRF LNSQIYKSFV ESTAGSSSES

Purity

>90%, by SDS-PAGE

Predicted Molecular Mass

26.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human RGS17 His Protein

SDS-PAGE: Recombinant Human RGS17 His Protein [NBP1-72443]

SDS-PAGE: Recombinant Human RGS17 His Protein [NBP1-72443]

SDS-Page: Recombinant Human RGS17 Protein [NBP1-72443] - 15% SDS-PAGE (3ug)

Formulation, Preparation and Storage

NBP1-72443
Formulation 20 mM Tris-HCl buffer (pH8.0), 10% glycerol, 0.1 M NaCl, 1 mM DTT
Preservative No Preservative
Concentration 1 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RGS17

RGS17, also known as regulator of G-protein signaling 17, attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. It plays an important role in termination of signalling by mu opioid receptors and development of tolerance to opioid analgesic drugs. Recombinant human RGS17 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Alternate Names

hRGS17, regulator of G-protein signaling 17, regulator of G-protein signalling 17, RGS-17, RGSZ2

Gene Symbol

RGS17

Additional RGS17 Products

Product Documents for Recombinant Human RGS17 His Protein

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human RGS17 His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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