Recombinant Mouse Limitin/IFN-zeta Fc Chimera Protein, CF

R&D Systems, part of Bio-Techne | Catalog # 597-LM

R&D Systems, part of Bio-Techne
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597-LM-010
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Key Product Details

  • R&D Systems NS0-derived Recombinant Mouse Limitin/IFN-zeta Fc Chimera Protein (597-LM)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Source

NS0

Accession #

BAA83749

Structure / Form

Disulfide-linked homodimer

Conjugate

Unconjugated

Applications

Bioactivity

View all Limitin/IFN-zeta Proteins and Enzymes »

Product Specifications

Source

Mouse myeloma cell line, NS0-derived mouse Limitin/IFN-zeta protein
Mouse Limitin
(Leu22 - Arg182)
Accession # BAA83749		 IEGRMD Human IgG1
(Pro100 - Lys330)
N-terminus C-terminus

Purity

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Endotoxin Level

<1.0 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Leu22

Predicted Molecular Mass

45.0 kDa (monomer)

SDS-PAGE

50-55 kDa, reducing conditions

Activity

Measured in an anti-viral assay using L-929 mouse fibroblast cells infected with encephalomyocarditis (EMC) virus. Vogel, S.N. et al. (1982) Infect. Immunol. 38:681.
The ED50 for this effect is 0.1-0.5 ng/mL.

Formulation, Preparation and Storage

597-LM
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution
Reconstitute at 100 μg/mL in sterile PBS.

Reconstitution Buffer Available:
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Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Limitin/IFN-zeta

Limitin is a secreted interferon (IFN)-like glycoprotein. It has antiviral activity and selectively inhibits B-lineage lymphoid-cell development both in vivo and in vitro, while having little effect on myelopoiesis or erythropoiesis. Mouse Limitin cDNA encodes a 182 amino acid (aa) residue precursor protein with an N-terminal 21 aa residue putative signal peptide. Limitin binds to the IFN-alpha / beta receptors and induces IFN regulatory factor-1. Mouse Limitin displays 32%, 26% and 30% amino acid identity with mouse IFN-alpha, mouse IFN-beta, and human IFN-omega, respectively.

References

  1. Oritani, K. et al. (2001) J. Mol. Med. 79:168.
  2. Oritani, K. et al. (2000) Nature Med. 6:659.

Long Name

Interferon zeta

Alternate Names

IFN-z, IFNzeta

Entrez Gene IDs

319146 (Mouse)

Gene Symbol

IFNZ

UniProt

BAA83749

Additional Limitin/IFN-zeta Products

Product Documents for Recombinant Mouse Limitin/IFN-zeta Fc Chimera Protein, CF

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Mouse Limitin/IFN-zeta Fc Chimera Protein, CF

For research use only

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