Recombinant Mouse IL-7 Protein

Name: Recombinant Mouse IL-7 Protein
Brand: R&D Systems
SKU: 407-ML
Rating: 4 (3 reviews)

R&D Systems, Inc. a Bio-Techne Brand

Catalog # 407-ML

Citations (100)

(3)

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Key Product Details

Source:	E. coli
Accession #:	Q544C8
Applications:	Bioactivity

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Product Specifications for Recombinant Mouse IL-7 Protein

Source	E. coli-derived mouse IL-7 protein Glu26-Ile154, with an N-terminal Met
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin level	<0.01 EU per 1 μg of the protein by the LAL method.
N-terminal sequence Analysis	Glu26
Predicted Molecular Mass	15 kDa
Activity	Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL). Yokota, T. et al. (1986) Proc. Natl. Acad. Sci. USA 83:5894. The ED₅₀ for this effect is 0.15-0.3 ng/mL.

Scientific Data Examples for Recombinant Mouse IL-7 Protein

	Recombinant Mouse IL-7 Protein Bioactivity Recombinant Mouse IL-7 (Catalog # 407-ML) stimulates cell proliferation of PHA-activated human peripheral blood lymphocytes. The ED₅₀ for this effect is 0.15-0.3 ng/mL.
	Recombinant Mouse IL-7 Protein SDS-PAGE 1 μg/lane of Recombinant Mouse IL-7 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 17 kDa.

Formulation, Preparation and Storage

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

407-ML

Carrier

Formulation	Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution	Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

407-ML/CF

Carrier Free

Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute 5 µg vials at 50 µg/mL in sterile PBS. Reconstitute 25 µg or larger vials at 100 µg/mL in sterile PBS.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Reconstitution Calculator

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Background: IL-7

IL-7 (interleukin-7) is a 25 kDa cytokine of the hemopoietin family that plays important roles in lymphocyte differentiation, proliferation, and survival (1-4). Mouse IL-7 cDNA encodes 154 amino acids (aa) that include a 25 aa signal peptide (4). Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 and 58-60% with human, equine, bovine, ovine, porcine, feline and canine IL-7. Human and mouse IL-7 exhibit cross-species activity (2, 3). IL-7 is produced by a wide variety of cells in primary and secondary lymphoid tissues, including stromal epithelial cells of the thymus, bone marrow, and intestines (1, 2, 5). Circulating IL-7 is limiting in healthy animals, but increases during lymphopenia (1, 6). IL-7 signals through a complex of the IL-7 Receptor alpha subunit (IL-7 R alpha, also known as CD127) with the common gamma chain ( gamma _c) (1). The gamma _c is also a subunit of the receptors for IL-2, -4, -9, -15, and -21 (1). IL-7 R alpha is expressed on double negative (CD4^-CD8^-) and CD4⁺ or CD8⁺ single positive naïve and memory T cells, but undergoes IL-7-mediated down‑regulation and shedding during antigen-driven T cell proliferation, and is absent on regulatory T cells (1, 2, 6-11). IL-7 contributes to the maintenance of all naïve and memory T cells, mainly by promoting expression of the anti-apoptotic protein Bcl-2 (9-11). It is required for optimal T cell-dendritic cell interaction (6). IL-7 is expressed early in B cell development prior to the appearance of surface IgM (1, 5, 9). In mouse, IL-7 activation of IL-7 R alpha is critical for both T cell and B cell lineage development, while in humans, it is required for T cell but not for B cell development (4, 9, 12, 13). However, IL-7 functions in both mouse and human pro-B cells to suppress premature Ig light chain recombination during proliferative growth (14, 15).

Item	Value
References	Sasson, S.C. et al. (2006) Curr. Drug Targets 7:1571. Barata, J.T. et al. (2006) Exp. Hematol. 34:1133. Goodwin, R.G. et al. (1990) Proc. Natl. Acad. Sci. USA 86:302. Namen, A.E. et al. (1988) Nature 333:571. Shalapour, S. et al. (2012) PLoS ONE 7: e31939. Saini, M. et al. (2009) Blood 113:5793. Park, J.H. et al. (2004) Immunity 21:289. Vranjkovic, A. et al. (2007) Int. Immunol. 19:1329. Sudo, T. et al. (1993) Proc. Natl. Acad. Sci. 90:9125. Seddon, B. et al. (2003) Nat. Immunol. 4:680. Schluns, K.S. et al. (2000) Nat. Immunol. 5:426. Peschon, J.J. et al. (1994) J. Exp. Med. 180:1955. Pribyl, J.A. and T.W. LeBien (1996) Proc. Natl. Acad. Sci. 93:10348. Johnson, K. et al. (2012) J. Immunol. 188:6084. Nodland, S.E. et al. (2011) Blood 118:2116.
Long Name	Interleukin 7
Entrez Gene IDs	3574 (Human); 16196 (Mouse); 25647 (Rat)
Alternate Names	IL-7, IL-7interleukin-7, IL7, Lymphopoietin-1, PBGF, interleukin 7

Citations for Recombinant Mouse IL-7 Protein (100)

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Citations are publications that use Bio-Techne products. Selected citations for Recombinant Mouse IL-7 Protein include:

Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Jeong et al. (2022), BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells Cell Death and Differentiation, 0(0).
PMID: 35473985
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Baran et al. (2022), Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia Nature Communications, 13(1):2801.
PMID: 35589701
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

EA Kuczynski et al. (2022), A preclinical model of peripheral T-cell lymphoma GATA3 reveals DNA damage response pathway vulnerability Embo Molecular Medicine, 0(0):e15816.
PMID: 35510955
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JH Badrani et al. (2022), RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R Nature Communications, 13(1):4435.
PMID: 35908044
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HS Lee et al. (2022), IL-23 plays a significant role in the augmentation of particulate matter-mediated allergic airway inflammation Journal of Cellular and Molecular Medicine, 0(0).
PMID: 35801505
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

P de Lucía F et al. (2021), Serum free culture for the expansion and study of type 2 innate lymphoid cells Scientific Reports, 11(1):12233.
PMID: 34112824
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CH Hsieh et al. (2021), An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment Theranostics, 11(14):7072-7091.
PMID: 34093872
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Lu et al. (2021), Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging Aging Cell, 0(0):e13353.
PMID: 33780118
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Srinivasan et al. (2021), Type 2 innate lymphoid cells from Id1 transgenic mice alleviate skin manifestations of graft-versus-host disease BMC immunology, 22(1):46.
PMID: 34256699
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

ME Kotas et al. (2021), CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone Mucosal Immunology, 0(0).
PMID: 34290377
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Hashimoto et al. (2021), Induction of alopecia areata in C3H/HeJ mice using cryopreserved lymphocytes Journal of dermatological science, 0(0).
PMID: 33994063
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TT Vo et al. (2021), Targeting eIF4F translation complex sensitizes B-ALL cells to tyrosine kinase inhibition Scientific Reports, 11(1):21689.
PMID: 34737376
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

P Prakhar et al. (2021), The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function JCI Insight, 6(21).
PMID: 34747370
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SP Fahl et al. (2021), The E protein-TCF1 axis controls &gamma&delta Tï¿½cell development and effector fate Cell Reports, 34(5):108716.
PMID: 33535043
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

S Steinmann et al. (2020), Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4+ T cells Sci Rep, 10(1):1071.
PMID: 31974518
OO Oyesola et al. (2020), The Prostaglandin D2 Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung J. Immunol., 204(4):1001-1011.
PMID: 31900341
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

V Peng et al. (2020), E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells J. Biol. Chem., 0(0).
PMID: 32817168
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Valletta et al. (2020), Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGF&beta1 as regulators of hematopoietic ageing Nat Commun, 11(1):4075.
PMID: 32796847
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

M Isidro-Her et al. (2020), Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis Sci Rep, 10(1):19189.
PMID: 33154497
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JM Inclan-Ric et al. (2020), Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition Nat. Immunol., 0(0).
PMID: 32807943
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Hong et al. (2020), Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System Biomedicines, 8(12).
PMID: 33317212
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Valletta et al. (2020), Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFbeta1 as regulators of hematopoietic ageing Nat Commun, 11(1):4075.
PMID: 32796847
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

V Peng et al. (2020), E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells J. Biol. Chem., 0(0).
PMID: 32817168
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JM Inclan-Ric et al. (2020), Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition Nat. Immunol., 0(0).
PMID: 32807943
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Goossens et al. (2019), ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms Haematologica, 0(0).
PMID: 30679322
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

DM Previte et al. (2019), Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells Cell Rep, 27(1):129-141.e4.
PMID: 30943396
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Konopacki et al. (2019), Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function Nat. Immunol., 20(2):232-242.
PMID: 30643266
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

B Maurer et al. (2019), High activation of STAT5A drives peripheral T-cell lymphoma and leukemia Haematologica, 0(0).
PMID: 31123029
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Ron-Harel et al. (2019), T Cell Activation Depends on Extracellular Alanine Cell Rep, 28(12):3011-3021.e4.
PMID: 31533027
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Mandal et al. (2019), CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis Nat. Immunol., 0(0).
PMID: 31477919
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

ELY Chen et al. (2019), RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors Nat. Immunol., 0(0).
PMID: 31636466
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

PT Mantani et al. (2019), ILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions BMC Immunol., 20(1):47.
PMID: 31823769
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Symowski et al. (2019), Th2 cell-derived IL-4/IL-13 promote ILC2 accumulation in the lung by ILC2-intrinsic STAT6 signaling in mice Eur. J. Immunol., 0(0).
PMID: 31144294
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Sasaki et al. (2019), Innate Lymphoid Cells in the Induction of Obesity Cell Rep, 28(1):202-217.e7.
PMID: 31269440
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Dai et al. (2018), Kbtbd2 inhibits the cytotoxic activity of immortalized NK cells through down-regulating mTOR signaling in a mouse hepatocellular carcinoma model Eur. J. Immunol., 0(0).
PMID: 29331106
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SSM Lee-Sayer et al. (2018), Hyaluronan-binding by CD44 reduces the memory potential of activated murine CD8 T cells Eur. J. Immunol., 0(0).
PMID: 29315518
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Yamaguchi et al. (2018), Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms Mucosal Immunol, 11(3):615-626.
PMID: 29346348
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

RR Ricardo-Go et al. (2018), Tissue signals imprint ILC2 identity with anticipatory function Nat. Immunol., 0(0).
PMID: 30201992
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SK Martin et al. (2018), mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis Sci Rep, 8(1):14501.
PMID: 30266921
Species: Mouse
Sample Types: Whole Cells
Applications: Stimulation

S Kojo et al. (2018), Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene Nat Commun, 9(1):3593.
PMID: 30185787
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Gérard et al. (2018), Microenvironment-derived ADAM28 prevents cancer dissemination Oncotarget, 9(98):37185-37199.
PMID: 30647853
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

KM Reeder et al. (2018), The common ?-chain cytokine IL-7 promotes immunopathogenesis during fungal asthma Mucosal Immunol, 11(5):1352-1362.
PMID: 29907867
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

A Seki et al. (2018), Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells J. Exp. Med., 0(0).
PMID: 29436394
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Ouchi et al. (2018), Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing Int. Immunol., 30(4):141-154.
PMID: 29617862
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

G Rodríguez- et al. (2017), Infection exposure promotes ETV6-RUNX1 precursor B cell leukemia via impaired H3K4 demethylases Cancer Res., 0(0).
PMID: 28630052
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Itoh-Nakad et al. (2017), A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors Cell Rep, 18(10):2401-2414.
PMID: 28273455
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MJ de Bruijn et al. (2017), Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling J. Immunol, 0(0).
PMID: 28275136
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HF Moffett et al. (2017), The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection Nat. Immunol., 0(0).
PMID: 28530712
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Shukla et al. (2017), Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1 Nat. Methods, 14(5):531-538.
PMID: 28394335
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Han et al. (2017), The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice J. Immunol., 0(0).
PMID: 28701507
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

P Tong et al. (2017), IgH isotype-specific B cell receptor expression influences B cell fate Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 28923960
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Wallrapp et al. (2017), The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation Nature, 549(7672):351-356.
PMID: 28902842
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Zhao et al. (2016), Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development J. Exp. Med, 213(9):1921-36.
PMID: 27526713
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sande O et al. (2016), Mannose-Capped Lipoarabinomannan from Mycobacterium tuberculosis Induces CD4+ T Cell Anergy via GRAIL. J Immunol, 196(2):691-702.
PMID: 26667170
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jakob von Moltke (2016), Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s J. Exp. Med, 0(0).
PMID: 28011865
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis Cell Death Dis, 7(11):e2479.
PMID: 27882948
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lubeck B et al. (2015), Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia. J Immunol, 195(1):31-5.
PMID: 26002977
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tamehiro N et al. (2015), Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint. PLoS ONE, 10(6):e0131047.
PMID: 26114424
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bando J et al. (2015), Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine. Nat Immunol, 16(2):153-60.
PMID: 25501629
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hao B et al. (2015), An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. J Exp Med, 212(5):809-24.
PMID: 25847946
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gerby B et al. (2015), SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells. PLoS Genet, 10(12):e1004768.
PMID: 25522233
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gandhapudi S et al. (2015), IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. J Immunol, 194(8):3820-8.
PMID: 25780034
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Smeets M et al. (2014), The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis. J Clin Invest, 124(8):3551-65.
PMID: 24960165
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nacionales D et al. (2014), Aged mice are unable to mount an effective myeloid response to sepsis. J Immunol, 192(2):612-22.
PMID: 24337739
Species: Mouse
Sample Types: Whole Cells

Cecil D et al. (2014), Elimination of IL-10-inducing T-helper epitopes from an IGFBP-2 vaccine ensures potent antitumor activity. Cancer Res, 74(10):2710-8.
PMID: 24778415
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cheadle E et al. (2014), Differential role of Th1 and Th2 cytokines in autotoxicity driven by CD19-specific second-generation chimeric antigen receptor T cells in a mouse model. J Immunol, 192(8):3654-65.
PMID: 24623129
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Liu C et al. (2014), Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation. J Immunol, 193(2):663-72.
PMID: 24920844
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wallington-Beddoe C et al. (2014), Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression. Cancer Res, 74(10):2803-15.
PMID: 24686171
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Coffey F et al. (2014), The TCR ligand-inducible expression of CD73 marks gammadelta lineage commitment and a metastable intermediate in effector specification. J Exp Med, 211(2):329-43.
PMID: 24493796
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Green M et al. (2014), Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma. Nat Commun, 5(0):3904.
PMID: 24887457
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Constantinides et al. (2014), A committed precursor to innate lymphoid cells. Nature, 508(7496):397-401.
PMID: 24509713
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Krutikov K et al. (2014), Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK. PLoS ONE, 9(2):e89649.
PMID: 24586935
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Berezhnoy et al. (2014), Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity. J Clin Invest, 124(1):188-97.
PMID: 24292708
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Marcais A et al. (2014), The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol, 15(8):749-57.
PMID: 24973821
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Badano M et al. (2013), B-cell lymphopoiesis is regulated by cathepsin L. PLoS ONE, 8(4):e61347.
PMID: 23585893
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lee et al. (2013), The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination. Mol Cell Biol, 33(9):1768-81.
PMID: 23438597
Bekiaris V et al. (2013), The inhibitory receptor BTLA controls gammadelta T cell homeostasis and inflammatory responses. Immunity, 39(6):1082-94.
PMID: 24315996
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Guo Z et al. (2013), A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. J Immunol, 190(7):3153-62.
PMID: 23427250
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nomachi et al. (2013), Moesin controls clathrin-mediated S1PR1 internalization in T cells. PLoS ONE, 8(12):e82590.
PMID: 24358210
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Olive V et al. (2013), A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife, 2(0):e00822.
PMID: 24137534
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Venigalla et al. (2013), PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development. EMBO J, 32(7):1008-22.
PMID: 23463102
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gupta S et al. (2012), Developmental heterogeneity in DNA packaging patterns influences T-cell activation and transmigration. PLoS ONE, 7(9):e43718.
PMID: 22957031
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Sneddon et al. (2012), Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature, 491(7426):765-8.
PMID: 23041930
Species: Mouse
Sample Types: In Vivo
Applications: Bioassay

Michel M et al. (2012), Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing gammadelta cells. Proc Natl Acad Sci U S A, 109(43):17549-54.
PMID: 23047700
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2012), Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 109(25):9971-6.
PMID: 22665806
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Johnson RM et al. (2012), Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract. J. Immunol., 188(4):1896-904.
PMID: 22238459
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Purushothaman D et al. (2012), Apoptotic programs are determined during lineage commitment of CD4+ T effectors: selective regulation of T effector-memory apoptosis by inducible nitric oxide synthase. J Immunol, 190(1):97-105.
PMID: 23225886
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bartemes KR et al. (2011), IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J. Immunol., 188(3):1503-13.
PMID: 22198948
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Kayamuro H et al. (2010), Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 84(24):12703-12.
PMID: 20881038
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Liu X et al. (2010), Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat. Med., 16(2):191-7.
PMID: 20062065
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chen X et al. (2009), Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway. J. Immunol., 183(10):6135-44.
PMID: 19841165
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Wu JY et al. (2008), Osteoblastic regulation of B lymphopoiesis is mediated by Gs alpha-dependent signaling pathways. Proc. Natl. Acad. Sci. U.S.A., 105(44):16976-81.
PMID: 18957542
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Vang KB et al. (2008), IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development. J. Immunol., 181(5):3285-90.
PMID: 18714000
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhu J et al. (2007), Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood, 109(9):3706-12.
PMID: 17227831
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bekiaris V et al. (2007), Role of CD30 in B/T segregation in the spleen. J. Immunol., 179(11):7535-43.
PMID: 18025198
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zheng SG et al. (2007), IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol., 178(4):2018-27.
PMID: 17277105
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Letterio J et al. (2006), Transforming growth factor-beta1 sensitivity is altered in Abl-Myc- and Raf-Myc-induced mouse pre-B-cell tumors. Stem Cells, 24(12):2611-7.
PMID: 16945999
Lai L et al. (2005), A recombinant single-chain IL-7/HGFbeta hybrid cytokine induces juxtacrine interactions of the IL-7 and HGF (c-Met) receptors and stimulates the proliferation of CFU-S12, CLPs, and pre-pro-B cells. Blood, 107(5):1776-84.
PMID: 16304052
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Endharti AT et al. (2005), Galectin-1 supports survival of naive T cells without promoting cell proliferation. Eur. J. Immunol., 35(1):86-97.
PMID: 15593120
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Alpdogan O et al. (2001), Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood, 98(7):2256-65.
PMID: 11568014

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Recombinant Mouse IL-7 Protein

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