Recombinant Mouse IL-2 Protein

Name: Recombinant Mouse IL-2 Protein
Brand: R&D Systems
SKU: 402-ML
Rating: 5 (9 reviews)

R&D Systems, Inc. a Bio-Techne Brand

Catalog # 402-ML

Citations (232)

(9)

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Key Product Details

Source:	E. coli
Accession #:	P04351
Applications:	Bioactivity

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Product Specifications for Recombinant Mouse IL-2 Protein

Source	E. coli-derived mouse IL-2 protein Ala21-Gln169, with and without an N-terminal Met
Purity	>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin level	<0.10 EU per 1 μg of the protein by the LAL method.
N-terminal sequence Analysis	Ala21 & Met
Predicted Molecular Mass	17.2 kDa
Activity	Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. Gearing, A.J.H. and C.B. Bird (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 295. The ED₅₀ for this effect is 0.1-0.4 ng/mL.

Scientific Data Examples for Recombinant Mouse IL-2 Protein

	Recombinant Mouse IL-2 Protein Bioactivity Recombinant Mouse IL-2 (Catalog # 402-ML) stimulates cell proliferation of the CTLL-2 mouse cytotoxic T cell line. The ED₅₀ for this effect is 0.1-0.4 ng/mL.
	Recombinant Mouse IL-2 Protein SDS-PAGE 1 μg/lane of Recombinant Mouse IL-2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a band(s) at 19 kDa.

Formulation, Preparation and Storage

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

402-ML

Carrier

Formulation	Lyophilized from a 0.2 μm filtered solution in Sodium Citrate and Tween®-80 with BSA as a carrier protein.
Reconstitution	Reconstitute at 100-200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

402-ML/CF

Carrier Free

Formulation	Lyophilized from a 0.2 μm filtered solution in Sodium Citrate and Tween®-80.
Reconstitution	Reconstitute at 100-200 μg/mL in sterile deionized water.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

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Background: IL-2

Interleukin‑2 (IL‑2) is a O‑glycosylated four alpha ‑helix bundle cytokine that has potent stimulatory activity for antigen‑activated T cells. It is expressed by CD4⁺ and CD8⁺ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils (1‑3). Mature mouse IL‑2 shares 56% and 73% aa sequence identity with human and rat IL‑2, respectively. It shows strain‑specific heterogeneity in an N‑terminal region that contains a poly‑glutamine stretch (4). Mouse and human IL‑2 exhibit cross‑species activity (5). The receptor for IL‑2 consists of three subunits that are present on the cell surface in varying preformed complexes (6‑8). The 55 kDa IL‑2 R alpha is specific for IL‑2 and binds with low affinity. The 75 kDa IL‑2 R beta, which is also a component of the IL‑15 receptor, binds IL‑2 with intermediate affinity. The 64 kDa common gamma chain gamma c/IL-2 R gamma, which is shared with the receptors for IL‑4, ‑7, ‑9, ‑15, and ‑21, does not independently interact with IL‑2. Upon ligand binding, signal transduction is performed by both IL‑2 R beta and gamma c. IL‑2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to proliferate and induces IL‑2 and IL‑2 R alpha synthesis (1, 2). It contributes to T cell homeostasis by promoting the Fas‑induced death of naïve CD4⁺ T cells but not activated CD4⁺ memory lymphocytes (9). IL‑2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells (10‑12). Thus, IL‑2 may be a key cytokine in the natural suppression of autoimmunity (13, 14).

Item	Value
References	Ma, A. et al. (2006) Annu. Rev. Immunol. 24:657. Gaffen, S.L. and K.D. Liu (2004) Cytokine 28:109. Kashima, N. et al. (1985) Nature 313:402. Matesanz, F. et al. (1993) Immunogenetics 38:300. Mosmann, T.R. et al. (1987) J. Immunol. 138:1813. Liparoto, S.F. et al. (2002) Biochemistry 41:2543. Wang, X. et al. (2005) Science 310:1159. Bodnar, A. et al. (2008) Immunol. Lett. 116:117. Jaleco, S. et al. (2003) J. Immunol. 171:61. Malek, T.R. (2003) J. Leukoc. Biol. 74:961. Laurence, A. et al. (2007) Immunity 26:371. Kryczek, I. et al. (2007) J. Immunol. 178:6730. Afzali, B. et al. (2007) Clin. Exp. Immunol. 148:32. Fehervari, Z. et al. (2006) Trends Immunol. 27:109.
Long Name	Interleukin 2
Entrez Gene IDs	3558 (Human); 16183 (Mouse); 116562 (Rat); 396868 (Porcine); 280822 (Bovine); 403989 (Canine); 100034204 (Equine); 751114 (Feline); 100302458 (Rabbit)
Alternate Names	Aldesleukin, IL-2, IL-2lymphokine, IL2, Proleukin, T cell growth factor, T-cell growth factor, TCGF, interleukin 2, interleukin-2, involved in regulation of T-cell clonal expansion

Citations for Recombinant Mouse IL-2 Protein (232)

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Citations are publications that use Bio-Techne products. Selected citations for Recombinant Mouse IL-2 Protein include:

Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Peng et al. (2022), Development of a Spontaneous HPV16 E6/E7-Expressing Head and Neck Squamous Cell Carcinoma in HLA-A2 Transgenic Mice MBio, 0(0):e0325221.
PMID: 35089069
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Jorapur et al. (2022), EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22 PloS Pathogens, 18(1):e1010200.
PMID: 35025968
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

PL Vu et al. (2022), A Mutated Prostatic Acid Phosphatase (PAP) Peptide-Based Vaccine Induces PAP-Specific CD8+ T Cells with Ex Vivo Cytotoxic Capacities in HHDII/DR1 Transgenic Mice Cancers, 14(8).
PMID: 35454873
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

B Wu et al. (2022), RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity Nature Communications, 13(1):2155.
PMID: 35444206
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

LEA Damasceno et al. (2022), STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program Cell Reports, 39(8):110838.
PMID: 35613599
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

JN Chi et al. (2022), MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear export and Foxp3 downregulation Theranostics, 12(13):5744-5760.
PMID: 35966593
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JH Badrani et al. (2022), RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R Nature Communications, 13(1):4435.
PMID: 35908044
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

E Shelkey et al. (2022), Immuno-reactive cancer organoid model to assess effects of the microbiome on cancer immunotherapy Scientific Reports, 12(1):9983.
PMID: 35705580
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HS Lee et al. (2022), IL-23 plays a significant role in the augmentation of particulate matter-mediated allergic airway inflammation Journal of Cellular and Molecular Medicine, 0(0).
PMID: 35801505
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Peng et al. (2022), Identification of human MHC-I HPV18 E6/E7-specific CD8?+?T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice Journal of Biomedical Science, 29(1):80.
PMID: 36224625
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CH Hsieh et al. (2021), An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment Theranostics, 11(14):7072-7091.
PMID: 34093872
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Lu et al. (2021), Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging Aging Cell, 0(0):e13353.
PMID: 33780118
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Guan et al. (2021), Bruton's tyrosine kinase regulates gut immune homeostasis through attenuating Th1 response Cell Death Disease, 2021;12(5):431.
PMID: 33931590
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SH Shin et al. (2021), Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells International Journal of Molecular Sciences, 22(5).
PMID: 33800208
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Zhou et al. (2021), m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity Science Advances, 7(25).
PMID: 34134995
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Katsuyama et al. (2021), Splicing factor SRSF1 is indispensable for regulatory Tï¿½cell homeostasis and function Cell Reports, 36(1):109339.
PMID: 34233194
H Zhang et al. (2021), Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development Cell Reports, 35(6):109096.
PMID: 33979619
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Sheppard et al. (2021), Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function Cell Reports, 35(9):109210.
PMID: 34077737
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

ME Kotas et al. (2021), CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone Mucosal Immunology, 0(0).
PMID: 34290377
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JL Sun et al. (2021), Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages Journal of Translational Medicine, 19(1):347.
PMID: 34389031
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HZ Guo et al. (2021), Leukemic progenitor cells enable immunosuppression and post-chemotherapy relapse via IL-36-inflammatory monocyte axis Science Advances, 7(41):eabg4167.
PMID: 34623912
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Fan et al. (2021), The phenotypic and functional study of tissue B cells in respiratory system provided important information for diseases and development of vaccines Journal of Cellular and Molecular Medicine, 0(0).
PMID: 33481318
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Yu et al. (2021), Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination Nature Medicine, 0(0).
PMID: 33398162
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry

CG Burke et al. (2021), DNA Methylation Patterns in CD 4 + T Cells of Naï¿½ve and Influenza A Virus-Infected Mice Developmentally Exposed to an Aryl Hydrocarbon Receptor Ligand Environmental health perspectives, 129(1):17007.
PMID: 33449811
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Fleury et al. (2021), Partial STAT5 signaling is sufficient for CD4+ T cell priming but not memory formation Cytokine, 150(0):155770.
PMID: 34839177
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JL Liu et al. (2021), Circadian Clock Disruption Suppresses PDL1+ Intraepithelial B-cells in Experimental Colitis and Colitis Associated Colorectal Cancer Cellular and Molecular Gastroenterology and Hepatology, 0(0).
PMID: 33652118
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Wang et al. (2021), miR-20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis Journal of Translational Medicine, 19(1):223.
PMID: 34039371
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

I Safina et al. (2021), Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells PLoS ONE, 16(8):e0241882.
PMID: 34460818
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

S Steinmann et al. (2020), Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4+ T cells Sci Rep, 10(1):1071.
PMID: 31974518
Species: Mouse
Sample Types: Whole Cell
Applications: Bioassay

CW Keller et al. (2020), CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation Autophagy, 0(0):1-15.
PMID: 32401602
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

X Guo et al. (2020), Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth Nat Commun, 11(1):2177.
PMID: 32358581
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

H Baek et al. (2020), Bee Venom Phospholipase A2 Induces Regulatory T Cell Populations by Suppressing Apoptotic Signaling Pathway Toxins (Basel), 12(3).
PMID: 32235689
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

CA Bessell et al. (2020), Commensal bacteria stimulate antitumor responses via T cell cross-reactivity JCI Insight, 5(8).
PMID: 32324171
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

LA Sacramento et al. (2020), TLR4 abrogates the Th1 immune response through IRF1 and IFN-&beta to prevent immunopathology during L. infantum infection PLoS Pathog., 16(3):e1008435.
PMID: 32210480
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Simula et al. (2020), JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction Cell Death Differ., 0(0).
PMID: 32346136
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MND Svensson et al. (2020), Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal Sci Adv, 6(26):eaba4353.
PMID: 32637608
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Seo et al. (2020), Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity Nat Commun, 11(1):1562.
PMID: 32218434
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

F do Valle D et al. (2020), Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis JCI Insight, 5(3).
PMID: 32051345
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

KM Au et al. (2020), Trispecific natural killer cell nanoengagers for targeted chemoimmunotherapy Sci Adv, 6(27):eaba8564.
PMID: 32923587
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

V Peng et al. (2020), E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells J. Biol. Chem., 0(0).
PMID: 32817168
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

A Villegas-M et al. (2020), Exhausted CD4+ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression J. Immunol., 0(0).
PMID: 32817333
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JH Kang et al. (2020), Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division Nat Commun, 11(1):4983.
PMID: 33020492
Species: Mouse
Sample Types: In Vivo
Applications: Bioassay

EJ Bassin et al. (2020), TRI microparticles prevent inflammatory arthritis in a collagen-induced arthritis model PLoS ONE, 15(9):e0239396.
PMID: 32966314
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Pan et al. (2020), PPP2R2D suppresses interleukin-2 production and regulatory T cell function JCI Insight, 5(19).
PMID: 32897879
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Tur et al. (2020), Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity Cell Rep, 32(8):108079.
PMID: 32846136
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JM Inclan-Ric et al. (2020), Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition Nat. Immunol., 0(0).
PMID: 32807943
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Wagner et al. (2020), Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s Cell Rep, 30(8):2743-2757.e5.
PMID: 32101749
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

GM Wiedemann et al. (2020), Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells Cell Reports, 33(11):108498.
PMID: 33326784
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Ochiai et al. (2020), Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4 Cell Reports, 33(12):108517.
PMID: 33357426
Species: Transgenic Mouse
Sample Types: Spheroid
Applications: Bioassay

AE Engler et al. (2020), Airway-Associated Macrophages in Homeostasis and Repair Cell Reports, 33(13):108553.
PMID: 33378665
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Yan et al. (2020), T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Cell Rep, 31(13):107820.
PMID: 32610123
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

JL Galeano Ni et al. (2020), The Lifeact-EGFP mouse is a translationally controlled fluorescent reporter of T cell activation J. Cell. Sci., 0(0).
PMID: 32041902
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Koga et al. (2020), Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation Cell Mol Immunol, 0(0).
PMID: 33037399
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Liu et al. (2020), Eosinophils improve cardiac function after myocardial infarction Nature Communications, 11(1):6396.
PMID: 33328477
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Tur et al. (2020), Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity Cell Rep, 32(8):108079.
PMID: 32846136
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Villegas-M et al. (2020), Exhausted CD4+ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression J. Immunol., 0(0).
PMID: 32817333
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

V Peng et al. (2020), E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells J. Biol. Chem., 0(0).
PMID: 32817168
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JM Inclan-Ric et al. (2020), Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition Nat. Immunol., 0(0).
PMID: 32807943
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Li et al. (2020), T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice JCI Insight, 5(11).
PMID: 32493841
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Ott et al. (2019), Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes a CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity J Neuroinflammation, 16(1):49.
PMID: 30808363
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Feng et al. (2019), Pharmacological inhibition of ?-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells Sci Adv, 5(5):eaau5240.
PMID: 31086813
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MH McGuire et al. (2019), Pan-cancer genomic analysis links 3'UTR DNA methylation with increased gene expression in T cells EBioMedicine, 0(0).
PMID: 31056473
Species: Mouse
Sample Types: cell culture
Applications: cell culture media

MB Jones et al. (2019), CD45Rb-low effector T cells require IL-4 to induce IL-10 in FoxP3 Tregs and to protect mice from inflammation PLoS ONE, 14(5):e0216893.
PMID: 31120919
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Abdullah et al. (2019), Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis PLoS ONE, 14(4):e0215981.
PMID: 31026283
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Morales De et al. (2019), Costimulation Induces CD4ï¿½T Cell Antitumor Immunity via an Innate-like Mechanism Cell Rep, 27(5):1434-1445.e3.
PMID: 31042471
Species: Mouse
Sample Types: Whole Cells
Applications: Stimulation

H Dong et al. (2019), The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc Nat. Immunol., 0(0).
PMID: 31086333
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JQ Yang et al. (2019), Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation J. Leukoc. Biol., 0(0).
PMID: 31260596
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Tackett et al. (2019), Prolonged exposure to simulated microgravity diminishes dendritic cell immunogenicity Sci Rep, 9(1):13825.
PMID: 31554863
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

LP Araujo et al. (2019), The Sympathetic Nervous System Mitigates CNS Autoimmunity via Î²2-Adrenergic Receptor Signaling in Immune Cells Cell Rep, 28(12):3120-3130.e5.
PMID: 31533035
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Qu et al. (2019), TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development J Neuroinflammation, 16(1):183.
PMID: 31561751
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JH Bradley et al. (2019), Simulated microgravity-mediated reversion of murine lymphoma immune evasion Sci Rep, 9(1):14623.
PMID: 31602007
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

A Rose et al. (2019), IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis Cells, 8(10).
PMID: 31614462
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Mu et al. (2019), CD226 deficiency on regulatory T cells aggravates renal fibrosis via up-regulation of Th2 cytokines through miR-340 J. Leukoc. Biol., 0(0).
PMID: 31802539
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

P Obeidy et al. (2019), Partial loss of actin nucleator Actin Related Protein 2/3 activity triggers blebbing in primary T lymphocytes Immunol. Cell Biol., 0(0).
PMID: 31698518
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Y Zhu et al. (2019), Amplification of tumor antigen presentation by NLGplatin to improve chemoimmunotherapy Int J Pharm, 0(0):118736.
PMID: 31756442
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Racioppi et al. (2019), CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer Nat Commun, 10(1):2450.
PMID: 31164648
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Radulovic et al. (2019), NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death J. Immunol., 0(0).
PMID: 31152078
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Sasaki et al. (2019), Innate Lymphoid Cells in the Induction of Obesity Cell Rep, 28(1):202-217.e7.
PMID: 31269440
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SK Varanasi et al. (2018), Hexokinase II may be dispensable for CD4 T cell responses against a virus infection PLoS ONE, 13(1):e0191533.
PMID: 29352298
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Dai et al. (2018), Kbtbd2 inhibits the cytotoxic activity of immortalized NK cells through down-regulating mTOR signaling in a mouse hepatocellular carcinoma model Eur. J. Immunol., 0(0).
PMID: 29331106
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HH Abdul-Raza et al. (2018), Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency Sci Rep, 8(1):8214.
PMID: 29844458
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Yamaguchi et al. (2018), Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms Mucosal Immunol, 11(3):615-626.
PMID: 29346348
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Zamarin et al. (2018), PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy J. Clin. Invest., 0(0).
PMID: 29504948
Species: Mouse
Sample Types: Whole Cells

R Yang et al. (2018), Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway Stem Cell Res Ther, 9(1):62.
PMID: 29523215
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Teruya et al. (2018), Egr2-independent, Klf1-mediated induction of PD-L1 in CD4+ T cells Sci Rep, 8(1):7021.
PMID: 29728568
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Cosenza et al. (2018), Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis Theranostics, 8(5):1399-1410.
PMID: 29507629
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Lei et al. (2018), Crucial role of OX40/OX40L signaling in a murine model of asthma Mol Med Rep, 0(0).
PMID: 29344664
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Y Omata et al. (2018), Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice Cell Rep, 24(1):169-180.
PMID: 29972778
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HA Ting et al. (2018), Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection Mucosal Immunol, 0(0).
PMID: 30038214
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Zhang et al. (2018), OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms Cell Rep, 24(3):607-618.
PMID: 30021159
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

V Jelen?i? et al. (2018), NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development Nat. Immunol., 0(0).
PMID: 30224819
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Wu et al. (2018), Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function J Immunol Res, 2018(0):1605341.
PMID: 30159338
Species: Mouse
Sample Types: Transfected Whole Cells
Applications: Bioassay

S Liu et al. (2018), Taste Receptor T1R1/T1R3 Promotes the Tumoricidal Activity of Hepatic CD49a+CD49b- Natural Killer Cells Eur. J. Immunol., 0(0).
PMID: 30259960
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CD Geary et al. (2018), Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection Cell Rep, 24(8):1949-1957.e6.
PMID: 30134157
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

S Kojo et al. (2018), Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene Nat Commun, 9(1):3593.
PMID: 30185787
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SK Varanasi et al. (2018), Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions Mucosal Immunol, 0(0).
PMID: 30087443
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Gilleron et al. (2018), Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance Cell Rep, 25(12):3329-3341.e5.
PMID: 30566860
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Simula et al. (2018), Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming Cell Rep, 25(11):3059-3073.e10.
PMID: 30540939
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AM Falcão et al. (2018), Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis Nat. Med., 0(0).
PMID: 30420755
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Chennamadh et al. (2018), Dual Modifications of ?-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity Cell Chem Biol, 0(0).
PMID: 29576533
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

H Zhong et al. (2018), TGF-?-Induced CD8CD103Regulatory T Cells Show Potent Therapeutic Effect on Chronic Graft-versus-Host Disease Lupus by Suppressing B Cells Front Immunol, 9(0):35.
PMID: 29441062
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CT Petersen et al. (2018), Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3K? inhibitors and VIP antagonists Blood Adv, 2(3):210-223.
PMID: 29386194
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

A Seki et al. (2018), Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells J. Exp. Med., 0(0).
PMID: 29436394
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Ouchi et al. (2018), Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing Int. Immunol., 30(4):141-154.
PMID: 29617862
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Herndler-B et al. (2018), KLRG1+Effector CD8+T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity Immunity, 0(0).
PMID: 29625895
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Fu et al. (2017), Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression Mediators Inflamm., 2017(0):5706152.
PMID: 29056830
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

X Qu et al. (2017), MiR-384 Regulates the Th17/Treg Ratio during Experimental Autoimmune Encephalomyelitis Pathogenesis Front Cell Neurosci, 11(0):88.
PMID: 28400721
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Z You et al. (2017), BJ-2266 ameliorates experimental autoimmune encephalomyelitis through down-regulation of the JAK/STAT signaling pathway Eur. J. Immunol., 0(0).
PMID: 28681958
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

G Nagalingam et al. (2017), Modulation of Roquin Function in Myeloid Cells Reduces Mycobacterium tuberculosis-Induced Inflammation J. Immunol., 0(0).
PMID: 28747346
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SY Qu et al. (2017), Transcription factor RBP-J-mediated signaling regulates Basophil's immunoregulatory function in mouse asthma model Immunology, 0(0).
PMID: 28493549
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R Singh et al. (2017), Egr2 and 3 Inhibit T-bet-Mediated IFN-? Production in T Cells J. Immunol., 0(0).
PMID: 28455436
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

LT McDonald et al. (2017), Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis PLoS ONE, 12(7):e0180724.
PMID: 28700752
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HP Thu Le et al. (2017), The frequency of Th17ï¿½cells in the small intestine exhibits a day-night variation dependent on circadian clock activity Biochem. Biophys. Res. Commun., 0(0).
PMID: 28619514
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Oh-Oka et al. (2017), Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor Cell Mol Gastroenterol Hepatol, 4(1):135-151.
PMID: 28593185
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Tian et al. (2017), Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming Nature, 0(0).
PMID: 28371798
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Lin et al. (2017), NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis Sci Rep, 7(1):12895.
PMID: 29038541
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Hosokawa et al. (2017), Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function J. Immunol., 0(0).
PMID: 28768723
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Pan et al. (2017), The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells Parasit Vectors, 10(1):348.
PMID: 28732522
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Han et al. (2017), The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice J. Immunol., 0(0).
PMID: 28701507
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IA Mufazalov et al. (2017), Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells Eur. J. Immunol., 0(0).
PMID: 28598502
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Plaza-Sirv et al. (2017), c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity Cell Rep, 18(1):22-Dec.
PMID: 28052242
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SK Varanasi et al. (2017), Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects J. Immunol., 0(0).
PMID: 28768727
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

VS Pelly et al. (2017), Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths J. Exp. Med., 214(6):1809-1826.
PMID: 28507062
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

E Oh et al. (2017), Optimized biodegradable polymeric reservoir-mediated local and sustained co-delivery of dendritic cells and oncolytic adenovirus co-expressing IL-12 and GM-CSF for cancer immunotherapy J Control Release, 0(0).
PMID: 28336378
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H Yang et al. (2017), Viral RNA-Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance J. Immunol., 0(0).
PMID: 28550197
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HF Moffett et al. (2017), The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection Nat. Immunol., 0(0).
PMID: 28530712
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

DC Nascimento et al. (2017), IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population Nat Commun, 8(0):14919.
PMID: 28374774
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation Sci Rep, 6(0):38387.
PMID: 27929069
M Rita I Young (2016), Premalignant Oral Lesion Cells Elicit Increased Cytokine Production and Activation of T-cells Anticancer Res., 36(7):3261-70.
PMID: 27354582
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Shweta Pasi (2016), Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response J Biol Chem, 291(23):12358-69.
PMID: 27022030
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nimi Marcel (2016), Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells Elife, 5(0).
PMID: 27267497
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Szklany et al. (2016), Superior Cervical Ganglia Neurons Induce Foxp3+ Regulatory T Cells via Calcitonin Gene-Related Peptide PLoS ONE, 11(3):e0152443.
PMID: 27022966
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Premalignant Oral Lesion Cells Elicit Increased Cytokine Production and Activation of T-cells Anticancer Res., 36(7):3261-70.
PMID: 27354582
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Cancer stem cell-secreted macrophage migration inhibitory factor stimulates myeloid derived suppressor cell function and facilitates glioblastoma immune evasion Stem Cells, 0(0).
PMID: 27145382
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), BPTF Depletion Enhances T Cell Mediated Antitumor Immunity Cancer Res, 0(0).
PMID: 27651309
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

John A Hammer (2016), Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse J. Cell Biol., 215(3):383-399.
PMID: 27799367
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Torres et al. (2016), IL-12p40/IL-10 Producing preCD8?/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection PLoS Pathog, 12(4):e1005561.
PMID: 27074026
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

BW Li et al. (2016), T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice Eur J Immunol, 0(0).
PMID: 27062360
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

David A Hildeman (2016), Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCR? Repertoire J. Immunol., 0(0).
PMID: 27852740
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Shibuya M et al. (2015), A new T-cell activation mode for suboptimal doses of antigen under the full activation of T cells with different specificity. Eur J Immunol, 45(6):1643-53.
PMID: 25789709
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bergot A et al. (2015), TCR sequences and tissue distribution discriminate the subsets of naive and activated/memory Treg cells in mice. Eur J Immunol, 45(5):1524-34.
PMID: 25726757
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Raich-Regue D et al. (2015), mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo. J Immunol, 194(10):4767-76.
PMID: 25840913
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Klimatcheva E et al. (2015), CXCL13 antibody for the treatment of autoimmune disorders. BMC Immunol, 16(0):6.
PMID: 25879435
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Okamura T et al. (2015), TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses. Nat Commun, 6(0):6329.
PMID: 25695838
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Quan S et al. (2015), Impaired dendritic cell function in a spontaneous autoimmune polyneuropathy. J Immunol, 194(9):4175-84.
PMID: 25825437
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Rutz S et al. (2015), Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature, 518(7539):417-21.
PMID: 25470037
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Karsten C et al. (2015), Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse. J Immunol, 194(4):1841-55.
PMID: 25589074
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Beck B et al. (2015), Dynamics of Circulating gammadelta T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma. PLoS ONE, 10(5):e0122387.
PMID: 25955158
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhang Y et al. (2015), Anti-CD40-induced inflammatory E-cadherin+ dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma. J Exp Clin Cancer Res, 34(0):11.
PMID: 25651850
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhu C et al. (2015), An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nat Commun, 6(0):6072.
PMID: 25614966
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Solt L et al. (2015), ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes. Endocrinology, 156(3):869-81.
PMID: 25560829
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ueda H et al. (2015), Distinct Roles of Cytoskeletal Components in Immunological Synapse Formation and Directed Secretion. J Immunol, 195(9):4117-25.
PMID: 26392461
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lubeck B et al. (2015), Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia. J Immunol, 195(1):31-5.
PMID: 26002977
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Benkhoucha M et al. (2014), Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells. J Immunol, 193(6):2743-52.
PMID: 25114100
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhu E et al. (2014), miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORgammat and STAT3. J Immunol, 192(12):5599-609.
PMID: 24842756
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Beaulieu A et al. (2014), The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection. Nat Immunol, 15(6):546-53.
PMID: 24747678
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Rothchild A et al. (2014), iNKT cell production of GM-CSF controls Mycobacterium tuberculosis. PLoS Pathog, 10(1):e1003805.
PMID: 24391492
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ling W et al. (2014), Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res, 74(5):1576-87.
PMID: 24452999
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Liou Y et al. (2014), Adipocyte IL-15 regulates local and systemic NK cell development. J Immunol, 193(4):1747-58.
PMID: 25009203
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hagemann U et al. (2014), Fully human antagonistic antibodies against CCR4 potently inhibit cell signaling and chemotaxis. PLoS ONE, 9(7):e103776.
PMID: 25080123
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chen C et al. (2014), Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression. EMBO Mol Med, 6(3):322-34.
PMID: 24401839
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ashino S et al. (2014), Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses. J Allergy Clin Immunol, 133(4):1162-74.
PMID: 24365136
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bhela S et al. (2014), Critical role of microRNA-155 in herpes simplex encephalitis. J Immunol, 192(6):2734-43.
PMID: 24516198
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Liu C et al. (2014), Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation. J Immunol, 193(2):663-72.
PMID: 24920844
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Liu F et al. (2014), Timed action of IL-27 protects from immunopathology while preserving defense in influenza. PLoS Pathog, 10(5):e1004110.
PMID: 24809349
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhong W et al. (2014), Basophils as a primary inducer of the T helper type 2 immunity in ovalbumin-induced allergic airway inflammation. Immunology, 142(2):202-15.
PMID: 24383680
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kim E et al. (2014), Embryonic stem cell-derived haematopoietic progenitor cells down-regulate the CD3 xi chain on T cells, abrogating alloreactive T cells. Immunology, 142(3):421-30.
PMID: 24527810
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Rojo J et al. (2014), Characteristics of TCR/CD3 complex CD3{varepsilon} chains of regulatory CD4+ T (Treg) lymphocytes: role in Treg differentiation in vitro and impact on Treg in vivo. J Leukoc Biol, 95(3):441-50.
PMID: 24212096
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Minagawa K et al. (2014), Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL. J Immunol, 192(4):1512-24.
PMID: 24415781
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhang Y et al. (2014), Galectin-9 induced myeloid suppressor cells expand regulatory T cells in an IL-10-dependent manner in CVB3-induced acute myocarditis. Int J Mol Sci, 15(3):3356-72.
PMID: 24573249
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Neumann C et al. (2014), Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med, 211(9):1807-19.
PMID: 25073792
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

VanGundy et al. (2014), Continuous retinoic acid induces the differentiation of mature regulatory monocytes but fails to induce regulatory dendritic cells. BMC Immunol, 15(0):8.
PMID: 24548459
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Komatsu N et al. (2014), Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med, 20(1):62-8.
PMID: 24362934
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Aziz M et al. (2014), Upregulation of GRAIL is associated with impaired CD4 T cell proliferation in sepsis. J Immunol, 192(5):2305-14.
PMID: 24477910
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yang C et al. (2014), Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. J Immunol, 192(4):1547-57.
PMID: 24403530
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bauer et al. (2014), Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction. J Clin Invest, 124(6):2425-40.
PMID: 24812664
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jiang E et al. (2014), Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue. Arterioscler Thromb Vasc Biol, 34(1):34-43.
PMID: 24158516
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Engler D et al. (2014), Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10. Proc Natl Acad Sci U S A, 111(32):11810-5.
PMID: 25074917
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zarling S et al. (2013), The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria. J Immunol, 190(10):5128-41.
PMID: 23589611
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dudda J et al. (2013), MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity, 38(4):742-53.
PMID: 23601686
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kidani et al. (2013), Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol, 14(5):489-99.
PMID: 23563690
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dong B et al. (2013), Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization. PLoS ONE, 8(11):e80500.
PMID: 24260404
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Carey et al. (2013), Nfil3 is a glucocorticoid-regulated gene required for glucocorticoid-induced apoptosis in male murine T cells. Endocrinology, 154(4):1540-52.
PMID: 23425966
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Golden-Mason L et al. (2013), Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol, 87(9):4835-45.
PMID: 23408620
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jachetti et al. (2013), Prostate cancer stem cells are targets of both innate and adaptive immunity and elicit tumor-specific immune responses. Oncoimmunology, 2(5):e24520.
PMID: 23762811
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hoffmann U et al. (2013), Regulation and migratory role of P-selectin ligands during intestinal inflammation. PLoS ONE, 8(4):e62055.
PMID: 23630623
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nomachi et al. (2013), Moesin controls clathrin-mediated S1PR1 internalization in T cells. PLoS ONE, 8(12):e82590.
PMID: 24358210
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Purushothaman D et al. (2012), Apoptotic programs are determined during lineage commitment of CD4+ T effectors: selective regulation of T effector-memory apoptosis by inducible nitric oxide synthase. J Immunol, 190(1):97-105.
PMID: 23225886
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yoshida S et al. (2012), Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair. J. Immunol., 188(8):3972-9.
PMID: 22403443
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Radulovic K et al. (2012), CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential. J. Immunol., 188(4):2001-13.
PMID: 22250092
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhao E et al. (2012), Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer. Oncoimmunology, 1(2):152-161.
PMID: 22720236
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Arias et al. (2012), Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140. PLoS ONE, 7(7):e41144.
PMID: 22829921
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2012), Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 109(25):9971-6.
PMID: 22665806
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bartemes KR et al. (2011), IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J. Immunol., 188(3):1503-13.
PMID: 22198948
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cao W et al. (2011), Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity, 35(2):273-84.
PMID: 21835648
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Monticelli LA et al. (2011), Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat. Immunol., 12(11):1045-54.
PMID: 21946417
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Reddy PB et al. (2011), Influence of galectin-9/Tim-3 interaction on herpes simplex virus-1 latency. J. Immunol., 187(11):5745-55.
PMID: 22021615
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kashiwada M et al. (2011), NFIL3/E4BP4 controls type 2 T helper cell cytokine expression. EMBO J., 30(10):2071-82.
PMID: 21499227
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

El-Behi M et al. (2011), The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol., 12(6):568-75.
PMID: 21516111
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Smith C et al. (2011), Differential outcome of IL-2/anti-IL-2 complex therapy on effector and memory CD8+ T cells following vaccination with an adenoviral vector encoding EBV epitopes. J. Immunol., 186(10):5784-90.
PMID: 21482735
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Emoto M et al. (2010), Dissociated expression of natural killer 1.1 and T-cell receptor by invariant natural killer T cells after interleukin-12 receptor and T-cell receptor signalling. Immunology, 129(1):62-74.
PMID: 20028429
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Filardy AA et al. (2010), Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages. J. Immunol., 185(4):2044-50.
PMID: 20660352
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Humrich JY et al. (2010), Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Proc. Natl. Acad. Sci. U.S.A., 107(1):204-9.
PMID: 20018660
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Kayamuro H et al. (2010), Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 84(24):12703-12.
PMID: 20881038
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wildbaum G et al. (2010), Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17. Am. J. Pathol., 176(6):2764-75.
PMID: 20382706
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Purushothaman D et al. (2009), Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis. J. Exp. Med., 206(7):1515-23.
PMID: 19546249
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dienz O et al. (2009), The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J. Exp. Med., 206(1):69-78.
PMID: 19139170
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Yu J et al. (2009), CD94 defines phenotypically and functionally distinct mouse NK cell subsets. J. Immunol., 183(8):4968-74.
PMID: 19801519
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

McKinley L et al. (2008), TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol., 181(6):4089-97.
PMID: 18768865
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Takada A et al. (2008), Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. J. Immunol., 180(3):1678-85.
PMID: 18209064
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kaya Z et al. (2008), Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis. Circulation, 118(20):2063-72.
PMID: 18955666
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jacobsen EA et al. (2008), Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. J. Exp. Med., 205(3):699-710.
PMID: 18316417
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Seshasayee D et al. (2007), In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J. Clin. Invest., 117(12):3868-3878.
PMID: 18060034
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zheng SG et al. (2007), IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol., 178(4):2018-27.
PMID: 17277105
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yamanouchi J et al. (2007), Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat. Genet., 39(3):329-37.
PMID: 17277778
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Fujiwara M et al. (2007), T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways. J. Allergy Clin. Immunol., 119(3):662-70.
PMID: 17336616
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chiang YM et al. (2007), Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator. J Ethnopharmacol, 110(3):532-8.
PMID: 17101254
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Li W et al. (2007), Protection of CD8+ T cells from activation-induced cell death by IL-18. J. Leukoc. Biol., 82(1):142-51.
PMID: 17400610
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ruzek MC et al. (2007), Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo. Blood, 111(3):1726-34.
PMID: 18025149
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bheeshmachar G et al. (2006), Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells. J. Immunol., 177(8):5041-50.
PMID: 17015687
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

de la Fuente MA et al. (2006), 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. Mol. Cell. Biol., 26(14):5214-25.
PMID: 16809760
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kulms D et al. (2006), Ultraviolet radiation inhibits interleukin-2-induced tyrosine phosphorylation and the activation of STAT5 in T lymphocytes. J. Biol. Chem., 276(16):12849-55.
PMID: 11278301
Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Vugmeyster Y et al. (2006), A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys. Am. J. Pathol., 168(2):476-89.
PMID: 16436662
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Christensen JE et al. (2006), CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. J. Immunol., 176(7):4235-43.
PMID: 16547260
Ogawa K et al. (2006), Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages. J. Immunol., 177(10):6787-94.
PMID: 17082592
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Harrington et al. (2005), Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol, 6(11):1123-32.
PMID: 16200070
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Schleicher U et al. (2004), Control of Leishmania major in the absence of Tyk2 kinase. Eur. J. Immunol., 34(2):519-29.
PMID: 14768057
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kipnis J et al. (2004), Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration. J. Neurosci., 24(27):6133-43.
PMID: 15240805
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Brady J et al. (2004), IL-21 induces the functional maturation of murine NK cells. J. Immunol., 172(4):2048-58.
PMID: 14764669
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

La Cava A et al. (2004), Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA. J. Immunol., 173(5):3542-8.
PMID: 15322219
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Upadhya S et al. (2004), Atherogenic effect of interleukin-2 and antiatherogenic effect of interleukin-2 antibody in apo-E-deficient mice. Angiology, 55(3):289-94.
PMID: 15156262
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nguyen P et al. (2003), Identification of a murine CD28 dileucine motif that suppresses single-chain chimeric T-cell receptor expression and function. Blood, 102(13):4320-5.
PMID: 12946999

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