Recombinant Mouse IL-13 Protein

Name: Recombinant Mouse IL-13 Protein
Brand: R&D Systems
SKU: 413-ML
Rating: 5 (6 reviews)

R&D Systems, Inc. a Bio-Techne Brand

Catalog # 413-ML

Citations (81)

(6)

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Key Product Details

Source:	E. coli
Accession #:	P20109
Applications:	Bioactivity

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Product Specifications for Recombinant Mouse IL-13 Protein

Source	E. coli-derived mouse IL-13 protein Ser26-Phe131
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin level	<0.01 EU per 1 μg of the protein by the LAL method.
N-terminal sequence Analysis	Ser26
Predicted Molecular Mass	11.5 kDa
SDS-PAGE	9 kDa, reducing conditions
Activity	Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED₅₀ for this effect is 0.75‑3 ng/mL.

Scientific Data Examples for Recombinant Mouse IL-13 Protein

	Recombinant Mouse IL-13 Protein Bioactivity Recombinant Mouse IL-13 (Catalog # 413-ML) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED₅₀ for this effect is 0.75-3 ng/mL.
	Recombinant Mouse IL-13 Protein SDS-PAGE 1 μg/lane of Recombinant Mouse IL-13 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 9 kDa.

Formulation, Preparation and Storage

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

413-ML

Carrier

Formulation	Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
Reconstitution	Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

413-ML/CF

Carrier Free

Formulation	Lyophilized from a 0.2 μm filtered solution in PBS. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS.
Reconstitution	Reconstitute 5 µg vials at 50 µg/mL in sterile PBS. Reconstitute 25 µg or larger vials at 100 µg/mL in sterile PBS.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-13

IL-13 is a 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergic asthma and atopy. It is secreted by Th1 and Th2 CD4⁺ T cells, NK cells, visceral smooth muscle cells, eosinophils, mast cells, and basophils (1 - 3). IL-13 circulates as a monomer with two internal disulfide bonds that contribute to a bundled four alpha -helix configuration (4, 5). Mature mouse IL-13 shares 57%, 75%, and 58% amino acid sequence identity with human, rat, and rhesus IL-13, respectively. Despite the low homology, it exhibits cross-species activity between human, mouse, and rat (6, 7). IL-13 has diverse activities on numerous cell types (8). On macrophages, IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances. On B cells, IL-13 induces immunoglobulin class switching to IgE, upregulates the expression of MHC class II, CD71, CD72, and CD23, and costimulates proliferation. IL-13 upregulates IL-6 while downregulating IL-1 and TNF-alpha production by fibroblasts and endothelial cells. IL-13 binds with low affinity to IL-13 R alpha 1, triggering IL-13 R alpha 1 association with IL-4 R alpha. This high affinity receptor complex also functions as the type 2 IL-4 receptor complex (9, 10). Additionally, IL-13 binds with high affinity to IL-13 R alpha 2 which is expressed intracellularly, on the cell surface, and as a soluble molecule (11 - 14). IL-13 R alpha 2 regulates the bioavailability of both IL-13 and IL-4 and is overexpressed in glioma and several bronchial pathologies (10, 15, 16). Compared to wild type IL-13, the atopy-associated R110Q variant of IL-13 elicits increased responsiveness from eosinophils that express low levels of IL-13 R alpha 2 (17).

Item	Value
References	Wills-Karp, M. (2004) Immunol. Rev. 202:175. Nakajima, H. and K. Takatsu (2007) Int. Arch. Allergy Immunol. 142:265. Brown, K.D. et al. (1989) J. Immunol. 142:679. Moy, F.J. et al. (2001) J. Mol. Biol. 310:219. Eisenmesser, E.Z. et al. (2001) J. Mol. Biol. 310:231. Ruetten, H. and C. Thiemermann (1997) Shock 8:409. Lakkis, F.G. et al. (1997) Biochem. Biophys. Res. Commun. 235:529. Wynn, T.A. (2003) Annu. Rev. Immunol. 21:425. Andrews, A.L. et al. (2002) J. Biol. Chem. 277:46073. Tabata, Y. et al. (2007) Curr. Allergy Asthma Rep. 7:338. Chiaramonte, M.G. et al. (2003) J. Exp. Med. 197:687. Daines, M.O. and G.K. Hershey (2002) J. Biol. Chem. 227:10387. Matsumura, M. et al. (2007) Biochem. Biophys. Res. Commun. 360:464. Tabata, Y. et al. (2007) J. Immunol. 177:7905. Andrews, A.L. et al. (2006) J. Allergy Clin. Immunol. 118:858. Joshi, B.H. et al. (2006) Vitam. Horm. 74:479. Andrews, A.-L. et al. (2007) J. Allergy Clin. Immunol. 120:91.
Long Name	Interleukin 13
Entrez Gene IDs	3596 (Human); 16163 (Mouse); 116553 (Rat); 574325 (Primate)
Alternate Names	ALRHMGC116789, BHR1interleukin-13, IL-13, IL-13MGC116788, IL13, MGC116786, NC30, P600, interleukin 13

Citations for Recombinant Mouse IL-13 Protein (81)

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Citations are publications that use Bio-Techne products. Selected citations for Recombinant Mouse IL-13 Protein include:

Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Y Inoue et al. (2022), Macrophage-Specific, Mafb-Deficient Mice Showed Delayed Skin Wound Healing International Journal of Molecular Sciences, 23(16).
PMID: 36012611
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AP Leinroth et al. (2022), Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations Cell Reports, 39(6):110785.
PMID: 35545045
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MK Ameka et al. (2022), An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload International Journal of Molecular Sciences, 23(13).
PMID: 35806422
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R Guo et al. (2022), Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation Theranostics, 12(11):5220-5236.
PMID: 35836819
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Qadri et al. (2021), Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration Arthritis Research Therapy, 2021;23(1):241.
PMID: 34521469
Species: Mouse
Sample Types: Whole Cells
Applications: Polarization

X Xiao et al. (2021), Dihydroartemisinin inhibits Lewis Lung carcinoma progression by inducing macrophages M1 polarization via AKT/mTOR pathway International immunopharmacology, 103(0):108427.
PMID: 34922249
Species: Mouse
Sample Types: Whole Cell
Applications: Bioassay

RD Hu et al. (2021), Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity Cell Death Disease, 2021;12(11):1023.
PMID: 34716308
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

CN Noto et al. (2021), IL-13 acts directly on gastric epithelial cells to promote metaplasia development during chronic gastritis Cellular and Molecular Gastroenterology and Hepatology, 0(0).
PMID: 34587523
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

V Delprat et al. (2020), Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway Sci Rep, 10(1):882.
PMID: 31964911
Species: Transgenic Mouse
Sample Types: Spheroid
Applications: Bioassay

AE Engler et al. (2020), Airway-Associated Macrophages in Homeostasis and Repair Cell Reports, 33(13):108553.
PMID: 33378665
Species: Mouse
Sample Types: In Vivo
Applications: Bioassay

P Raju et al. (2020), Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice J. Clin. Invest., 0(0).
PMID: 32516134
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JPM Luiz et al. (2020), MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression J. Leukoc. Biol., 0(0).
PMID: 32745297
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Paduch et al. (2019), Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1 J. Immunol., 0(0).
PMID: 30665936
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Fonseca et al. (2019), Group 2 innate lymphoid cells (ILC2) are regulated by stem cell factor during chronic asthmatic disease Mucosal Immunol, 12(2):445-456.
PMID: 30617299
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

PAM Cavalcante et al. (2019), Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein Mediators Inflamm., 2019(0):9086758.
PMID: 31360120
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CP Hans et al. (2019), Transcriptomics Analysis Reveals New Insights into the Roles of Notch1 Signaling on Macrophage Polarization Sci Rep, 9(1):7999.
PMID: 31142802
Species: Mouse
Sample Types: Organoids
Applications: Bioassay

Y Kasagi et al. (2018), The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelialï¿½Changes Cell Mol Gastroenterol Hepatol, 5(3):333-352.
PMID: 29552622
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Wan et al. (2018), Chi3l3: a potential key orchestrator of eosinophil recruitment in meningitis induced by Angiostrongylus cantonensis J Neuroinflammation, 15(1):31.
PMID: 29391024
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Farruggia et al. (2018), Astaxanthin exerts anti-inflammatory and antioxidant effects in macrophages in NRF2-dependent and independent manners J. Nutr. Biochem., 62(0):202-209.
PMID: 30308382
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R Sugamata et al. (2018), Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide J. Immunol., 0(0).
PMID: 30559322
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Y Ito et al. (2018), Toll-Interacting Protein, Tollip, Inhibits IL-13-Mediated Pulmonary Eosinophilic Inflammation in Mice J Innate Immun, 0(0).
PMID: 29393212
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Li et al. (2018), MicroRNA-let-7e regulates the progression and development of allergic rhinitis by targeting suppressor of cytokine signaling 4 and activating Janus kinase 1/signal transducer and activator of transcription 3 pathway Exp Ther Med, 15(4):3523-3529.
PMID: 29545878
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Kobori et al. (2018), Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis Front Immunol, 9(0):334.
PMID: 29559970
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

A Das et al. (2018), High-Resolution Mapping and Dynamics of the Transcriptome, Transcription Factors, and Transcription Co-Factor Networks in Classically and Alternatively Activated Macrophages Front Immunol, 9(0):22.
PMID: 29403501
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Chia et al. (2018), Enhanced Pro-Inflammatory Response of Macrophages to Interleukin-33 in an Allergic Environment Int. Arch. Allergy Immunol., 0(0).
PMID: 29621782
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Kerrinnes et al. (2017), Utilization of host polyamines in alternatively activated macrophages promotes chronic infection by Brucella abortus Infect. Immun., 0(0).
PMID: 29203548
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Ng Kuet Le et al. (2017), Crosstalk between glucocorticoids and IL-4 modulates Ym1 expression in alternatively activated myeloid cells Immunobiology, 0(0).
PMID: 28209270
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Sezaki et al. (2017), Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice World J. Gastroenterol., 23(13):2294-2307.
PMID: 28428709
Species: Mouse
Sample Types: Serum
Applications: ELISA (Standard)

W Dawicki et al. (2017), Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3(+)CD49b(-)Foxp3(-) regulatory Tï¿½cells J. Allergy Clin. Immunol., 139(5):1608-1620.e3.
PMID: 28277274
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SC Sebag et al. (2017), Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma JCI Insight, 2(3):e88297.
PMID: 28194433
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R Bruen et al. (2017), Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis Cardiovasc Diabetol, 16(1):143.
PMID: 29110715
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AS Morris et al. (2017), Cationic CaMKII Inhibiting Nanoparticles Prevent Allergic Asthma Mol. Pharm., 0(0).
PMID: 28460526
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CA Sorgi et al. (2017), Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid Sci Rep, 7(1):10981.
PMID: 28887514
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

H Yang et al. (2017), Interleukin-13 reduces cardiac injury and prevents heart dysfunction in viral myocarditis via enhanced M2 macrophage polarization Oncotarget, 8(59):99495-99503.
PMID: 29245918
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Nasti et al. (2017), The CD45(+) fraction in murine adipose tissue-derived stromal cells harbor immune-inhibitory inflammatory cells Eur. J. Immunol., 0(0).
PMID: 28891216
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

T Eddens et al. (2017), Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity Cell Rep, 18(13):3078-3090.
PMID: 28355561
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

DC Nascimento et al. (2017), IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population Nat Commun, 8(0):14919.
PMID: 28374774
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Niels Olsen Saraiva Camara (2016), Early infiltration of p40IL12(+)CCR7(+)CD11b(+) cells is critical for fibrosis development Immun Inflamm Dis, 4(3):300-14.
PMID: 27621813
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy J. Immunol., 197(12):4750-4761.
PMID: 27913649
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), IL4RA on lymphatic endothelial cells promotes T cell egress during sclerodermatous graft versus host disease JCI Insight, 1(12).
PMID: 27547823
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016), Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections Sci Rep, 6(0):37211.
PMID: 27845414
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ballinger M et al. (2015), IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury. J Immunol, 194(4):1894-904.
PMID: 25595781
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Liu K et al. (2015), Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization. Autophagy, 11(2):271-84.
PMID: 25650776
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wu K et al. (2015), TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J Exp Med, 212(5):681-97.
PMID: 25897174
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Luminex (Standard)

Shibata T et al. (2014), Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma. J Immunol, 192(8):3569-81.
PMID: 24659691
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cao Q et al. (2014), Failed renoprotection by alternatively activated bone marrow macrophages is due to a proliferation-dependent phenotype switch in vivo. Kidney Int, 85(4):794-806.
PMID: 24048378
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Stouch A et al. (2014), IkappaB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm. J Immunol, 193(3):1184-93.
PMID: 24981452
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hiroshima Y et al. (2014), S100A8 induces IL-10 and protects against acute lung injury. J Immunol, 192(6):2800-11.
PMID: 24532576
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sahin E et al. (2014), Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses. J Immunol, 193(4):1717-27.
PMID: 25015834
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Veremeyko et al. (2013), IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation. PLoS ONE, 8(12):e81774.
PMID: 24358127
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Palm N et al. (2013), Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity, 39(5):976-85.
PMID: 24210353
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

McHedlidze T et al. (2013), Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity, 39(2):357-71.
PMID: 23954132
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Starkey M et al. (2013), Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease. Mucosal Immunol, 6(3):569-79.
PMID: 23131786
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Mabalirajan U et al. (2013), 12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma. Sci Rep, 3(0):1540.
PMID: 23528921
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Suzukawa M et al. (2012), Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, Is crucial for murine asthma. J Immunol, 189(7):3641-52.
PMID: 22942422
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2012), Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 109(25):9971-6.
PMID: 22665806
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Oh MH et al. (2011), IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. J. Immunol., 186(12):7232-42.
PMID: 21576506
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Taube C et al. (2011), IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease. PLoS ONE, 6(7):e21799.
PMID: 21789181
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Monticelli LA et al. (2011), Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat. Immunol., 12(11):1045-54.
PMID: 21946417
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Asquith KL et al. (2011), Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts. PLoS Pathog., 7(5):e1001339.
PMID: 21573182
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sehra S et al. (2010), Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J. Immunol., 186(8):4959-66.
PMID: 21402898
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Zhao A et al. (2010), Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J. Immunol., 185(0):6921-9.
PMID: 20974983
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Horvat JC et al. (2010), Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. J. Immunol., 184(8):4159-69.
PMID: 20228193
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Mosconi E et al. (2010), Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development. Mucosal Immunol, 3(5):461-74.
PMID: 20485331
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Kayamuro H et al. (2010), Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 84(24):12703-12.
PMID: 20881038
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Miyata M et al. (2009), Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation. Eur. J. Immunol., 39(11):3078-83.
PMID: 19658093
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Neveu WA et al. (2009), IL-6 is required for airway mucus production induced by inhaled fungal allergens. J. Immunol., 183(3):1732-8.
PMID: 19592651
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Morimoto M et al. (2009), IL-13 receptor alpha2 regulates the immune and functional response to Nippostrongylus brasiliensis infection. J. Immunol., 183(3):1934-9.
PMID: 19587021
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Miller R et al. (2008), Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay. J. Immunol. Methods, 334(1):134-41.
PMID: 18355834
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hudson CA et al. (2008), Induction of IL-33 expression and activity in central nervous system glia. J. Leukoc. Biol., 84(3):631-43.
PMID: 18552204
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Khaled WT et al. (2007), The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development. Development, 134(15):2739-50.
PMID: 17611223
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Howell MD et al. (2006), Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity, 24(3):341-8.
PMID: 16546102
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Lama VN et al. (2006), Obligatory role for interleukin-13 in obstructive lesion development in airway allografts. Am. J. Pathol., 169(1):47-60.
PMID: 16816360
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Wen H et al. (2006), Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile. Am. J. Pathol., 168(6):1940-50.
PMID: 16723709
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Schmitz J et al. (2005), IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity, 23(5):479-90.
PMID: 16286016
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Huaux F et al. (2003), Dual roles of IL-4 in lung injury and fibrosis. J. Immunol., 170(4):2083-92.
PMID: 12574379
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Jakubzick C et al. (2003), Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of Th1- and Th2-type pulmonary granuloma fibroblasts. Am. J. Pathol., 162(5):1475-86.
PMID: 12707030
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Herrick CA et al. (2003), IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen. J. Immunol., 170(5):2488-95.
PMID: 12594274
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Larbi KY et al. (2003), P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses. J. Leukoc. Biol., 73(1):65-73.
PMID: 12525563
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Shi ZO et al. (2002), IFN-gamma, but not Fas, mediates reduction of allergen-induced mucous cell metaplasia by inducing apoptosis. J. Immunol., 168(9):4764-71.
PMID: 11971027
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Kim S et al. (2002), IL-13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway. Am. J. Physiol. Lung Cell Mol. Physiol., 283(1):L67-75.
PMID: 12060562

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Application: CellProlif

Verified Customer | Posted 10/13/2021
Recombinant Mouse IL-13 Protein

Name: Anonymous

Application: In vitro bioactivity in cell culture

Verified Customer | Posted 04/13/2021
Recombinant Mouse IL-13 Protein

Name: Anonymous

Application: In vitro bioactivity in cell culture

Verified Customer | Posted 01/27/2021
Recombinant Mouse IL-13 Protein

Name: Sherry Niu

Application: Stem/Immune cell maintenance or differentiation

Verified Customer | Posted 10/23/2020
Recombinant Mouse IL-13 Protein

Name: Anonymous

Application: In vivo study

Verified Customer | Posted 12/18/2019

mIL-13 induces CCL11 expression
Recombinant Mouse IL-13 Protein

Name: Anonymous

Application: In vivo study

Reason for Rating: works well in mouse model

Verified Customer | Posted 12/10/2019

Recombinant Mouse IL-13 Protein

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413-ML

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413-ML/CF

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Background: IL-13

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Recombinant Mouse IL-13 Protein

Recombinant Mouse IL-13 Protein

Recombinant Mouse IL-13 Protein

Recombinant Mouse IL-13 Protein

Recombinant Mouse IL-13 Protein

Recombinant Mouse IL-13 Protein

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