Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha
R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Source: | E. coli |
Accession #: | P48061 |
Applications: | Bioactivity |
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Citations for Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha (169)
Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha include:
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Species: Mouse
Sample Types: Whole Cells
Applications: BioassayML Capitano et al. (2022), DEK, a nuclear protein, is chemotactic for hematopoietic stem/progenitor cells acting through CXCR2 and Galphai signaling Journal of leukocyte biology, 0(0).
PMID: 35137444 -
Species: Human
Sample Types: Whole Cell
Applications: BioassayTA Burley et al. (2022), Elucidation of Focal Adhesion Kinase as a Modulator of Migration and Invasion and as a Potential Therapeutic Target in Chronic Lymphocytic Leukemia Cancers, 14(7).
PMID: 35406371 -
Species: Mouse
Sample Types: Bone Marrow Lavage Fluid
Applications: ELISA ControlC Fielding et al. (2022), Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis Nature Communications, 13(1):543.
PMID: 35087060 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Mastrogiov et al. (2022), The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration Science Advances, 8(15):eabl5942.
PMID: 35417240 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Xu et al. (2022), Discovery of Small Molecule Activators of Chemokine Receptor CXCR4 That Improve Diabetic Wound Healing International Journal of Molecular Sciences, 23(4).
PMID: 35216311 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Leng et al. (2022), Inflammation down regulates stromal cell-derived factor 1alpha in the early phase of pulpitis Cytokine, 158(0):155983.
PMID: 35930964 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Tobiume et al. (2022), Analysis of the chemotactic factors for tumor-infiltrating fibrocytes and their prognostic significances in lung cancer Oncology Letters, 24(5):417.
PMID: 36245829 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Yuan et al. (2022), SDF?1alpha/CXCR4 signaling promotes capillary tube formation of human retinal vascular endothelial cells by activating ERK1/2 and PI3K pathways in�vitro Molecular Medicine Reports, 26(4).
PMID: 35946444 -
Species: Rat
Sample Types: Whole Tissue
Applications: BioassayK Bassand et al. (2021), miR-126-3p is essential for CXCL12-induced angiogenesis Journal of Cellular and Molecular Medicine, 0(0).
PMID: 34117709 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Yuzuriha et al. (2021), Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin &beta1-ILK-&beta-catenin-JUN axis Stem Cell Research, 53(0):102287.
PMID: 33813173 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Berrazouan et al. (2021), VLA-4 Induces Chemoresistance of T Cell Acute Lymphoblastic Leukemia Cells via PYK2-Mediated Drug Efflux Cancers, 13(14).
PMID: 34298726 -
Species: Mouse
Sample Types: Organoid
Applications: BioassayLA Ridge et al. (2021), Dual role for CXCL12 signaling in semilunar valve development Cell Reports, 36(8):109610.
PMID: 34433040 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Radaszkiew et al. (2021), RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy Elife, 10(0).
PMID: 34702444 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayW Feng et al. (2021), CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3 Theranostics, 11(6):2612-2633.
PMID: 33456563 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJY Kim et al. (2021), CXCR4 uses STAT3-mediated slug expression to maintain radioresistance of non-small cell lung cancer cells: emerges as a potential prognostic biomarker for lung cancer Cell Death Disease, 2021;12(1):48.
PMID: 33414415 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Fu et al. (2021), CD27-CD38+ B cells accumulated in early HIV infection exhibit transitional profile and promote HIV disease progression Cell Reports, 36(2):109344.
PMID: 34260905 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayH Levy-Baraz et al. (2020), Brief ex vivo Fas-ligand incubation attenuates GvHD without compromising stem cell graft performance Bone Marrow Transplant., 0(0).
PMID: 32433499 -
Species: Human
Applications: Functional AssayL Chen et al. (2020), CXCR4 upregulation is an indicator of sensitivity to B-cell receptor/PI3K blockade and a potential resistance mechanism in B-cell receptor-dependent diffuse large B-cell lymphomas Haematologica, 105(5):1361-1368.
PMID: 31471373 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Wang et al. (2020), LRCH1 suppresses migration of CD4+ T cells and refers to disease activity in ulcerative colitis Int J Med Sci, 17(5):599-608.
PMID: 32210709 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayAA Chimote et al. (2020), A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer Front Pharmacol, 11(0):143.
PMID: 32184726 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureH Cho et al. (2020), iPSC-derived endothelial cell response to hypoxia via SDF1a/CXCR4 axis facilitates incorporation to revascularize ischemic retina JCI Insight, 5(6).
PMID: 32213707 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayD Biasci et al. (2020), CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response Proc Natl Acad Sci U S A, 0(0).
PMID: 33127761 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Fumagalli et al. (2020), The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication Nat Commun, 11(1):4855.
PMID: 32978390 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPR Norden et al. (2020), Control of endothelial tubulogenesis by Rab and Ral GTPases, and apical targeting of caveolin-1-labeled vacuoles PLoS ONE, 15(6):e0235116.
PMID: 32569321 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Lim et al. (2020), Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1-NRF2 pathway Sci Adv, 6(16):eaba1334.
PMID: 32490200 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Iseoka et al. (2020), Role and therapeutic effects of skeletal muscle-derived non-myogenic cells in a rat myocardial infarction model Stem Cell Res Ther, 11(1):69.
PMID: 32070429 -
Species: Human
Sample Types: Protein
Applications: BioassayJ O'Dwyer et al. (2020), Development of a Sustained Release Nano-In-Gel Delivery System for the Chemotactic and Angiogenic Growth Factor Stromal-Derived Factor 1alpha Pharmaceutics, 12(6).
PMID: 32512712 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMJ Costa et al. (2019), Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates Sci Rep, 9(1):2443.
PMID: 30792442 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Li et al. (2019), Activation of MAPK signaling by CXCR7 leads to enzalutamide resistance in prostate cancer Cancer Res., 0(0).
PMID: 30952632 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayW Liu et al. (2019), RhoGDI2 positively regulates the Rho GTPases activation in response to the ?2 outside-in signaling in T cells adhesion and migration on ICAM-1 J. Leukoc. Biol., 0(0).
PMID: 31075185 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayML Capitano et al. (2019), Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling J. Clin. Invest., 130(0):2555-2570.
PMID: 31107242 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoC Ieranò et al. (2019), CXCL12 loaded-dermal filler captures CXCR4 expressing melanoma circulating tumor cells Cell Death Dis, 10(8):562.
PMID: 31332163 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Yang et al. (2019), TCF12 promotes the tumorigenesis and metastasis of hepatocellular carcinoma via upregulation of CXCR4 expression Theranostics, 9(20):5810-5827.
PMID: 31534521 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayNM Belle et al. (2019), TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths Nat Commun, 10(1):4408.
PMID: 31562318 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayF Caccuri et al. (2019), The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3) Int J Mol Sci, 20(21).
PMID: 31653015 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLA Callender et al. (2019), Mitochondrial mass governs the extent of human T cell senescence Aging Cell, 0(0):e13067.
PMID: 31788930 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPD Fromm et al. (2019), Distinguishing human peripheral blood CD16+ myeloid cells based on phenotypic characteristics J. Leukoc. Biol., 0(0).
PMID: 31749181 -
Species: Human
Sample Types: Recombinant Protein
Applications: Positive ControlDJ Wessels et al. (2019), Reciprocal signaling and direct physical interactions between fibroblasts and breast cancer cells in a 3D environment PLoS ONE, 14(6):e0218854.
PMID: 31233557 -
Sample Types: Whole Cells
Applications: BioassayF Jahan et al. (2018), Phosphorylation of the ?-chain in the integrin LFA-1 enables ?2-chain phosphorylation and ?-actinin binding required for cell adhesion J. Biol. Chem., 0(0).
PMID: 29903913 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTI Moore et al. (2018), Measuring Integrin Conformational Change on the Cell Surface with Super-Resolution Microscopy Cell Rep, 22(7):1903-1912.
PMID: 29444440 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayW Tang et al. (2018), Interleukin-25 and eosinophils progenitor cell mobilization in allergic asthma Clin Transl Allergy, 8(0):5.
PMID: 29456832 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJJ Gell et al. (2018), PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation Stem Cell Res, 27(0):46-56.
PMID: 29324254 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Patalano et al. (2018), CXCL12/CXCR4-Mediated Procollagen Secretion Is Coupled To Cullin-RING Ubiquitin Ligase Activation Sci Rep, 8(1):3499.
PMID: 29472636 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Nam et al. (2018), Intraperitoneal infusion of mesenchymal stem cell attenuates severity of collagen antibody induced arthritis PLoS ONE, 13(6):e0198740.
PMID: 29879214 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKM Dvorak et al. (2018), Carcinoma associated fibroblasts (CAFs) promote breast cancer motility by suppressing mammalian Diaphanous-related formin-2 (mDia2) PLoS ONE, 13(3):e0195278.
PMID: 29596520 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Ohta et al. (2018), Simple Physical Model Unravels Influences of Chemokine on Shape Deformation and Migration of Human Hematopoietic Stem Cells Sci Rep, 8(1):10630.
PMID: 30006633 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoE Vågesjö et al. (2018), Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 29432190 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySYN Jamaludin et al. (2018), Assessment of CXC ligand 12-mediated calcium signalling and its regulators in basal-like breast cancer cells Oncol Lett, 15(4):4289-4295.
PMID: 29541196 -
BL Benson et al. (2018), Biomimetic post-capillary venule expansions for leukocyte adhesion studies Sci Rep, 8(1):9328.
PMID: 29921896 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayW He et al. (2018), Targeting CXC motif chemokine receptor 4 inhibits the proliferation, migration and angiogenesis of lung cancer cells Oncol Lett, 16(3):3976-3982.
PMID: 30128017 -
Species: Human
Sample Types: Whole Cells
S Mamand et al. (2018), Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma Sci Rep, 8(1):14216.
PMID: 30242208 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Bao et al. (2018), A feed-forward loop between nuclear translocation of CXCR4 and HIF-1? promotes renal cell carcinoma metastasis Oncogene, 0(0).
PMID: 30177838 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLF Pavon et al. (2018), Tropism of mesenchymal stem cell toward CD133+ stem cell of glioblastoma in vitro and promote tumor proliferation in vivo Stem Cell Res Ther, 9(1):310.
PMID: 30413179 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJE Yoon et al. (2018), Senescent fibroblasts drive ageing pigmentation: ?A potential therapeutic target for senile lentigo Theranostics, 8(17):4620-4632.
PMID: 30279727 -
Species: Feline
Sample Types: Whole Cells
Applications: BioassayJL Rojo et al. (2018), Stromal-derived factor 1 directly promotes genes expressed within the ovulatory cascade in feline cumulus oocyte complexes J. Assist. Reprod. Genet., 0(0).
PMID: 29516335 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Sun et al. (2018), Transmission of integrin ?7 transmembrane domain topology enables gut lymphoid tissue development J. Cell Biol., 0(0).
PMID: 29535192 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Giarra et al. (2018), Engineering of thermoresponsive gels as a fake metastatic niche Carbohydr Polym, 191(0):112-118.
PMID: 29661298 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Plešingero et al. (2017), Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia Haematologica, 0(0).
PMID: 29122990 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayXJ Li et al. (2017), Mechanisms of CXCR7 induction in malignant melanoma development Oncol Lett, 14(4):4106-4114.
PMID: 28943917 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Veenstra et al. (2017), Frontline Science: CXCR7 mediates CD14(+)CD16(+) monocyte transmigration across the blood brain barrier: a potential therapeutic target for NeuroAIDS J. Leukoc. Biol., 0(0).
PMID: 28754798 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayPJ Stewart-Hu et al. (2017), Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate J. Leukoc. Biol., 0(0).
PMID: 28637896 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayE Crompot et al. (2017), Extracellular vesicles of bone marrow stromal cells rescue chronic lymphocytic leukemia B-cells from apoptosis, enhance their migration and induce gene expression modifications Haematologica, 0(0).
PMID: 28596280 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayW Chen et al. (2017), Directional delivery of RSPO1 by mesenchymal stem cells ameliorates radiation-induced intestinal injury Cytokine, 95(0):27-34.
PMID: 28214675 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Al Faruque et al. (2017), Stepwise inhibition of T cell recruitment at post-capillary venules by orally active desulfated heparins in inflammatory arthritis PLoS ONE, 12(4):e0176110.
PMID: 28419144 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Liu et al. (2017), Endothelial progenitor cell dysfunction in acute exacerbation of chronic obstructive pulmonary disease Mol Med Rep, 0(0).
PMID: 28849108 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Zhang et al. (2017), CXCL12 enhances angiogenesis through CXCR7 activation in human umbilical vein endothelial cells Sci Rep, 7(1):8289.
PMID: 28811579 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJH Kim et al. (2017), Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells Sci Rep, 7(1):2798.
PMID: 28584306 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Park et al. (2017), Directional migration of mesenchymal stem cells under an SDF-1? gradient on a microfluidic device PLoS ONE, 12(9):e0184595.
PMID: 28886159 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Müller et al. (2017), Designed cell consortia as fragrance-programmable analog-to-digital converters Nat. Chem. Biol, 0(0).
PMID: 28092361 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2017), MicroRNA expression profiles and networks in CXCL12?stimulated human endometrial stromal cells Mol Med Rep, 15(1):249-255.
PMID: 27959395 -
Species: Human
Sample Types: Antibody
Applications: Enzyme AssayDI Bromage et al. (2017), A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies PLoS ONE, 12(4):e0174447.
PMID: 28379992 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayD Kobayashi et al. (2017), Regulation of CCR7-dependent cell migration through�CCR7 homodimer formation Sci Rep, 7(1):8536.
PMID: 28819198 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZ Jiang et al. (2017), Protein profiling identified key chemokines that regulate the maintenance of human pluripotent stem cells Sci Rep, 7(1):14510.
PMID: 29109449 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Wang et al. (2017), Hepatitis B virus X protein promotes the stem-like properties of OV6(+) cancer cells in hepatocellular carcinoma Cell Death Dis, 8(1):e2560.
PMID: 28102846 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Xu et al. (2017), Vascular CXCR4 expression promotes vessel sprouting and sensitivity to sorafenib treatment in hepatocellular carcinoma Clin. Cancer Res, 0(0).
PMID: 28223275 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Strazza et al. (2017), PLC?1 regulates SDF-1?-induced lymphocyte adhesion and migration to sites of inflammation Proc. Natl. Acad. Sci. U.S.A, 0(0).
PMID: 28213494 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayW Oliva-Oliv et al. (2017), Different response to hypoxia of adipose-derived multipotent cells from obese subjects with and without metabolic syndrome PLoS ONE, 12(11):e0188324.
PMID: 29166648 -
Species: Human
Sample Types: Recombinant Protein
Applications: BioassayR Desplantes et al. (2017), Affinity biosensors using recombinant native membrane proteins displayed on exosomes: application to botulinum neurotoxin B receptor Sci Rep, 7(1):1032.
PMID: 28432329 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Drouillard et al. (2017), Human Naive and Memory T Cells Display Opposite Migratory Responses to Sphingosine-1 Phosphate J. Immunol., 0(0).
PMID: 29237776 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Moslem et al. (2017), Kindlin-2 Modulates the Survival, Differentiation, and Migration of Induced Pluripotent Cell-Derived Mesenchymal Stromal Cells Stem Cells Int, 2017(0):7316354.
PMID: 28163724 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMT Logun et al. (2016), Glioma Cell Invasion is Significantly Enhanced in Composite Hydrogel Matrices Composed of Chondroitin 4- and 4,6-Sulfated Glycosaminoglycans J Mater Chem B Mater Biol Med, 4(36):6052-6064.
PMID: 28217304 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPatricia Freund (2016), Cannabinoid Receptors Are Overexpressed in CLL but of Limited Potential for Therapeutic Exploitation PLoS ONE, 11(6):e0156693.
PMID: 27248492 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016), Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: Evidence for Partial Allosteric Agonism in Comparison to CXCL12 J Biol Chem, 0(0).
PMID: 27226569 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016), HEREGULIN/ErbB3 SIGNALING ENHANCES CXCR4-DRIVEN Rac1 ACTIVATION AND BREAST CANCER CELL MOTILITY VIA HIF-1? Mol Cell Biol, 0(0).
PMID: 27185877 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016), SDF-1?-induced dual pairs of E-selectin/ligand mediate endothelial progenitor cell homing to critical ischemia Sci Rep, 6(0):34416.
PMID: 27713493 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Velasquez et al. (2016), Pannexin1 Channels Are Required for Chemokine-Mediated Migration of CD4+ T Lymphocytes: Role in Inflammation and Experimental Autoimmune Encephalomyelitis J Immunol, 0(0).
PMID: 27076682 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassayXudong Shi (2016), Local CXCR4 Up-regulation in Injured Arterial Wall Contributes to Intimal Hyperplasia Stem Cells, 0(0).
PMID: 27340942 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRenren Bai (2016), Development of CXCR4 modulators by virtual HTS of a novel amide-sulfamide compound library Eur J Med Chem, 126(0):464-475.
PMID: 27914361 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayAmber N Stratman (2016), Mural-Endothelial cell-cell interactions stabilize the developing zebrafish dorsal aorta Development, 0(0).
PMID: 27913637 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJanovska P et al. (2016), Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia. Clin Cancer Res, 22(2):459-69.
PMID: 26240275 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHeinzmann D et al. (2015), The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis. PLoS ONE, 10(4):e0124606.
PMID: 25894208 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRay P et al. (2015), CXCL12-gamma in primary tumors drives breast cancer metastasis. Oncogene, 34(16):2043-51.
PMID: 24909174 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWilliams D et al. (2015), JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14+CD16+ monocytes in HIV-infected individuals. J Leukoc Biol, 97(2):401-12.
PMID: 25420915 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWalsh T et al. (2015), SDF-1alpha is a novel autocrine activator of platelets operating through its receptor CXCR4. Cell Signal, 27(1):37-46.
PMID: 25283599 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayChang T et al. (2015), Bortezomib inhibits expression of TGF-beta1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells. J Immunol, 194(6):2942-53.
PMID: 25681335 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayIlkow C et al. (2015), Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity. Nat Med, 21(5):530-6.
PMID: 25894825 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBoudot A et al. (2014), COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration. BMC Cancer, 14(0):407.
PMID: 24906407 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayVermi W et al. (2014), slanDCs selectively accumulate in carcinoma-draining lymph nodes and marginate metastatic cells. Nat Commun, 5(0):3029.
PMID: 24398631 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZucco L et al. (2014), Circulating angiogenic cell dysfunction in patients with hereditary hemorrhagic telangiectasia. PLoS ONE, 9(2):e89927.
PMID: 24587130 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWesterweel et al. (2014), Impaired endothelial progenitor cell mobilization and dysfunctional bone marrow stroma in diabetes mellitus. PLoS ONE, 8(3):e60357.
PMID: 23555959 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRichter R et al. (2014), Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells. Stem Cells Dev, 23(16):1959-74.
PMID: 24708339 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRuiz E et al. (2014), A paracrine network regulates the cross-talk between human lung stem cells and the stroma. Nat Commun, 5(0):3175.
PMID: 24430801 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayUgarte-Berzal E et al. (2014), A novel CD44-binding peptide from the pro-matrix metalloproteinase-9 hemopexin domain impairs adhesion and migration of chronic lymphocytic leukemia (CLL) cells. J Biol Chem, 289(22):15340-9.
PMID: 24739387 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKrook M et al. (2014), Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma. Mol Cancer Res, 12(6):953-64.
PMID: 24651452 -
Species: N/A
Sample Types: Chip
Applications: BioassayHoellenriegel J et al. (2014), The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization. Blood, 123(7):1032-9.
PMID: 24277076 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayGharaee-Kermani M et al. (2014), Complex cellular composition of solitary fibrous tumor of the prostate. Am J Pathol, 184(3):732-9.
PMID: 24434011 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayButschkau et al. (2014), Protein z exerts pro-angiogenic effects and upregulates CXCR4. PLoS ONE, 9(12):e113554.
PMID: 25474349 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCoggins N et al. (2014), CXCR7 controls competition for recruitment of beta-arrestin 2 in cells expressing both CXCR4 and CXCR7. PLoS ONE, 9(6):e98328.
PMID: 24896823 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLessey-Morillon E et al. (2014), The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration. J Immunol, 192(7):3390-8.
PMID: 24585879 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLo H et al. (2014), TNF-alpha induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin, 35(3):339-50.
PMID: 24487964 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayChigaev A et al. (2014), Carbon monoxide down-regulates alpha4beta1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization. BMC Immunol, 15(0):52.
PMID: 25367365 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayWatson H et al. (2014), Heparan sulfate inhibits hematopoietic stem and progenitor cell migration and engraftment in mucopolysaccharidosis I. J Biol Chem, 289(52):36194-203.
PMID: 25359774 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCheng et al. (2013), Distinct angiogenesis roles and surface markers of early and late endothelial progenitor cells revealed by functional group analyses. BMC Genomics, 14(0):182.
PMID: 23496821 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayAkimoto et al. (2013), Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal stem cells promote, glioblastoma multiforme proliferation. Stem Cells Dev, 22(9):1370-86.
PMID: 23231075 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRossi E et al. (2013), Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood, 121(2):403-15.
PMID: 23074273 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureWen W et al. (2013), Oligomannurarate sulfate inhibits CXCL12/SDF-1-mediated proliferation and invasion of human tumor cells in vitro. Acta Pharmacol Sin, 34(12):1554-9.
PMID: 24141568 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySmith A et al. (2013), Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions. PLoS ONE, 8(12):e85147.
PMID: 24391990 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureHoque et al. (2013), PCaAnalyser: a 2D-image analysis based module for effective determination of prostate cancer progression in 3D culture. PLoS ONE, 8(11):e79865.
PMID: 24278197 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTai Y et al. (2012), Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma. Blood, 120(9):1877-87.
PMID: 22689860 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2012), Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia. BMC Cancer, 12(0):431.
PMID: 23013471 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWilson TR et al. (2012), Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 487(7408):505-9.
PMID: 22763448 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBadr G et al. (2011), Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis. PLoS ONE, 6(9):e23741.
PMID: 21912642 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoFujita-Sato S et al. (2011), Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production. J. Biol. Chem., 286(36):31409-17.
PMID: 21733845 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayYasumoto K et al. (2011), The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer. Clin. Cancer Res., 17(11):3619-30.
PMID: 21482691 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBurton VJ et al. (2011), Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture. Exp. Cell Res., 317(3):276-92.
PMID: 21056557 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoFujio M et al. (2011), Stromal cell-derived factor-1 enhances distraction osteogenesis-mediated skeletal tissue regeneration through the recruitment of endothelial precursors. Bone, 49(4):693-700.
PMID: 21741502 -
Species: Rat
Sample Types: In Vivo
Applications: In VivoBenamar K et al. (2011), Analgesic efficacy of buprenorphine in the presence of high levels of SDF-1alpha/CXCL12 in the brain. Drug Alcohol Depend, 114(2):246-8.
PMID: 21112161 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCharles J et al. (2010), Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor. J. Invest. Dermatol., 130(6):1646-56.
PMID: 20220766 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHachehouche LN et al. (2010), Implication of discoidin domain receptor 1 in T cell migration in three-dimensional collagen. Mol. Immunol., 47(9):1866-9.
PMID: 20353877 -
Species: Human
Sample Types: Whole Cells
Applications: Binding AssayBerahovich RD et al. (2010), CXCR7 protein is not expressed on human or mouse leukocytes. J. Immunol., 185(9):5130-9.
PMID: 20889540 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKenig S et al. (2010), Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9. Cancer Lett., 289(1):53-61.
PMID: 19700239 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySengupta N et al. (2010), Paracrine modulation of CXCR4 by IGF-1 and VEGF: implications for choroidal neovascularization. Invest. Ophthalmol. Vis. Sci., 51(5):2697-704.
PMID: 20007826 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBoniface K et al. (2009), Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J. Exp. Med., 206(3):535-48.
PMID: 19273625 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoCrawford Y et al. (2009), PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell, 15(1):21-34.
PMID: 19111878 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayStratman AN et al. (2009), Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation. Blood, 114(24):5091-101.
PMID: 19822899 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySkrzeczynska-Moncznik J et al. (2009), Potential role of chemerin in recruitment of plasmacytoid dendritic cells to diseased skin. Biochem. Biophys. Res. Commun., 380(2):323-7.
PMID: 19168032 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayStruyf S et al. (2009), Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4. J. Immunol., 182(1):666-74.
PMID: 19109200 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZhu Y et al. (2009), CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. FASEB J., 23(9):2928-41.
PMID: 19380511 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHartl D et al. (2008), Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J. Immunol., 181(11):8053-67.
PMID: 19017998 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoKerfoot SM et al. (2008), Exogenous stromal cell-derived factor-1 induces modest leukocyte recruitment in vivo. Am. J. Physiol. Heart Circ. Physiol., 294(6):H2524-34.
PMID: 18424631 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayOuwehand K et al. (2008), CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis. Eur. J. Immunol., 38(11):3050-9.
PMID: 18924211 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayShojaei F et al. (2007), Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature, 450(7171):825-31.
PMID: 18064003 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBayry J et al. (2007), Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells. J. Immunol., 178(7):4184-93.
PMID: 17371975 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySchreiber TH et al. (2007), Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm. Blood, 109(4):1381-6.
PMID: 17038526 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoKaminski A et al. (2007), Endothelial NOS is required for SDF-1alpha/CXCR4-mediated peripheral endothelial adhesion of c-kit+ bone marrow stem cells. Lab. Invest., 88(1):58-69.
PMID: 18040270 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayMeyer EH et al. (2007), iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity. J. Immunol., 179(7):4661-71.
PMID: 17878364 -
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: BioassayIsakova IA et al. (2007), Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain. Stem Cells, 25(12):3261-70.
PMID: 17932418 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayPark EJ et al. (2007), Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. J. Clin. Invest., 117(9):2526-38.
PMID: 17786243 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayNakayama T et al. (2006), FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc. Blood, 109(4):1363-72.
PMID: 17077327 -
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)Peng H et al. (2006), HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta. Glia, 54(6):619-29.
PMID: 16944452 -
Species: Virus
Sample Types: Virus
Applications: Binding AssayNakayama T et al. (2006), Novel antiviral activity of chemokines. Virology, 350(2):484-92.
PMID: 16603217 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySaunders WB et al. (2006), Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J. Cell Biol., 175(1):179-91.
PMID: 17030988 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoAnghelina M et al. (2006), Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles. Am. J. Pathol., 168(2):529-41.
PMID: 16436667 -
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)Lisignoli G et al. (2006), Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54. J. Cell. Physiol., 207(2):364-73.
PMID: 16331675 -
Species: Rat
Sample Types: In Vivo
Applications: In VivoCarr AN et al. (2006), Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism. Cardiovasc. Res., 69(4):925-35.
PMID: 16409996 -
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)Infantino S et al. (2006), Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells. J. Immunol., 176(4):2197-207.
PMID: 16455976 -
Species: Rat
Sample Types: In Vivo
Applications: In VivoCarr AN et al. (2006), Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism. Cardiovasc. Res., 69(4):925-35.
PMID: 16409996 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMeller S et al. (2005), Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus. Arthritis Rheum., 52(5):1504-16.
PMID: 15880822 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoCorti S et al. (2005), Multipotentiality, homing properties, and pyramidal neurogenesis of CNS-derived LeX(ssea-1)+/CXCR4+ stem cells. FASEB J., 19(13):1860-2.
PMID: 16150803 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJanardhan A et al. (2004), HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis. PLoS Biol., 2(1):E6.
PMID: 14737186 -
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)Levesque JP et al. (2004), Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood, 104(1):65-72.
PMID: 15010367 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCuriel et al. (2004), Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med, 10(9):942-9.
PMID: 15322536 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayOkuma K et al. (2003), Development of a novel surrogate virus for human T-cell leukemia virus type 1: inhibition of infection by osteoprotegerin. J. Virol., 77(15):8562-9.
PMID: 12857926 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayVillalba S et al. (2003), Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo. J. Leukoc. Biol., 74(5):880-8.
PMID: 12960279 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHeissig B et al. (2002), Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell, 109(5):625-37.
PMID: 12062105 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHuber TB et al. (2002), Expression of functional CCR and CXCR chemokine receptors in podocytes. J. Immunol., 168(12):6244-52.
PMID: 12055238 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZamarchi R et al. (2002), Expression and functional activity of CXCR-4 and CCR-5 chemokine receptors in human thymocytes. 192, 127(2):321-30.
PMID: 11876757 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMisse D et al. (1999), A CD4-independent interaction of human immunodeficiency virus-1 gp120 with CXCR4 induces their cointernalization, cell signaling, and T-cell chemotaxis. Blood, 93(8):2454-62.
PMID: 10194422 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWellemans V et al. (0), Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells. iScienc24(12):103433.
PMID: 34917892
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Customer Reviews for Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha (4)
Customer Images
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Application: In vitro bioactivity in cell cultureVerified Customer | Posted 01/13/2020
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Application: In vitro bioactivity in cell cultureVerified Customer | Posted 05/27/2019
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Application: Receptor activation by CXCL12 Ligand to screen for NFKB pathway activation by Western Blot: Treat MDA231 cells with CXCL12 to look into whether CXCR4 activation by CXCL12 induced NFkB activation by phosphorylating IkBa by Western BlotReason for Rating: Receptor activation by CXCL12 Ligand to screen for NFKB pathway activation by Western Blot: Treat MDA231 cells with CXCL12 to look into whether CXCR4 activation by CXCL12 induced NFkB activation by phosphorylating IkBa by Western BlotVerified Customer | Posted 03/13/2019
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Application: Cell migration/motilityVerified Customer | Posted 08/09/2016
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FAQs for Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha
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Does Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha Protein (Catalog # 350-NS or Catalog # 350-NS/CF) contain any tags?
Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha Protein (Catalog # 350-NS or Catalog # 350-NS/CF) does not contain any tags. Please refer to the Source section on the product-specific page for sequence information.