Why do some of R&D Systems proteins require reconstitution in an acidic buffer? Will this buffer hurt the cells?

Proteins should always be reconstituted and stored with the buffer recommended on the datasheet. Some proteins are extremely hydrophobic at neutral pH. If the suggested buffer is not used to reconstitute these proteins, they do not go fully into solution and much of the material may cling to the sides of the vial. When the protein is used for an assay, it can be diluted to working concentration with media or another suitable buffer which will neutralize the small amount of acid and make it safe to use with live cells.

Can Recombinant Human IL-2 Protein (Catalog # 202-IL) be reconstituted in PBS or water?

Recombinant Human IL-2 Protein (202-IL and 202-IL/CF) needs to be reconstituted to 100 μg/mL in sterile 100 mM Acetic Acid. Stability testing has been evaluated on the protein with these reconstitution conditions; we can guarantee performance under these reconstitution conditions. When the protein is diluted with the cell culture media or buffers to the working concentration, the concentration of the acid should be buffered or negligible.

Recombinant Human IL-2 Protein

Name: Recombinant Human IL-2 Protein
Brand: R&D Systems
SKU: 202-IL
Rating: 5 (1 reviews)

R&D Systems, Inc. a Bio-Techne Brand

Catalog # 202-IL

Citations (353)

(1)

Product Datasheet / COA / SDS

NEW Next Generation Products! Please try our NEW version of Human Recombinant IL-2 (BT-002). Combining R&D Systems quality with scalability that allows for lower price points and a solid supply chain.

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Setting the standard in quality research reagents

Key Product Details

Source:	E. coli
Accession #:	P60568
Applications:	Bioactivity

View Full Technical Details for Recombinant Human IL-2 Protein

Product Specifications for Recombinant Human IL-2 Protein

Source	E. coli-derived human IL-2 protein Ala21-Thr153, with an N-terminal Met
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin level	<0.10 EU per 1 μg of the protein by the LAL method.
N-terminal sequence Analysis	Met
Predicted Molecular Mass	15 kDa
SDS-PAGE	13 kDa, under reducing conditions.
Activity	Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. Gearing, A.J.H. and C.B. Bird (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 295. The ED₅₀ for this effect is 0.0500-0.250 ng/mL.

Scientific Data Examples for Recombinant Human IL-2 Protein

	Recombinant Human IL-2 Protein Bioactivity Recombinant Human IL-2 (Catalog # 202-IL) stimulates cell proliferation of the CTLL‑2 mouse cytotoxic T cell line. The ED₅₀ for this effect is 0.0500-0.250 ng/mL.
	Recombinant Human IL-2 Protein Bioactivity Comparison As an alternative, please consider our next generation Recombinant Human IL-2 (BT-002). It has equivalent bioactivity to Recombinant Human IL-2 (Catalog # 202-IL). It combines R&D Systems quality with scalability that allows for a solid supply chain. Both Recombinant Human IL-2 proteins are measured in a cell proliferation assay using CTLL 2 mouse cytotoxic T cells.
	Equivalent Bioactivity of GMP, Animal-Free, and RUO grades of Recombinant Human IL-2 Equivalent bioactivity of GMP (202-GMP), Animal-Free (AFL202) and RUO (Catalog # 202-IL) grades of Recombinant Human IL-2 as measured in a cell proliferation assay CTLL 2 mouse cytotoxic T cells (orange, green, red, respectively).
	Recombinant Human IL-2 Protein SDS-PAGE 1 μg/lane of Recombinant Human IL-2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 13 kDa.

Formulation, Preparation and Storage

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

202-IL

Carrier

Formulation	Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution	Reconstitute at 100 μg/mL in sterile 100 mM Acetic Acid containing at least 0.1% human or bovine serum albumin. Alternatively, reconstitute at 100 μg/mL in sterile deionized water and use within 24 hours, store at 2 to 8 °C.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

202-IL/CF

Carrier Free

Formulation	Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution	Reconstitute at 100 μg/mL in sterile 100 mM Acetic Acid. Alternatively, reconstitute at 100 μg/mL in sterile deionized water and use within 24 hours, store at 2 to 8 °C.
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-2

Recombinant Interleukin-2 (IL-2) is expressed in E. coli and has been engineered to contain the serine for cysteine substitution found in Proleukin^® (aldesleukin). Recombinant IL-2 is widely used in cell culture for the expansion of T cells. IL-2 is expressed by CD4+ and CD8+ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils (1-3). Mature human IL-2 shares 56% and 66% amino acid (aa) sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit cross-species activity (4). The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes (5-7). The 55 kDa IL-2 R alpha is specific for IL-2 and binds with low affinity. The 75 kDa IL-2 R beta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. The 64 kDa common gamma chain gamma c/IL-2 R gamma, which is shared with the receptors for IL-4, -7, -9, -15, and -21, does not independently interact with IL-2. Upon ligand binding, signal transduction is performed by both IL-2 R beta and gamma c.

IL-2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to proliferate and induces IL-2 and IL-2 R alpha synthesis (1, 2). It contributes to T cell homeostasis by promoting the Fas-induced death of naïve CD4+ T cells but not activated CD4+ memory lymphocytes (8). IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells (9-11). Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity (12, 13).

IL-2 expression and concentration can have either immunostimulatory effects at high doses or immunosuppressive effects at low doses due to its preferential binding to different receptor subunits expressed by various immune cell types. This has led to the generation of recombinant IL-2 variants aimed at modifying IL-2 receptor binding for increased antitumor efficacy (14, 15). These variants are typically used in combination with immune checkpoint inhibitors instead of as a monotherapy (14). IL-2 can be genetically engineered to express in NK cells for CAR T cell therapies, and in combination with other cytokines like IL-15, can increase cell viability and proliferation (16). In addition to adoptive cell transfer and checkpoint blockade inhibitors, cancer vaccines that boost immune responses have been combined with IL-2 treatment with promising results in recent studies (15).

In cell culture, IL-2 is a frequently used cytokine for the proliferation, differentiation, and increased antibody secretion of B cells as they transform into plasma cells in vitro (17). IL-2 is also a classically used cytokine for the expansion of NK cells, early differentiated T cells and effector memory Treg cells for adoptive cell transfer cancer immunotherapy (16, 18). GMP IL-2 is a commonly used supplement for the expansion of these cell types for cellular therapies.

Item	Value
References	Ma, A. et al. (2006) Annu. Rev. Immunol. 24:657. Gaffen, S.L. and K.D. Liu (2004) Cytokine 28:109. Taniguchi, T. et al. (1983) Nature 302:305. Mosmann, T.R. et al. (1987) J. Immunol. 138:1813. Liparoto, S.F. et al. (2002) Biochemistry 41:2543. Wang, X. et al. (2005) Science 310:1159. Bodnar, A. et al. (2008) Immunol. Lett. 116:117. Jaleco, S. et al. (2003) J. Immunol. 171:61. Malek, T.R. (2003) J. Leukoc. Biol. 74:961. Laurence, A. et al. (2007) Immunity 26:371. Kryczek, I. et al. (2007) J. Immunol. 178:6730. Afzali, B. et al. (2007) Clin. Exp. Immunol. 148:32. Fehervari, Z.et al. (2006) Trends Immunol. 27:109. Xue, D. et al. (2021) Antibody Therapeutics. 4(2): 123-133. Wolfarth, A.A. et al. (2022) Immune Netw. 22(1): e5. Koehl, U. et al. (2015) Oncoimmunology. 5(4). Marsman, C. et al. (2022) Front. In Immunol. 13(815449). Chamucero-Millares, J.A. et al. (2021) Cellular Immunology. 360(104257).
Long Name	Interleukin 2
Entrez Gene IDs	3558 (Human); 16183 (Mouse); 116562 (Rat); 396868 (Porcine); 280822 (Bovine); 403989 (Canine); 100034204 (Equine); 751114 (Feline); 100302458 (Rabbit)
Alternate Names	Aldesleukin, IL-2, IL-2lymphokine, IL2, Proleukin, T cell growth factor, T-cell growth factor, TCGF, interleukin 2, interleukin-2, involved in regulation of T-cell clonal expansion

Citations for Recombinant Human IL-2 Protein (353)

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Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human IL-2 Protein include:

Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ACH Szeto et al. (2023), An alphavbeta3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity Nature Immunology, 24(1):123-135.
PMID: 36550322
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

G Silva et al. (2023), Novel scFv against Notch Ligand JAG1 Suitable for Development of Cell Therapies toward JAG1-Positive Tumors Biomolecules, 13(3).
PMID: 36979394
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CA Robinson et al. (2022), Novel Compound Inhibitors of HIV-1NL4-3 Vpu Viruses, 14(4).
PMID: 35458546
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

P Lopez et al. (2022), T cell migration potentiates HIV infection by enhancing viral fusion and integration Cell Reports, 38(8):110406.
PMID: 35196491
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

G Rodionov et al. (2022), Short treatment of peripheral blood cells product with Fas ligand using closed automated cell processing system significantly reduces immune cell reactivity of the graft in vitro and in vivo Bone marrow transplantation, 0(0).
PMID: 35538142
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

B Noailly et al. (2022), Antiviral Activities of HIV-1-Specific Human Broadly Neutralizing Antibodies Are Isotype-Dependent Vaccines, 10(6).
PMID: 35746511
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

WE Jiao et al. (2022), Notch2-dependent GATA3+ Treg cells alleviate allergic rhinitis by suppressing the Th2 cell response International immunopharmacology, 112(0):109261.
PMID: 36155282
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Cruz-Loren et al. (2022), Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity Viruses, 14(10).
PMID: 36298843
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

MJ Lee et al. (2022), SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D Cell Reports, 41(13):111892.
PMID: 36543165
Species: Complex Species Category
Sample Types: Cell Culture Supernates
Applications: Bioassay

R Boytz et al. (2022), Inactivation of Ebola Virus and SARS-CoV-2 in Cell Culture Supernatants and Cell Pellets by Gamma Irradiation Viruses, 15(1).
PMID: 36680083
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

KO Jang et al. (2021), Complement Inactivation Strategy of Staphylococcus aureus Using Decay-Accelerating Factor and the Response of Infected HaCaT Cells International Journal of Molecular Sciences, 22(8).
PMID: 33924622
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AM Farhat et al. (2021), Modeling cell-specific dynamics and regulation of the common gamma chain cytokines Cell Reports, 35(4):109044.
PMID: 33910015
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MN Theodoraki et al. (2021), Changes in circulating exosome molecular profiles following surgery/(chemo)radiotherapy: early detection of response in head and neck cancer patients British Journal of Cancer, 0(0).
PMID: 34642463
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Yu et al. (2021), Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2pos subjects Cell Research, 0(0).
PMID: 34561618
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Dai et al. (2021), Elevated beta-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer's disease Brain, Behavior, and Immunity, 98(0):337-348.
PMID: 34500034
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AT Tan et al. (2021), Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients Cell Reports, 34(6):108728.
PMID: 33516277
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JH Ruth et al. (2021), CD6 is a target for cancer immunotherapy JCI Insight, 0(0).
PMID: 33497367
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SA Saenz et al. (2021), Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo PLoS ONE, 16(11):e0248034.
PMID: 34752458
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

P Prakhar et al. (2021), The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function JCI Insight, 6(21).
PMID: 34747370
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CH Kang et al. (2021), c-Met-Specific Chimeric Antigen Receptor T Cells Demonstrate Anti-Tumor Effect in c-Met Positive Gastric Cancer Cancers, 13(22).
PMID: 34830894
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ED Rossignol et al. (2021), Mining HIV controllers for broad and functional antibodies to recognize and eliminate HIV-infected cells Cell Reports, 35(8):109167.
PMID: 34038720
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Deng et al. (2021), Anaphylatoxins orchestrate Th17 response via interactions between CD16+ monocytes and pleural mesothelial cells in tuberculous pleural effusion PloS Neglected Tropical Diseases, 15(7):e0009508.
PMID: 34237073
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HL Penny et al. (2021), Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma International Journal of Molecular Sciences, 22(12).
PMID: 34198548
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

A Mauriello et al. (2020), Immunological effects of adjuvants in subsets of antigen presenting cells of cancer patients undergoing chemotherapy J Transl Med, 18(1):34.
PMID: 31973714
Species: Mouse
Sample Types: Whole Cell
Applications: Cell Culture

JB McBrien et al. (2020), Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells Nature, 0(0).
PMID: 31969705
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

J Brzostek et al. (2020), T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis Nat. Immunol., 0(0).
PMID: 31932808
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

D Gate et al. (2020), Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease Nature, 577(7790):399-404.
PMID: 31915375
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Y Wan et al. (2020), Hyperfunction of CD4 CD25 regulatory T cells in de novo acute myeloid leukemia BMC Cancer, 20(1):472.
PMID: 32456622
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Froning et al. (2020), Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics Nat Commun, 11(1):2330.
PMID: 32393818
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

W Gao et al. (2020), NADPH oxidase 5&alpha promotes the formation of CD271 tumor-initiating cells in oral cancer Am J Cancer Res, 10(6):1710-1727.
PMID: 32642285
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

IJ Beccard et al. (2020), Immune Suppressive Effects of Plasma-Derived Exosome Populations in Head and Neck Cancer Cancers (Basel), 12(7).
PMID: 32708274
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

T Chirkova et al. (2020), In vitro model for the assessment of human immune responses to subunit RSV vaccines PLoS ONE, 15(3):e0229660.
PMID: 32191728
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Y Gong et al. (2020), Novel elvitegravir nanoformulation for drug delivery across the blood-brain barrier to achieve HIV-1 suppression in the CNS macrophages Sci Rep, 10(1):3835.
PMID: 32123217
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

R Fonseca et al. (2020), Developmental plasticity allows outside-in immune responses by resident memory T cells Nat. Immunol., 0(0).
PMID: 32066954
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

S Zicari et al. (2020), DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR Oncotarget, 11(7):699-726.
PMID: 32133046
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Y Hu et al. (2020), Targeting of CD38 by the tumor suppressor miR-26a serves as a novel potential therapeutic agent in multiple myeloma Cancer Res., 0(0).
PMID: 32193289
Species: Mouse
Sample Types: Dendritic Cells
Applications: Bioassay

AE Morelli et al. (2020), Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells Cell Rep, 30(10):3448-3465.e8.
PMID: 32160549
Species: Human
Sample Types: Leukocytes
Applications: Bioassay

J Lubow et al. (2020), Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages Elife, 9(0).
PMID: 32119644
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

M Bachsais et al. (2020), CD154 inhibits death of T cells via a Cis interaction with the &alpha5&beta1 integrin PLoS ONE, 15(8):e0235753.
PMID: 32745080
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

SV Radhakrish et al. (2020), CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide Nat Commun, 11(1):798.
PMID: 32034142
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

BMF Winkel et al. (2020), Plasmodium sporozoites induce regulatory macrophages PLoS Pathog., 16(9):e1008799.
PMID: 32898164
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

O Bartok et al. (2020), Anti-tumour immunity induces aberrant peptide presentation in melanoma Nature, 0(0).
PMID: 33328638
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KK Naidoo et al. (2020), The DARC-null trait is associated with moderate modulation of NK cell profiles and unaltered cytolytic T cell profiles in black South Africans PLoS ONE, 15(11):e0242448.
PMID: 33211774
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

MW Grunst et al. (2020), Functional Interactions of Common Allotypes of Rhesus Macaque Fc&gammaR2A and Fc&gammaR3A with Human and Macaque IgG Subclasses J Immunol, 0(0).
PMID: 33208458
Species: Human
Sample Types: Cells
Applications: Cell Culture

T Petrova et al. (2020), p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells Sci Rep, 10(1):3479.
PMID: 32103032
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Z Zi et al. (2020), B7-H3 Chimeric Antigen Receptor Redirected T Cells Target Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma Cancers, 12(12).
PMID: 33348781
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

S Campinoti et al. (2020), Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Nature Communications, 11(1):6372.
PMID: 33311516
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

PJ Metz et al. (2020), Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling Cell Rep, 30(6):1935-1950.e8.
PMID: 32049022
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Yan et al. (2020), T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Cell Rep, 31(13):107820.
PMID: 32610123
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Gong et al. (2020), An Elvitegravir Nanoformulation Crosses the Blood-Brain Barrier and Suppresses HIV-1 Replication in Microglia Viruses, 12(5).
PMID: 32443728
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SL Bevington et al. (2020), Chromatin Priming Renders T Cell Tolerance-Associated Genes Sensitive to Activation below theï¿½Signaling Threshold for Immune Response Genes Cell Rep, 31(10):107748.
PMID: 32521273
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Dharan et al. (2020), Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus Nat Microbiol, 0(0).
PMID: 32483230
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Z Li et al. (2020), Identification of unrecognized host factors promoting HIV-1 latency PloS Pathogens, 16(12):e1009055.
PMID: 33270809
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

C Schleiss et al. (2019), BCR-associated factors driving chronic lymphocytic leukemia cells proliferation ex vivo Sci Rep, 9(1):701.
PMID: 30679590
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Zhao et al. (2019), Indirubin modulates CD4+ T-cell homeostasis via PD1/PTEN/AKT signalling pathway in immune thrombocytopenia J. Cell. Mol. Med., 0(0).
PMID: 30609280
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Zhang et al. (2019), SA-49, a novel aloperine derivative, induces MITF-dependent lysosomal degradation of PD-L1 EBioMedicine, 0(0).
PMID: 30711516
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

W Xu et al. (2019), Mapping of ?/? T cells reveals V?2+ T cells resistance to senescence EBioMedicine, 39(0):44-58.
PMID: 30528453
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MH Abumaree et al. (2019), Preconditioning human natural killer cells with chorionic villous mesenchymal stem cells stimulates their expression of inflammatory and anti-tumor molecules Stem Cell Res Ther, 10(1):50.
PMID: 30728068
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

X Ma et al. (2019), TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb Elife, 8(0).
PMID: 30652970
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Herviou et al. (2019), EZH2 is overexpressed in transitional preplasmablasts and is involved in human plasma cell differentiation Leukemia, 0(0).
PMID: 30755708
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Fourati et al. (2019), Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine Nat Commun, 10(1):863.
PMID: 30787294
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Luo et al. (2019), Negligible Effect of Sodium Chloride on the Development and Function of TGF-?-Induced CD4+ Foxp3+ Regulatory T Cells Cell Rep, 26(7):1869-1879.e3.
PMID: 30759396
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Whelan et al. (2019), PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function Cancer Immunol Res, 0(0).
PMID: 30659054
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

DL Owen et al. (2019), Thymic regulatory T cells arise via two distinct developmental programs Nat. Immunol., 20(2):195-205.
PMID: 30643267
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Kong et al. (2019), Downregulation of CD73 associates with T cell exhaustion in AML patients J Hematol Oncol, 12(1):40.
PMID: 31014364
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

W Yang et al. (2019), Immunogenic neoantigens derived from gene fusions stimulate T cell responses Nat. Med., 0(0).
PMID: 31011208
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

I Lorthois et al. (2019), Infiltration of T Cells into a Three-Dimensional Psoriatic Skin Model Mimics Pathological Key Features Int J Mol Sci, 20(7).
PMID: 30987186
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Farina et al. (2019), HLA-DQA1 and HLA-DQB1 Alleles, Conferring Susceptibility to Celiac Disease and Type 1 Diabetes, are More Expressed Than Non-Predisposing Alleles and are Coordinately Regulated Cells, 8(7).
PMID: 31331105
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Gras Navar et al. (2019), Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival Cancers (Basel), 11(7).
PMID: 31319548
Species: Human
Sample Types: Organoid
Applications: Bioassay

KB Jung et al. (2019), Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells J Clin Med, 8(7).
PMID: 31277507
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

K Kurihara et al. (2019), Significance of IL-17A-producing CD8+CD103+ skin resident memory T cells in psoriasis lesion and their possible relationship to clinical course J. Dermatol. Sci., 95(1):21-27.
PMID: 31300254
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AK Holbrook et al. (2019), CD4+ T cell activation and associated susceptibility to HIV-1 infection in vitro increased following acute resistance exercise in human subjects Physiol Rep, 7(18):e14234.
PMID: 31552706
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Lv et al. (2019), MicroRNA?155 inhibits the proliferation of CD8+ Tï¿½cells via upregulating regulatory T cells in vitiligo Mol Med Rep, 20(4):3617-3624.
PMID: 31485649
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Vitale et al. (2019), The intestinal expansion of TCRÎ³Î´+ and disappearance of IL4+ T cells suggest their involvement in the evolution from potential to overt celiac disease Eur. J. Immunol., 0(0).
PMID: 31553811
Species: Human
Sample Types: Whole Cells
Applications: CAR-T (Bioassay)

F Zou et al. (2019), Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56 Nat Commun, 10(1):4109.
PMID: 31511513
Species: Human
Sample Types: Organoid
Applications: Bioassay

KB Jung et al. (2019), Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells J Clin Med, 8(7).
PMID: 31277507
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MW LaFleur et al. (2019), PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity Nat. Immunol., 20(10):1335-1347.
PMID: 31527834
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Q Zheng et al. (2019), Internal Ribosome Entry Site Dramatically Reduces Transgene Expression in Hematopoietic Cells in a Position-Dependent Manner Viruses, 11(10).
PMID: 31597367
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

P Tuijnenbur et al. (2019), High-throughput compound screen reveals mTOR inhibitors as potential therapeutics to reduce (auto)antibody production by human plasma cells Eur. J. Immunol., 0(0).
PMID: 31621069
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Caccuri et al. (2019), The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3) Int J Mol Sci, 20(21).
PMID: 31653015
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

AP Bénéchet et al. (2019), Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming Nature, 0(0).
PMID: 31582858
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JJ Montoya et al. (2019), In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells BMC Cancer, 19(1):1251.
PMID: 31881855
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N An et al. (2019), The prognostic role of circulating CD8+ T cell proliferation in patients with untreated extensive stage small cell lung cancer J Transl Med, 17(1):402.
PMID: 31796037
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

X Huan et al. (2019), Crystal structure of suboptimal viral fragments of Epstein Barr Virus Rta peptide-HLA complex that stimulate CD8 T cell response Sci Rep, 9(1):16660.
PMID: 31723204
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ER Wonderlich et al. (2019), Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals PLoS Pathog., 15(10):e1008074.
PMID: 31609991
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

A Koenig et al. (2019), Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants Nat Commun, 10(1):5350.
PMID: 31767837
Species: Human
Sample Types: Whole Cell
Applications: Cell Culture

M Yamagishi et al. (2019), Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas Cell Rep, 29(8):2321-2337.e7.
PMID: 31747604
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

JC Ravell et al. (2019), Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease J. Clin. Invest., 0(0).
PMID: 31714901
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

C Quintarell et al. (2019), Efficacy of third-party chimeric antigen receptor modified peripheral blood natural killer cells for adoptive cell therapy of B-cell precursor acute lymphoblastic leukemia Leukemia, 0(0).
PMID: 31745215
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Castillo et al. (2019), CBP/p300 drives the differentiation of Regulatory T cells through transcriptional and non-transcriptional mechanisms Cancer Res., 0(0).
PMID: 31182547
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

KW Kalim et al. (2018), Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42 J. Immunol., 0(0).
PMID: 29440353
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Nagel et al. (2018), Aberrant expression of NKL homeobox gene HLX in Hodgkin lymphoma Oncotarget, 9(18):14338-14353.
PMID: 29581848
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

D Wang et al. (2018), Efficacy of intracellular immune checkpoint-silenced DC vaccine JCI Insight, 3(3).
PMID: 29415891
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

C Engdahl et al. (2018), Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women Arthritis Res. Ther., 20(1):84.
PMID: 29720252
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JR Podojil et al. (2018), ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance J. Immunol., 0(0).
PMID: 29431690
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Pei et al. (2018), Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis Sci Rep, 8(1):5273.
PMID: 29588471
Species: Feline
Sample Types: Whole Cells
Applications: Bioassay

M Nag et al. (2018), Histone Modulation Blocks Treg-Induced Foxp3 Binding to the IL-2 Promoter of Virus-Specific CD8? T Cells from Feline Immunodeficiency Virus-Infected Cats Viruses, 10(6).
PMID: 29861472
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Stamm et al. (2018), Immune checkpoints PVR and PVRL2 are prognostic markers in AML and their blockade represents a new therapeutic option Oncogene, 0(0).
PMID: 29855615
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Schmidt et al. (2018), Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3 BMC Biol., 16(1):47.
PMID: 29730990
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Kim et al. (2018), Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer PLoS ONE, 13(6):e0198347.
PMID: 29874279
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y He et al. (2018), Multiple Antigen Stimulating Cellular Therapy (MASCT) For Hepatocellular Carcinoma After Curative Treatment: A Retrospective Study J Cancer, 9(8):1385-1393.
PMID: 29721048
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

PO Flores-Vil et al. (2018), An Isolated TCR ?? Restricted by HLA-A*02:01/CT37 Peptide Redirecting CD8+T Cells To Kill and Secrete IFN-? in Response to Lung Adenocarcinoma Cell Lines J. Immunol., 0(0).
PMID: 29555781
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MH Abumaree et al. (2018), Characterization of the interaction between human decidua parietalis mesenchymal stem/stromal cells and natural killer cells Stem Cell Res Ther, 9(1):102.
PMID: 29650045
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Ren et al. (2018), Similarity and difference in tumor-infiltrating lymphocytes in original tumor tissues and those ofexpanded populations in head and neck cancer Oncotarget, 9(3):3805-3814.
PMID: 29423084
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Tanaka et al. (2018), KAP1 Regulates Regulatory T Cell Function and Proliferation in Both Foxp3-Dependent and -Independent Manners Cell Rep, 23(3):796-807.
PMID: 29669285
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

X Chen et al. (2018), Interleukin 35: Inhibitory regulator in monocyte-derived dendritic cell maturation and activation Cytokine, 108(0):43-52.
PMID: 29571039
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CY Kuo et al. (2018), Site-Specific Gene Editing of Human Hematopoietic Stem Cells for X-Linked Hyper-IgM Syndrome Cell Rep, 23(9):2606-2616.
PMID: 29847792
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

X Zhao et al. (2018), Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling Nat Commun, 9(1):2716.
PMID: 30006605
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

C You et al. (2018), Imperatorin Targets MCL-1 to Sensitize CD133+ Lung Cancer Cells to ??-T Cell-Mediated Cytotoxicity Cell. Physiol. Biochem., 49(1):235-244.
PMID: 30138935
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SR Kim et al. (2018), BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition Oncotarget, 9(49):29193-29207.
PMID: 30018745
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay

S Krishna et al. (2018), Human papilloma virus specific immunogenicity and dysfunction of CD8+ T cells in head and neck cancer Cancer Res., 0(0).
PMID: 30154146
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Guo et al. (2018), D-Mannose Enhanced Immunomodulation of Periodontal Ligament Stem Cells via Inhibiting IL-6 Secretion Stem Cells Int, 2018(0):7168231.
PMID: 30271438
Species: Mouse
Sample Types: Whole Cells
Applications: CAR-T (Differentiation)

S Viaud et al. (2018), Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 30373813
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AA Throm et al. (2018), Dysregulated NK cell PLC?2 signaling and activity in juvenile dermatomyositis JCI Insight, 3(22).
PMID: 30429375
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Li et al. (2018), Substrate-independent immunomodulatory characteristics of mesenchymal stem cells in three-dimensional culture PLoS ONE, 13(11):e0206811.
PMID: 30408051
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Zhu et al. (2018), Ring finger protein 31-mediated atypical ubiquitination stabilizes forkhead box P3 and thereby stimulates regulatory T-cell function J. Biol. Chem., 0(0).
PMID: 30389786
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MD Shortridge et al. (2018), An ultra-high affinity ligand of HIV-1 TAR reveals the RNA structure recognized by P-TEFb Nucleic Acids Res., 0(0).
PMID: 30481318
Species: Human
Sample Types: Whole Cells
Applications: CAR-T

Ghassemi S et al. (2018), Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells. Cancer Immunol Res, 6(9):1100-1109.
PMID: 30030295
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Najar et al. (2018), Mesenchymal stromal cells of the bone marrow and natural killer cells: cell interactions and cross modulation J Cell Commun Signal, 0(0).
PMID: 29350342
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Misra et al. (2018), Glycosyl-phosphatidylinositol-Anchored Anti-HIV Env Single Chain Variable Fragments Interfere with HIV-1 Env Processing and Viral Infectivity J. Virol., 0(0).
PMID: 29321330
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Zheng et al. (2018), Molecular transitions in early progenitors during human cord blood hematopoiesis Mol. Syst. Biol., 14(3):e8041.
PMID: 29545397
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MC Neidert et al. (2018), The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy Acta Neuropathol., 0(0).
PMID: 29557506
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Koh et al. (2018), Non-lytic Lymphocytes Engineered to Express Virus-specific T-cell Receptors Limit HBV Infection by Activating APOBEC3 Gastroenterology, 0(0).
PMID: 29550589
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

A Seki et al. (2018), Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells J. Exp. Med., 0(0).
PMID: 29436394
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Ilic et al. (2018), Trichinella spiralis Excretory-Secretory Products Induce Tolerogenic Properties in Human Dendritic CellsviaToll-Like Receptors 2 and 4 Front Immunol, 9(0):11.
PMID: 29416536
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Golden-Mas et al. (2018), Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment Hepatol Commun, 2(4):364-375.
PMID: 29619416
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

K Gamo et al. (2018), Gene Signature-Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNFÎ± Treatment for Crohn's Disease Inflamm. Bowel Dis., 0(0).
PMID: 29669006
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MM Shikhagaie et al. (2017), Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates Cell Rep, 18(7):1761-1773.
PMID: 28199847
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Sarmiento et al. (2017), Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy Sci Rep, 7(1):11077.
PMID: 28894116
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Leiber et al. (2017), Neonatal myeloid derived suppressor cells show reduced apoptosis and immunosuppressive activity upon infection with Escherichia coli Eur. J. Immunol., 0(0).
PMID: 28493377
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

VA Gall et al. (2017), Trastuzumab Increases HER2 Uptake and Cross-Presentation by Dendritic Cells Cancer Res., 0(0).
PMID: 28819024
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Barsheshet et al. (2017), CCR8(+)FOXp3(+) Treg cells as master drivers of immune regulation Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 28533380
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

PA Frischmeye et al. (2017), Mechanistic Correlates of Clinical Responses to Omalizumab in the Setting of Oral Immunotherapy for Milk Allergy J. Allergy Clin. Immunol., 0(0).
PMID: 28414061
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Galland et al. (2017), Tumor-Derived Mesenchymal Stem Cells Use Distinct Mechanisms to Block the Activity of Natural Killer Cell Subsets Cell Rep, 20(12):2891-2905.
PMID: 28930684
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Mediavilla et al. (2017), A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment Neoplasia, 19(7):530-536.
PMID: 28582704
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Pichugin et al. (2017), The IGH locus relocalizes to a recombination compartment in the perinucleolar region of differentiating B-lymphocytes Oncotarget, 0(0).
PMID: 28445143
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Van Hout et al. (2017), Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors PLoS ONE, 12(4):e0176057.
PMID: 28410420
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Schoenhals et al. (2017), Hypoxia favors the generation of human plasma cells Cell Cycle, 0(0):1-14.
PMID: 28463531
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JL Platt et al. (2017), C3d regulates immune checkpoint blockade and enhances antitumor immunity JCI Insight, 2(9).
PMID: 28469081
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

C Tao et al. (2017), ??TCR immunoglobulin constant region domain exchange in human ??TCRs improves TCR pairing without altering TCR gene-modified T cell function Mol Med Rep, 0(0).
PMID: 28259946
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JE Hammonds et al. (2017), Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1 PLoS Pathog, 13(1):e1006181.
PMID: 28129379
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

X Li et al. (2017), Interleukin 2 and interleukin 10 function synergistically to promote CD8(+) T cell cytotoxicity, which is suppressed by regulatory T cells in breast cancer Int. J. Biochem. Cell Biol, 0(0).
PMID: 28274688
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Kawamura et al. (2017), Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells Sci Rep, 7(1):1659.
PMID: 28490810
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Lanna et al. (2017), A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging Nat. Immunol, 0(0).
PMID: 28114291
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Bagheri et al. (2017), Selection of single chain antibody fragments binding to the extracellular domain of 4-1BB receptor by phage display technology Tumour Biol, 39(3):1010428317695.
PMID: 28347235
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Tousa et al. (2017), Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses Proc. Natl. Acad. Sci. U.S.A, 0(0).
PMID: 28320933
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Pavesi et al. (2017), A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors JCI Insight, 2(12).
PMID: 28614795
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Köstlin et al. (2017), Granulocytic myeloid derived suppressor cells from human cord blood modulate T-helper-cell response towards an anti-inflammatory phenotype Immunology, 0(0).
PMID: 28464218
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Z Lu et al. (2017), Therapeutic immune monitoring of CD4(+)CD25(+) T cells in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors Oncol Lett, 14(2):1363-1372.
PMID: 28808483
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Ding et al. (2017), Ref-1/APE1 as Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia Mol. Cancer Ther., 0(0).
PMID: 28446640
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Xia et al. (2017), Negative regulation of tumor-infiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway Oncotarget, 8(23):37783-37795.
PMID: 28384121
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

DA Donahue et al. (2017), SUN2 silencing impairs CD4 T cell proliferation and alters sensitivity to HIV-1 infection independently of Cyclophilin A J. Virol, 0(0).
PMID: 28077629
Species: Chinchilla
Sample Types: Whole Cells
Applications: Bioassay

LA Novotny et al. (2017), Transcutaneous immunization with a bandaid prevents experimental otitis media in a polymicrobial model Clin. Vaccine Immunol., 0(0).
PMID: 28381402
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R Havunen et al. (2017), Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy Mol Ther Oncolytics, 4(0):77-86.
PMID: 28345026
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Netchiporo et al. (2017), Analysis of CTCL cell lines reveals important differences between mycosis fungoides/Sï¿½zary syndrome vs. HTLV-1+ leukemic cell lines Oncotarget, 8(56):95981-95998.
PMID: 29221181
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Takada et al. (2017), EBV induces persistent NF-?B activation and contributes to survival of EBV-positive neoplastic T- or NK-cells PLoS ONE, 12(3):e0174136.
PMID: 28346502
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

GJ Britton et al. (2017), PKC? links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton Elife, 6(0).
PMID: 28112644
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Nakayama et al. (2017), Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity J. Immunol., 199(7):2388-2407.
PMID: 28848067
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

U Bughani et al. (2017), T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab PLoS ONE, 12(7):e0180088.
PMID: 28672038
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Jourdan et al. (2017), Characterization of human FCRL4-positive B cells PLoS ONE, 12(6):e0179793.
PMID: 28636654
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

DL Bolton et al. (2017), Combined single-cell quantitation of host and SIV genes and proteins ex vivo reveals host-pathogen interactions in individual cells PLoS Pathog., 13(6):e1006445.
PMID: 28654687
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HG Hilton et al. (2017), The Intergenic Recombinant HLA-B?46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands Cell Rep, 19(7):1394-1405.
PMID: 28514659
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

DY Hu et al. (2017), IL-2 prevents deletion of developing T-regulatory cells in the thymus Cell Death Differ., 0(0).
PMID: 28362433
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Tovar-Sala et al. (2017), Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity PLoS ONE, 12(7):e0180691.
PMID: 28683106
Species: Human
Sample Types: Protein
Applications: Surface Plasmon Resonance

AP Vicari et al. (2017), Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis MAbs, 0(0):0.
PMID: 28581883
Species: Human
Sample Types: Whole Cells

A Camelo et al. (2017), IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells Blood Adv, 1(10):577-589.
PMID: 29296700
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Ke et al. (2016), SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice Oncotarget, 7(31):49509-49526.
PMID: 27385218
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency Proc. Natl. Acad. Sci. U.S.A, 0(0).
PMID: 27930337
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation Nat Commun, 7(0):11473.
PMID: 27145901
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Effects of Cigarette Smoke Condensate on Oxidative Stress, Apoptotic Cell Death, and HIV Replication in Human Monocytic Cells PLoS ONE, 11(5):e0155791.
PMID: 27203850
Species: Human
Sample Types: Cell Culture Supernates
Applications: Luminex Development

Supper V et al. (2016), Association of CD147 and Calcium Exporter PMCA4 Uncouples IL-2 Expression from Early TCR Signaling. J Immunol, 196(3):1387-99.
PMID: 26729804
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Tanaka et al. (2016), Development of engineered T cells expressing a chimeric CD16-CD3? receptor to improve the clinical efficacy of mogamulizumab therapy against adult T cell leukemia Clin Cancer Res, 0(0).
PMID: 27091408
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Yadollah Omidi (2016), Development of screen-printed tryptophan-kynurenine immunosensor for in vitro assay of kynurenine-mediated immunosuppression effect of cancer cells on activated T-cells Biosens Bioelectron, 0(0).
PMID: 27840038
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Fabrizio Antonangel (2016), Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells Oncoimmunology, 5(10):e1218105.
PMID: 27853638
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML Mol Ther Methods Clin Dev, 3(0):16074.
PMID: 27933304
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TM Garcia-Bat et al. (2016), Enhanced Cytotoxic CD8 T Cell Priming Using Dendritic Cell-Expressing Human Papillomavirus-16 E6/E7-p16INK4 Fusion Protein with Sequenced Anti-Programmed Death-1 J. Immunol, 196(6):2870-8.
PMID: 26851223
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Jun Li (2016), Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation Nat Commun, 7(0):11730.
PMID: 27291871
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

L J Spicer (2016), G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications Domest. Anim. Endocrinol, 59(0):90-99.
PMID: 28040605
Species: Bat - Pteropus alecto
Sample Types: Whole Cells
Applications: Bioassay

(2016), Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages Sci Rep, 6(0):38597.
PMID: 27934903
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Functional differences in hepatitis C virus nonstructural (NS) 3/4A- and 5A-specific T cell responses Sci Rep, 6(0):24991.
PMID: 27141891
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RB Jones et al. (2016), A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes PLoS Pathog, 12(4):e1005545.
PMID: 27082643
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Liu et al. (2016), The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1 J. Virol., 90(23):10642-10659.
PMID: 27654286
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ivan Carcamo-Or (2016), Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity Cell Stem Cell, 0(0).
PMID: 28017796
Species: Human
Sample Types: Plasma
Applications: Bioassay

(2016), Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status Circ Res, 0(0).
PMID: 27418629
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

James B Canavan (2016), Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease Gut, 65(4):584-94.
PMID: 25715355
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kostlin N et al. (2016), Granulocytic Myeloid-Derived Suppressor Cells Accumulate in Human Placenta and Polarize toward a Th2 Phenotype. J Immunol, 196(3):1132-45.
PMID: 26712947
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016), Native cellulose nanofibrills induce immune tolerance in vitro by acting on dendritic cells Sci Rep, 6(0):31618.
PMID: 27558765
Species: Human
Sample Types: Whole Cells
Applications: CAR-T (Bioassay)

Rodgers D et al. (2016), Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies. Proc Natl Acad Sci U S A, 113(4):E459-68.
PMID: 26759369
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Capuano C et al. (2015), Anti-CD20 Therapy Acts via FcgammaRIIIA to Diminish Responsiveness of Human Natural Killer Cells. Cancer Res, 75(19):4097-108.
PMID: 26229120
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Odorizzi P et al. (2015), Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells. J Exp Med, 212(7):1125-37.
PMID: 26034050
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fujiwara H et al. (2015), Antileukemia multifunctionality of CD4(+) T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer. Leukemia, 29(12):2393-401.
PMID: 26104661
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ahn Y et al. (2015), Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation. Eur J Immunol, 45(8):2335-42.
PMID: 26046454
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Broos C et al. (2015), Impaired survival of regulatory T cells in pulmonary sarcoidosis. Respir Res, 16(0):108.
PMID: 26376720
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nguyen L et al. (2015), Role and species-specific expression of colon T cell homing receptor GPR15 in colitis. Nat Immunol, 16(2):207-13.
PMID: 25531831
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tian X et al. (2015), The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects. J Immunol, 194(8):3873-82.
PMID: 25780040
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hill E et al. (2015), Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Eur J Immunol, 45(4):1103-15.
PMID: 25627813
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ling Y et al. (2015), Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. J Exp Med, 212(5):619-31.
PMID: 25918342
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hoffmann F et al. (2015), The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity. J Immunol, 194(2):542-52.
PMID: 25505277
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cerino A et al. (2015), A Human Monoclonal Antibody against Hepatitis B Surface Antigen with Potent Neutralizing Activity. PLoS ONE, 10(4):e0125704.
PMID: 25923526
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Li Y et al. (2015), Hair regrowth in alopecia areata patients following Stem Cell Educator therapy. BMC Med, 13(0):87.
PMID: 25896390
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ranzani et al. (2015), The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4. Nat Immunol, 16(3):318-25.
PMID: 25621826
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chai S et al. (2015), Identification of Four-Jointed Box 1 (FJX1)-Specific Peptides for Immunotherapy of Nasopharyngeal Carcinoma. PLoS ONE, 10(11):e0130464.
PMID: 26536470
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Berlin C et al. (2015), Mapping the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy. Leukemia, 29(3):647-59.
PMID: 25092142
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sumption N et al. (2015), Alpha-Particle-Induced Complex Chromosome Exchanges Transmitted through Extra-Thymic Lymphopoiesis In Vitro Show Evidence of Emerging Genomic Instability. PLoS ONE, 10(8):e0134046.
PMID: 26252014
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zingoni A et al. (2015), Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells. J Immunol, 195(2):736-48.
PMID: 26071561
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lam et al. (2015), Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy. Mol Ther, 23(2):387-95.
PMID: 25366030
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Yan J et al. (2015), CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain. J Biol Chem, 290(21):13279-92.
PMID: 25847232
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Goedken E et al. (2015), Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol. J Biol Chem, 290(8):4573-89.
PMID: 25552479
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zuo J et al. (2015), Increased CD160 expression on circulating natural killer cells in atherogenesis. J Transl Med, 13(0):188.
PMID: 26071079
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Huss et al. (2015), In vivo maintenance of human regulatory T cells during CD25 blockade. J Immunol, 194(1):84-92.
PMID: 25416807
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2015), Mature cytotoxic CD56(bright)/CD16(+) natural killer cells can infiltrate lymph nodes adjacent to metastatic melanoma. Cancer Res, 74(0):81.
PMID: 24225017
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pery E et al. (2015), Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein. J Biol Chem, 290(16):10504-17.
PMID: 25724652
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chien W et al. (2015), Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines. Sci Rep, 5(0):8068.
PMID: 25626693
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mohnle P et al. (2015), MicroRNA-146a controls Th1-cell differentiation of human CD4+ T lymphocytes by targeting PRKCepsilon. Eur J Immunol, 45(1):260-72.
PMID: 25308712
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Verhagen J et al. (2014), Ctla-4 modulates the differentiation of inducible Foxp3+ Treg cells but IL-10 mediates their function in experimental autoimmune encephalomyelitis. PLoS ONE, 9(9):e108023.
PMID: 25238105
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rieber N et al. (2014), Extracorporeal photopheresis increases neutrophilic myeloid-derived suppressor cells in patients with GvHD. Bone Marrow Transplant, 49(4):545-52.
PMID: 24464140
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Choudhuri K et al. (2014), Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse. Nature, 507(7490):118-23.
PMID: 24487619
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rebhandl S et al. (2014), Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia. Eur J Immunol, 44(7):2175-87.
PMID: 24668151
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kostlin N et al. (2014), Granulocytic myeloid derived suppressor cells expand in human pregnancy and modulate T-cell responses. Eur J Immunol, 44(9):2582-91.
PMID: 24894988
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lanna et al. (2014), The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Nat Immunol, 15(10):965-72.
PMID: 25151490
Forster F et al. (2014), Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton. J Immunol, 192(2):771-81.
PMID: 24337748
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kurktschiev P et al. (2014), Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction. J Exp Med, 211(10):2047-59.
PMID: 25225458
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Geyeregger R et al. (2014), Human AdV-specific T cells: persisting in vitro functionality despite lethal irradiation. Bone Marrow Transplant, 49(7):934-41.
PMID: 24777182
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Herr F et al. (2014), IL-2 phosphorylates STAT5 to drive IFN-gamma production and activation of human dendritic cells. J Immunol, 192(12):5660-70.
PMID: 24829413
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lebailly B et al. (2014), Linking the circadian rhythm gene Arntl2 to interleukin 21 expression in type 1 diabetes. Diabetes, 63(6):2148-57.
PMID: 24520124
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Leen A et al. (2014), Reversal of tumor immune inhibition using a chimeric cytokine receptor. Mol Ther, 22(6):1211-20.
PMID: 24732709
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Boswell K et al. (2014), Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection. PLoS Pathog, 10(1):e1003853.
PMID: 24497824
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wu L et al. (2014), The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling. J Immunol, 193(4):1590-9.
PMID: 25024377
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Ilett E et al. (2014), Cytokine conditioning enhances systemic delivery and therapy of an oncolytic virus. Mol Ther, 22(10):1851-63.
PMID: 24957982
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ashino S et al. (2014), Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses. J Allergy Clin Immunol, 133(4):1162-74.
PMID: 24365136
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mao C et al. (2014), Tumor-activated TCRgammadelta(+) T cells from gastric cancer patients induce the antitumor immune response of TCRalphabeta(+) T cells via their antigen-presenting cell-like effects. J Immunol Res, 2014(0):593562.
PMID: 24741609
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kumari S et al. (2014), Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes. Proc Natl Acad Sci U S A, 111(1):403-8.
PMID: 24344295
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tong Q et al. (2014), Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice. J Immunol, 192(11):5012-22.
PMID: 24760151
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kim et al. (2014), Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells. J Transl Med, 12(0):113.
PMID: 24885155
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhou H et al. (2014), Differential IL-10 production by DCs determines the distinct adjuvant effects of LPS and PTX in EAE induction. Eur J Immunol, 44(5):1352-62.
PMID: 24496948
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kofler D et al. (2014), Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest, 124(6):2513-22.
PMID: 24812667
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Molfetta R et al. (2014), c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells. Eur J Immunol, 44(9):2761-70.
PMID: 24846123
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

Michaux A et al. (2014), A spliced antigenic peptide comprising a single spliced amino acid is produced in the proteasome by reverse splicing of a longer peptide fragment followed by trimming. J Immunol, 192(4):1962-71.
PMID: 24453253
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ren Z et al. (2014), E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-kappaB modulation. Mol Cancer, 13(0):84.
PMID: 24742333
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

McCutcheon et al. (2014), Multiplexed screening of natural humoral immunity identifies antibodies at fine specificity for complex and dynamic viral targets. MAbs, 6(2):460-73.
PMID: 24492306
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kylaniemi M et al. (2014), The regulation and role of c-FLIP in human Th cell differentiation. PLoS ONE, 9(7):e102022.
PMID: 25019384
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Biancheri P et al. (2014), Absence of a role for interleukin-13 in inflammatory bowel disease. Eur J Immunol, 44(2):370-85.
PMID: 24338958
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Yu K et al. (2014), A p38 MAPK-mediated alteration of COX-2/PGE2 regulates immunomodulatory properties in human mesenchymal stem cell aging. PLoS ONE, 9(8):e102426.
PMID: 25090227
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wilde B et al. (2014), Signal tranducers and activators of transcription: expression and function in anti-neutrophil cytoplasmic antibody-associated vasculitis. Mol Med Rep, 9(6):2316-20.
PMID: 24676862
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ruan M et al. (2014), The secretion of IL-6 by CpG-ODN-treated cancer cells promotes T-cell immune responses partly through the TLR-9/AP-1 pathway in oral squamous cell carcinoma. Int J Oncol, 44(6):2103-10.
PMID: 24676671
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zhang M et al. (2014), Anti-beta(2)M monoclonal antibodies kill myeloma cells via cell- and complement-mediated cytotoxicity. Int J Cancer, 135(5):1132-41.
PMID: 24474467
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Liu W et al. (2014), Epstein-Barr virus infection induces indoleamine 2,3-dioxygenase expression in human monocyte-derived macrophages through p38/mitogen-activated protein kinase and NF-kappaB pathways: impairment in T cell functions. J Virol, 88(12):6660-71.
PMID: 24696473
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Martinelli R et al. (2014), Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance. J Cell Sci, 127(0):3720-34.
PMID: 25002404
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Leung J et al. (2014), IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue. Mucosal Immunol, 7(1):124-33.
PMID: 23695510
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Banu et al. (2014), Building and optimizing a virus-specific T cell receptor library for targeted immunotherapy in viral infections. Sci Rep, 4(0):4166.
PMID: 24566718
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Honda T et al. (2014), Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues. Immunity, 40(2):235-47.
PMID: 24440150
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lepore M et al. (2014), A novel self-lipid antigen targets human T cells against CD1c(+) leukemias. J Exp Med, 211(7):1363-77.
PMID: 24935257
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Siena L et al. (2014), Gemcitabine sensitizes lung cancer cells to Fas/FasL system-mediated killing. Immunology, 141(2):242-55.
PMID: 24128051
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kim H et al. (2014), Hepatitis C virus impairs natural killer cell-mediated augmentation of complement synthesis. J Virol, 88(5):2564-71.
PMID: 24352446
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Shipony et al. (2014), Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells. Nature, 513(7516):115-9.
PMID: 25043040
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Giese et al. (2014), Tetherin can restrict cell-free and cell-cell transmission of HIV from primary macrophages to T cells. PLoS Pathog, 10(7):e1004189.
PMID: 24991932
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Rutigliano et al. (2014), Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8+ T cells. J Virol, 88(3):1636-51.
PMID: 24257598
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Li H et al. (2014), Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection. PLoS Pathog, 10(12):e1004551.
PMID: 25503264
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kurachi M et al. (2014), The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells. Nat Immunol, 15(4):373-83.
PMID: 24584090
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Knosp C et al. (2013), Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2. J Immunol, 190(7):3235-45.
PMID: 23455506
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pihl M et al. (2013), Regulatory T cell phenotype and function 4 years after GAD-alum treatment in children with type 1 diabetes. Clin Exp Immunol, 172(3):394-402.
PMID: 23600827
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pliyev B et al. (2013), Neutrophil microparticles modulate cytokine production by natural killer cells. Cytokine, 65(2):126-9.
PMID: 24355430
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hawkins R et al. (2013), Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. Immunity, 38(6):1271-84.
PMID: 23791644
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Davila M et al. (2013), CD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia. PLoS ONE, 8(4):e61338.
PMID: 23585892
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Li W et al. (2013), Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18. PLoS ONE, 8(12):e82586.
PMID: 24376549
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Boisson B et al. (2013), An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. Immunity, 39(4):676-86.
PMID: 24120361
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sahaf B et al. (2013), H-Y antigen-binding B cells develop in male recipients of female hematopoietic cells and associate with chronic graft vs. host disease. Proc Natl Acad Sci U S A, 110(8):3005-10.
PMID: 23382226
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sharquie I et al. (2013), An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells. BMC Immunol, 14(0):54.
PMID: 24330349
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Guirnalda P et al. (2013), Interferon gamma-induced intratumoral expression of CXCL9 alters the local distribution of T cells following immunotherapy with Oncoimmunology, 2(8):e25752.
PMID: 24083082
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Srivastava R et al. (2013), Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients. Clin Cancer Res, 19(7):1858-72.
PMID: 23444227
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wu J et al. (2013), High mobility group nucleosomal binding domain 2 (HMGN2) SUMOylation by the SUMO E3 ligase PIAS1 decreases the binding affinity to nucleosome core particles. J Biol Chem, 289(29):20000-11.
PMID: 24872413
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pontikoglou C et al. (2013), Study of the quantitative, functional, cytogenetic, and immunoregulatory properties of bone marrow mesenchymal stem cells in patients with B-cell chronic lymphocytic leukemia. Stem Cells Dev, 22(9):1329-41.
PMID: 23249221
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

Oliveira R et al. (2013), Detection of TCD4+ subsets in human carotid atheroma. Cytokine, 62(1):131-40.
PMID: 23474106
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cai et al. (2013), A Lectin-EGF antibody promotes regulatory T cells and attenuates nephrotoxic nephritis via DC-SIGN on dendritic cells. J Transl Med, 11(0):103.
PMID: 23627732
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mujib S et al. (2012), Antigen-independent induction of Tim-3 expression on human T cells by the common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway. J. Immunol., 188(8):3745-56.
PMID: 22422881
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Emara M et al. (2012), Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite. J. Biol. Chem., 287(8):5756-63.
PMID: 22205703
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Huse K et al. (2012), Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma. PLoS ONE, 7(10):e46117.
PMID: 23049692
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bonanno G et al. (2012), Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma. J Transl Med, 10(0):247.
PMID: 23232072
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay

Goulart MR et al. (2012), Identification of myeloid derived suppressor cells in dogs with naturally occurring cancer. PLoS ONE, 7(3):e33274.
PMID: 22428007
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Li J et al. (2012), Tumor Microenvironment Macrophage Inhibitory Factor Directs the Accumulation of Interleukin-17-producing Tumor-infiltrating Lymphocytes and Predicts Favorable Survival in Nasopharyngeal Carcinoma Patients. J Biol Chem, 287(42):35484-95.
PMID: 22893706
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Brusic et al. (2012), Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients. Oncoimmunology, 1(7):1095-1103.
PMID: 23170257
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Levin AM et al. (2012), Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature, 484(7395):529-33.
PMID: 22446627
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Di Meglio P et al. (2011), The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans. PLoS ONE, 6(2):e17160.
PMID: 21364948
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Buglio D et al. (2011), HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma. Blood, 117(10):2910-7.
PMID: 21239696
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Raposo RA et al. (2011), Protein kinase C and NF-kappaB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection. J. Immunol., 187(2):748-59.
PMID: 21666058
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sabatte J et al. (2011), Semen clusterin is a novel DC-SIGN ligand. J. Immunol., 187(10):5299-309.
PMID: 22013110
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bowness P et al. (2011), Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis. J. Immunol., 186(0):2672.
PMID: 21248258
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hogan AE et al. (2011), Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis. Diabetologia, 54(11):2745-54.
PMID: 21744074
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ralainirina N et al. (2010), Mouse natural killer (NK) cells express the nerve growth factor receptor TrkA, which is dynamically regulated. PLoS ONE, 5(12):e15053.
PMID: 21152021
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Maarof G et al. (2010), Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells. Blood, 115(9):1718-26.
PMID: 19965640
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Heo YJ et al. (2010), IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients. Immunol. Lett., 127(2):150-6.
PMID: 19895848
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ungerer C et al. (2010), ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma. Biochem. Biophys. Res. Commun., 401(3):363-9.
PMID: 20851104
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lotem M et al. (2009), Autologous melanoma vaccine induces antitumor and self-reactive immune responses that affect patient survival and depend on MHC class II expression on vaccine cells. Clin. Cancer Res., 15(15):4968-77.
PMID: 19602547
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kwant-Mitchell A et al. (2009), Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge. PLoS ONE, 4(12):e8379.
PMID: 20027308
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Christophi GP et al. (2009), Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1. Clin. Immunol., 133(1):27-44.
PMID: 19559654
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Correale J et al. (2009), Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms. J. Immunol., 183(9):5999-6012.
PMID: 19812189
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lundqvist A et al. (2009), Bortezomib treatment and regulatory T-cell depletion enhance the antitumor effects of adoptively infused NK cells. Blood, 113(24):6120-7.
PMID: 19202127
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cattaruzza L et al. (2009), Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma. Int. J. Cancer, 125(5):1092-101.
PMID: 19391137
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hirosako S et al. (2009), Human bronchial intraepithelial T cells produce interferon-gamma and stimulate epithelial cells. Clin. Exp. Immunol., 155(2):266-74.
PMID: 19040600
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pfistershammer K et al. (2009), Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients. Blood, 114(11):2323-32.
PMID: 19617579
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kim-Schulze S et al. (2009), Local IL-21 promotes the therapeutic activity of effector T cells by decreasing regulatory T cells within the tumor microenvironment. Mol. Ther., 17(2):380-8.
PMID: 19034262
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Duraisingham SS et al. (2009), TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses. J. Immunol., 183(4):2242-51.
PMID: 19625644
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Witte K et al. (2009), Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun., 10(8):702-14.
PMID: 19798076
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Correale J et al. (2008), Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis. J. Neuroimmunol., 195(1):121-34.
PMID: 18234356
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Christophi GP et al. (2008), SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients. Lab. Invest., 88(3):243-55.
PMID: 18209728
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lai YG et al. (2008), IL-15 does not affect IEL development in the thymus but regulates homeostasis of putative precursors and mature CD8 alpha alpha+ IELs in the intestine. J. Immunol., 180(6):3757-65.
PMID: 18322181
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zheng CF et al. (2008), Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients. J. Immunol., 180(11):7221-9.
PMID: 18490721
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Miller R et al. (2008), Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay. J. Immunol. Methods, 334(1):134-41.
PMID: 18355834
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pene J et al. (2008), Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J. Immunol., 180(0):7423.
PMID: 18490742
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Correale J et al. (2008), Helminth infections associated with multiple sclerosis induce regulatory B cells. Ann. Neurol., 64(2):187-99.
PMID: 18655096
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rickel EA et al. (2008), Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J. Immunol., 181(6):4299-310.
PMID: 18768888
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Vossen MT et al. (2008), CD27 defines phenotypically and functionally different human NK cell subsets. J. Immunol., 180(6):3739-45.
PMID: 18322179
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Biancotto A et al. (2008), Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 24(3):453-62.
PMID: 18327985
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bayry J et al. (2007), Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells. J. Immunol., 178(7):4184-93.
PMID: 17371975
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bulanova E et al. (2007), Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15. J. Biol. Chem., 282(18):13167-79.
PMID: 17327231
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

de la Fuente MA et al. (2007), WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP). Proc. Natl. Acad. Sci. U.S.A., 104(3):926-31.
PMID: 17213309
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Schade AE et al. (2007), Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood, 111(3):1366-77.
PMID: 17962511
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gleissner CA et al. (2007), IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells. Eur. J. Immunol., 37(1):177-92.
PMID: 17163451
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Conrad C et al. (2007), Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat. Med., 13(7):836-42.
PMID: 17603494
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ruzek MC et al. (2007), Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo. Blood, 111(3):1726-34.
PMID: 18025149
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

De Fanis U et al. (2007), GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells. Blood, 109(10):4343-50.
PMID: 17234745
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Facco M et al. (2007), Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis. J. Leukoc. Biol., 82(4):946-55.
PMID: 17615381
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kosaka K et al. (2007), A synergistic antitumor effect of interleukin-2 addition with CD80 immunogene therapy for peritoneal metastasis of gastric carcinoma. Dig. Dis. Sci., 52(8):1946-53.
PMID: 17404853
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Toscano MA et al. (2007), Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat. Immunol., 8(8):825-34.
PMID: 17589510
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Seshasayee D et al. (2007), In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J. Clin. Invest., 117(12):3868-3878.
PMID: 18060034
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Pavon L et al. (2006), Th2 cytokine response in Major Depressive Disorder patients before treatment. J. Neuroimmunol., 172(1):156-65.
PMID: 16457895
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ebert EC et al. (2006), Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell. Immunol., 241(1):7-13.
PMID: 16914126
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Roda-Navarro P et al. (2006), Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function. Proc. Natl. Acad. Sci. U.S.A., 103(30):11258-63.
PMID: 16849432
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Johnson LA et al. (2006), An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J. Exp. Med., 203(12):2763-77.
PMID: 17116732
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

von Strandmann EP et al. (2006), A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo. Blood, 107(5):1955-62.
PMID: 16210338
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bourbie-Vaudaine S et al. (2006), Dendritic cells can turn CD4+ T lymphocytes into vascular endothelial growth factor-carrying cells by intercellular neuropilin-1 transfer. J. Immunol., 177(3):1460-9.
PMID: 16849452
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ancuta P et al. (2006), CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands. J. Immunol., 176(10):5760-71.
PMID: 16670281
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

Hirahara K et al. (2006), The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J. Immunol., 177(7):4488-94.
PMID: 16982885
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hanabuchi S et al. (2006), Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood, 107(9):3617-23.
PMID: 16397134
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dulos J et al. (2005), CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum., 52(3):770-8.
PMID: 15751070
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Schmidt CS et al. (2005), Resistance to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis by death receptor 6-deficient mice. J. Immunol., 175(4):2286-92.
PMID: 16081797
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Vasir B et al. (2005), Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism. J. Immunol., 174(4):2376-86.
PMID: 15699174
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Moreaux J et al. (2004), BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone. Blood, 103(8):3148-57.
PMID: 15070697
Species: Human

Applications: Bioassay

Megjugorac NJ et al. (2004), Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells. J. Leukoc. Biol., 75(3):504-14.
PMID: 14742635
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zheng SG et al. (2004), Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J. Immunol., 172(9):5213-21.
PMID: 15100259
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kao CY et al. (2004), IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol., 173(5):3482-91.
PMID: 15322213
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Holl V et al. (2004), Involvement of Fc gamma RI (CD64) in the mechanism of HIV-1 inhibition by polyclonal IgG purified from infected patients in cultured monocyte-derived macrophages. J. Immunol., 173(10):6274-83.
PMID: 15528366
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wang P et al. (2004), Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor. Biochem. J., 380(0):425-33.
PMID: 14992689
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Parham C et al. (2002), A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol., 168(11):5699-708.
PMID: 12023369
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wolk K et al. (2002), Cutting edge: immune cells as sources and targets of the IL-10 family members? J. Immunol., 168(11):5397-402.
PMID: 12023331
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Farah IO et al. (2000), Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4. J. Immunol., 164(10):5337-43.
PMID: 10799896
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Oppmann et al. (2000), Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity, 13(5):715-25.
PMID: 11114383
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nestle et al. (1998), Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med, 4(3):328-32.
PMID: 9500607
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Elias S et al. (0), TGF-beta Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner. Front Immuno7(0):603.
PMID: 28066414
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Schmidt A et al. (0), Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta. Immunol Cell Bio94(8):747-62.
PMID: 27075967
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Schmidt A et al. (0), Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate. PLoS ON11(2):e0148474.
PMID: 26886923
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Somasundaram A et al. (0), Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8+ T Cells. Cancer Immunol Re10(7):885-899.
PMID: 35587532
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Roudko V et al. (0), Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors. Cel183(6):1634-1649.e17.
PMID: 33259803

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FAQs for Recombinant Human IL-2 Protein

Why do some of R&D Systems proteins require reconstitution in an acidic buffer? Will this buffer hurt the cells?

Proteins should always be reconstituted and stored with the buffer recommended on the datasheet. Some proteins are extremely hydrophobic at neutral pH. If the suggested buffer is not used to reconstitute these proteins, they do not go fully into solution and much of the material may cling to the sides of the vial. When the protein is used for an assay, it can be diluted to working concentration with media or another suitable buffer which will neutralize the small amount of acid and make it safe to use with live cells.
Can Recombinant Human IL-2 Protein (Catalog # 202-IL) be reconstituted in PBS or water?

Recombinant Human IL-2 Protein (202-IL and 202-IL/CF) needs to be reconstituted to 100 μg/mL in sterile 100 mM Acetic Acid. Stability testing has been evaluated on the protein with these reconstitution conditions; we can guarantee performance under these reconstitution conditions. When the protein is diluted with the cell culture media or buffers to the working concentration, the concentration of the acid should be buffered or negligible.

Recombinant Human IL-2 Protein

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202-IL

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Background: IL-2

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Recombinant Human IL-2 Protein

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