Why does Recombinant Human IFN-gamma protein, Catalog # 285-IF, have the amio acid substitution R160Q?

Name: Recombinant Human IFN-gamma Protein
Brand: R&D Systems
SKU: 285-IF
Rating: 5 (22 reviews)

The sequence of R&D Systems' rhIFN-gamma, Catalog # 285-IF, is based on the the following publication in Nature:[https://www.ncbi.nlm.nih.gov/pubmed/?term=Gray+1982+503] Note that in figure 3, the article describes a Gln (Q) in position 160.

Recombinant Human IFN-gamma Protein

R&D Systems, Inc. a Bio-Techne Brand

Catalog # 285-IF

Citations (417)

(22)

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Analyzed by SEC-MALS

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Key Product Details

Source:	E. coli
Accession #:	CAA31639
Applications:	Bioactivity

View Full Technical Details for Recombinant Human IFN-gamma Protein

Product Specifications for Recombinant Human IFN-gamma Protein

Source	E. coli-derived human IFN-gamma protein Gln24-Gln166 with an N-terminal Met
Purity	>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin level	<0.01 EU per 1 μg of the protein by the LAL method.
N-terminal sequence Analysis	Met
Predicted Molecular Mass	16.9 kDa
SDS-PAGE	17 kDa, reducing conditions
Activity	Measured in anti-viral assays using HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. Meager, A. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 129. The ED₅₀ for this effect is 0.15-0.75 ng/mL.

Scientific Data Examples for Recombinant Human IFN-gamma Protein

	Recombinant Human IFN‑ gamma Protein SEC-MALS. Recombinant Human IFN-gamma (Catalog # 285-IF) has a molecular weight (MW) of 34.9 kDa as analyzed by SEC-MALS, suggesting that this protein is a homodimer. MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).
	Recombinant Human IFN-gamma Protein SDS-PAGE 1 μg/lane of Recombinant Human IFN-gamma was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 17 kDa.
	Recombinant Human IFN-gamma Protein Bioactivity Recombinant Human IFN-gamma (Catalog # 285‑IF) demonstrates anti-viral activity in HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. The activity is over 2-fold greater than the top competitor's IFN-gamma.

Formulation, Preparation and Storage

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

285-IF

Carrier

Formulation	Lyophilized from a 0.2 μm filtered solution in Sodium Succinate, Mannitol and Tween® 80 with BSA as a carrier protein.
Reconstitution	Reconstitute at 0.2 mg/mL in sterile, deionized water.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

285-IF/CF

Carrier Free

Formulation	Lyophilized from a 0.2 μm filtered solution in Sodium Succinate, Mannitol and Tween® 80.
Reconstitution	Reconstitute at 0.2 mg/mL in sterile, deionized water.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

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Background: IFN-gamma

Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature human IFN-gamma exists as a non-covalently linked homodimer of 20-25 kDa variably glycosylated subunits (3). It shares 90% amino acid (aa) sequence identity with rhesus IFN-gamma, 59%‑64% with bovine, canine, equine, feline, and porcine IFN‑ gamma, and 37%‑43% with cotton rat, mouse, and rat IFN-gamma. IFN-gamma dimers bind to IFN-gamma RI ( alpha subunits) which then interact with IFN-gamma RII ( beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction (4, 5). IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (6). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (6, 7). In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis (7).

Item	Value
References	Billiau, A. and P. Matthys (2009) Cytokine Growth Factor Rev. 20:97. Pestka, S. et al. (2004) Immunol. Rev. 202:8. Gray, P.W. and D.V. Goeddel (1982) Nature 298:859. Marsters, S.A. et al. (1995) Proc. Natl. Acad. Sci. 92:5401. Krause, C.D. et al. (2000) J. Biol. Chem. 275:22995. Schroder, K. et al. (2004) J. Leukoc. Biol. 75:163. McLaren, J.E. and D.P. Ramji (2009) Cytokine Growth Factor Rev. 20:125. Muhl, H. and J. Pfeilschifter (2003) Int. Immunopharmacol. 3:1247. Kelchtermans, H. et al. (2008) Trends Immunol. 29:479.
Long Name	Interferon gamma
Entrez Gene IDs	3458 (Human); 15978 (Mouse); 25712 (Rat); 396991 (Porcine); 281237 (Bovine); 403801 (Canine); 493965 (Feline)
Alternate Names	IFG, IFI, IFN-gamma, IFNG, IFNgamma, Immune interferon, interferon gamma, interferon, gamma

Citations for Recombinant Human IFN-gamma Protein (417)

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Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human IFN-gamma Protein include:

Species: Human
Sample Types: Whole Cells
Applications: Bioassay

PL Chi et al. (2022-01-01), MMP-10 from M1 macrophages promotes pulmonary vascular remodeling and pulmonary arterial hypertension International journal of biological sciences, 18(1):331-348.
PMID: 34975336
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

P Sekhri et al. (2022-01-01), The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells Cancers, 14(6).
PMID: 35326601
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Schmit et al. (2022-01-01), Interferon-gamma promotes monocyte-mediated lung injury during influenza infection Cell Reports, 38(9):110456.
PMID: 35235782
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Hong et al. (2022-01-01), Dendrobium nobile Lindley Administration Attenuates Atopic Dermatitis-like Lesions by Modulating Immune Cells International Journal of Molecular Sciences, 23(8).
PMID: 35457288
Species: Human
Sample Types: Whole Cell
Applications: Bio-assay

DY Zander et al. (2022-01-01), Cooperative effects of RIG-I-like receptor signaling and IRF1 on DNA damage-induced cell death Cell Death Disease, 2022;13(4):364.
PMID: 35436994
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Fedoriw et al. (2022-01-01), Inhibiting Type I arginine methyltransferase activity promotes the T cell mediated antitumor immune response Cancer Immunology Research, 0(0).
PMID: 35181787
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Mitra et al. (2022-01-01), Microglia Impairs Proliferation and Induces Senescence In-Vitro in NGF Releasing Cells Used in Encapsulated Cell Biodelivery for Alzheimer's Disease Therapy International Journal of Molecular Sciences, 23(16).
PMID: 36012296
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Casciola-R et al. (2022-01-01), IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function JCI Insight, 7(9).
PMID: 35349483
Species: Human
Sample Types: Whole Cell
Applications: Cell Culture

T Meyer et al. (2022-01-01), NAD+ metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity Proceedings of the National Academy of Sciences of the United States of America, 119(35):e2211310119.
PMID: 35994674
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Chandrasek et al. (2022-01-01), IFN-gamma stimulated murine and human neurons mount anti-parasitic defenses against the intracellular parasite Toxoplasma gondii Nature Communications, 13(1):4605.
PMID: 35941154
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CW Lee et al. (2022-01-01), Demystifying the long noncoding RNA landscape of small EVs derived from human mesenchymal stromal cells Journal of advanced research, 39(0):73-88.
PMID: 35777918
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Yoshinaga et al. (2022-01-01), Long-term survival in non-human primates of stem cell-derived, MHC-unmatched corneal epithelial cell sheets Stem Cell Reports, 0(0).
PMID: 35750044
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Iverson et al. (2022-01-01), Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium MBio, 0(0):e0105522.
PMID: 35699372
Species: Human
Sample Types: Organoid
Applications: Bioassay

P Pavlidis et al. (2022-01-01), Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease Cell Reports, 40(13):111439.
PMID: 36170836
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

XJ Mi et al. (2022-01-01), In vitro assessment of the anti-inflammatory and skin-moisturizing effects of Filipendula palmata (Pall.) Maxim. On human keratinocytes and identification of its bioactive phytochemicals Journal of ethnopharmacology, 296(0):115523.
PMID: 35809756
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Z Zhang et al. (2022-01-01), Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity Nature Communications, 13(1):4136.
PMID: 35842425
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Padmanabha et al. (2022-01-01), IFNgamma-induced PD-L1 expression in ovarian cancer cells is regulated by JAK1, STAT1 and IRF1 signaling Cellular Signalling, 97(0):110400.
PMID: 35820543
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

MD Gundersen et al. (2022-01-01), Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis Scientific Reports, 12(1):11550.
PMID: 35798804
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

H Asashima et al. (2022-01-01), PD-1highCXCR5-CD4+ peripheral helper Tï¿½cells promote CXCR3+ plasmablasts in human acute viral infection Cell Reports, 0(0):111895.
PMID: 36596303
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Hayashi et al. (2022-01-01), Intestinal epithelial BLT1 promotes mucosal repair JCI Insight, 0(0).
PMID: 36301666
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Turner et al. (2022-01-01), CRISPR/Cas9 Edited RAS & MEK Mutant Cells Acquire BRAF and MEK Inhibitor Resistance with MEK1 Q56P Restoring Sensitivity to MEK/BRAF Inhibitor Combo and KRAS G13D Gaining Sensitivity to Immunotherapy Cancers, 14(21).
PMID: 36358868
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

AC Tecalco-Cr et al. (2021-01-01), Identification of genes modulated by interferon gamma in breast cancer cells Biochemistry and Biophysics Reports, 27(0):101053.
PMID: 34189281
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MC Suárez-Arr et al. (2021-01-01), Claudin-Low Breast Cancer Inflammatory Signatures Support Polarization of M1-Like Macrophages with Protumoral Activity Cancers, 13(9).
PMID: 34067089
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BY Wang et al. (2021-01-01), Stress increases MHC-I expression in dopaminergic neurons and induces autoimmune activation in Parkinson's disease Neural regeneration research, 16(12):2521-2527.
PMID: 33907043
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SP Totten et al. (2021-01-01), STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer Nature Communications, 12(1):3299.
PMID: 34083537
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

YH Liang et al. (2021-01-01), Chemotherapy agents stimulate dendritic cells against human colon cancer cells through upregulation of the transporter associated with antigen processing Scientific Reports, 11(1):9080.
PMID: 33907276
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

R Luna-Yolba et al. (2021-01-01), Disrupting Mitochondrial Electron Transfer Chain Complex I Decreases Immune Checkpoints in Murine and Human Acute Myeloid Leukemic Cells Cancers, 13(14).
PMID: 34298712
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Luostarine et al. (2021-01-01), The inflammatory regulation of TRPA1 expression in human A549 lung epithelial cells Pulmonary pharmacology therapeutics, 2021;70(0):102059.
PMID: 34302984
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

D Lobato-Már et al. (2021-01-01), Mechanistic insight into bacterial entrapment by septin cage reconstitution Nature Communications, 12(1):4511.
PMID: 34301939
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA (Capture)

JS Aguilar Dí et al. (2021-01-01), Oxidized-Desialylated Low-Density Lipoprotein Inhibits the Antitumor Functions of Lymphokine Activated Killer Cells Journal of Cancer, 12(16):4993-5004.
PMID: 34234868
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

X Yang et al. (2021-01-01), FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat MBio, 0(0):e0079521.
PMID: 34281390
Species: Human
Sample Types: Organoid
Applications: Bioassay

C Prelli Boz et al. (2021-01-01), IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro Nature Communications, 12(1):4584.
PMID: 34321474
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Nakajima et al. (2021-01-01), The effects of T-DXd on the expression of HLA class I and chemokines CXCL9/10/11 in HER2-overexpressing gastric cancer cells Scientific Reports, 11(1):16891.
PMID: 34413454
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Azari et al. (2021-01-01), Hofbauer Cells Spread Listeria monocytogenes among Placental Cells and Undergo Pro-Inflammatory Reprogramming while Retaining Production of Tolerogenic Factors MBio, 12(4):e0184921.
PMID: 34399615
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

XY Zhu et al. (2021-01-01), Impaired immunomodulatory capacity in adipose tissue-derived mesenchymal stem/stromal cells isolated from obese patients Journal of Cellular and Molecular Medicine, 0(0).
PMID: 34418300
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Abu-Shahba et al. (2021-01-01), Impact of Type 2 Diabetes Mellitus on the Immunoregulatory Characteristics of Adipose Tissue-Derived Mesenchymal Stem Cells The international journal of biochemistry cell biology, 2021;0(0):106072.
PMID: 34455058
Species: Human
Sample Types: Whole Cell
Applications: Stimulation

S Wüst et al. (2021-01-01), Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses Cells, 10(10).
PMID: 34685580
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Wang et al. (2021-01-01), SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms Scientific Reports, 11(1):1399.
PMID: 33446805
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Gunawardan et al. (2021-01-01), Tissue-specific endothelial cell heterogeneity contributes to unequal inflammatory responses Scientific Reports, 11(1):1949.
PMID: 33479269
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Shao et al. (2021-01-01), Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris JCI Insight, 0(0).
PMID: 34491907
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TM Garcia-Bat et al. (2021-01-01), Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes EBioMedicine, 63(0):103175.
PMID: 33450518
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Jerby-Arno et al. (2021-01-01), Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma Nature Medicine, 0(0).
PMID: 33495604
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

HJ Lee et al. (2021-01-01), IFN-gamma Licensing Does Not Enhance the Reduced Immunomodulatory Potential and Migratory Ability of Differentiation-Induced Porcine Bone Marrow-Derived Mesenchymal Stem Cells in an In Vitro Xenogeneic Application BioMed Research International, 2021(0):4604856.
PMID: 34527737
Species: Human
Sample Types: Organoid
Applications: Bioassay

Y Cheng et al. (2021-01-01), Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease EBioMedicine, 75(0):103758.
PMID: 34933179
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SR Rosenbaum et al. (2021-01-01), SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects Cell Reports, 37(10):110085.
PMID: 34879275
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Song et al. (2021-01-01), Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation Nucleic Acids Research, 0(0).
PMID: 34791430
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

A Fu et al. (2021-01-01), Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets Cell Reports, 37(8):110037.
PMID: 34818536
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Kim et al. (2021-01-01), TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment Cell Reports, 37(7):110018.
PMID: 34788612
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

YH Liang et al. (2021-01-01), Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells Journal of Biomedical Science, 28(1):75.
PMID: 34758826
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Pettmann et al. (2021-01-01), The discriminatory power of the T cell receptor Elife, 10(0).
PMID: 34030769
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

J Kim et al. (2021-01-01), A Novel Kinase Inhibitor AX-0085 Inhibits Interferon-gamma-Mediated Induction of PD-L1 Expression and Promotes Immune Reaction to Lung Adenocarcinoma Cells Cells, 11(1).
PMID: 35011581
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

C Xu et al. (2021-01-01), Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-kappaB signaling The Journal of Biological Chemistry, 0(0):101380.
PMID: 34740611
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Lee et al. (2021-01-01), Skullcapflavone II Suppresses TNF-alpha/IFN-gamma-Induced TARC, MDC, and CTSS Production in HaCaT Cells International Journal of Molecular Sciences, 22(12).
PMID: 34208434
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Seime et al. (2021-01-01), Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification Cells, 10(6).
PMID: 34063989
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ML Amin et al. (2020-01-01), Immunomodulatory properties of photopolymerizable fucoidan and carrageenans Carbohydr Polym, 230(0):115691.
PMID: 31887956
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

K Yoshida et al. (2020-01-01), Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells BMC Cancer, 20(1):25.
PMID: 31914969
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

YD Kim et al. (2020-01-01), HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment J Cancer, 11(14):4059-4072.
PMID: 32368288
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Shan et al. (2020-01-01), Resolvin D1 and D2 inhibit tumour growth and inflammation via modulating macrophage polarization J. Cell. Mol. Med., 0(0).
PMID: 32469149
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Liu et al. (2020-01-01), Targeting macrophage checkpoint inhibitor SIRPa for anticancer therapy JCI Insight, 0(0).
PMID: 32427583
Species: Human

Applications: Cell Culture

H Ray-Jones et al. (2020-01-01), Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31 BMC Biol., 18(1):47.
PMID: 32366252
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

MN Dehno et al. (2020-01-01), Increase in Efficacy of Checkpoint Inhibition by Cytokine-Induced-Killer Cells as a Combination Immunotherapy for Renal Cancer Int J Mol Sci, 21(9).
PMID: 32349280
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

D Zhu et al. (2020-01-01), Macrophage M2 polarization induced by exosomes from adipose-derived stem cells contributes to the exosomal proangiogenic effect on mouse ischemic hindlimb Stem Cell Res Ther, 11(1):162.
PMID: 32321589
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

AM Kell et al. (2020-01-01), RIG-I-like receptor activation drives type I IFN and antiviral signaling to limitï¿½Hantaan orthohantavirus replication PLoS Pathog., 16(4):e1008483.
PMID: 32330200
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

A Nikonova et al. (2020-01-01), M1-like macrophages are potent producers of anti-viral interferons and M1-associated marker-positive lung macrophages are decreased during rhinovirus-induced asthma exacerbations EBioMedicine, 54(0):102734.
PMID: 32279057
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MY Hsieh et al. (2020-01-01), Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES) Biomed J, 0(0).
PMID: 32651134
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

H El-Kehdy et al. (2020-01-01), Inflammation Differentially Modulates the Biological Features of Adult Derived Human Liver Stem/Progenitor Cells Cells, 9(7).
PMID: 32650454
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

NC Leite et al. (2020-01-01), Modeling Type 1 Diabetes Inï¿½Vitro Using Human Pluripotent Stem Cells Cell Rep, 32(2):107894.
PMID: 32668238
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

C Su et al. (2020-01-01), Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells Nat Commun, 11(1):3294.
PMID: 32620744
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

K Das Gupta et al. (2020-01-01), Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2 Cell Rep, 30(8):2712-2728.e8.
PMID: 32101747
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JF Marchini et al. (2020-01-01), Oxidized Low-Density Lipoprotein Induces Macrophage Production of Prothrombotic Microparticles J Am Heart Assoc, 9(15):e015878.
PMID: 32750308
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

R Abreu et al. (2020-01-01), Interferon-gamma promotes iron export in human macrophages to limit intracellular bacterial replication PLoS ONE, 15(12):e0240949.
PMID: 33290416
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

J Bhushan et al. (2020-01-01), ISG15 Connects Autophagy and IFN-&gamma-Dependent Control of Toxoplasma gondii Infection in Human Cells MBio, 11(5).
PMID: 33024031
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

T Nicotra et al. (2020-01-01), Mesenchymal stem/stromal cell quality control: validation of mixed lymphocyte reaction assay using flow cytometry according to ICH Q2(R1) Stem Cell Res Ther, 11(1):426.
PMID: 33004063
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Abu-Shah et al. (2020-01-01), Human CD8+ T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses J. Immunol., 0(0).
PMID: 32817332
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

V Panagiotak et al. (2020-01-01), Interferon-&gamma signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells Nat Commun, 11(1):5163.
PMID: 33057020
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

X Li et al. (2020-01-01), 18F-FHBG PET-CT Reporter Gene Imaging of Adoptive CIK Cell Transfer Immunotherapy for Breast Cancer in a Mouse Model Onco Targets Ther, 13(0):11659-11668.
PMID: 33223839
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

B Cioni et al. (2020-01-01), Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion Nat Commun, 11(1):4498.
PMID: 32908142
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

B ?y?y?ska-G et al. (2020-01-01), The anti-inflammatory potential of cefazolin as common gamma chain cytokine inhibitor Sci Rep, 10(1):2886.
PMID: 32076052
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Yan et al. (2020-01-01), T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Cell Rep, 31(13):107820.
PMID: 32610123
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Wu et al. (2020-01-01), Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis Cell Res., 0(0).
PMID: 32546764
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Kim et al. (2020-01-01), Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia Cells, 9(9).
PMID: 32878300
Species: Human
Sample Types: Whole Cells

ZZ Bai et al. (2020-01-01), M1 Macrophage-Derived Exosomal MicroRNA-326 Suppresses Hepatocellular Carcinoma Cell Progression Via Mediating NF-&kappaB Signaling Pathway Nanoscale research letters, 15(1):221.
PMID: 33263825
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

EM Wilfong et al. (2020-01-01), Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation PLoS ONE, 15(10):e0240319.
PMID: 33021986
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Yakimovich et al. (2020-01-01), Mimicry Embedding Facilitates Advanced Neural Network Training for Image-Based Pathogen Detection mSphere, 5(5).
PMID: 32907956
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

C Li et al. (2020-01-01), Repurposing screen identifies Amlodipine as an inducer of PD-L1 degradation and antitumor immunity Oncogene, 0(0).
PMID: 33323966
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

D Fisch et al. (2020-01-01), Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death Cell Rep, 32(6):108008.
PMID: 32783936
Species: Human
Sample Types: Protein
Applications: Bioassay

SA Tarasov et al. (2020-01-01), Insights into the Mechanism of Action of Highly Diluted Biologics J. Immunol., 0(0).
PMID: 32727888
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Gustafsson et al. (2020-01-01), Effect of IFN-gamma on the kynurenine/tryptophan ratio in monolayer-cultured keratinocytes and a 3D reconstructed human epidermis model J. Dermatol. Sci., 0(0).
PMID: 32782183
Species: Human
Sample Types: Whole Cells
Applications: Bioassay, Cell Culture

F Duan et al. (2020-01-01), Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq, 0(0).
PMID: 32839764
Species: Human
Sample Types: Protein
Applications: Bioassay

MC Cavé et al. (2020-01-01), Glycosaminoglycans bind human IL-27 and regulate its activity Eur. J. Immunol., 0(0).
PMID: 32483835
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AL Samson et al. (2020-01-01), MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis Nat Commun, 11(1):3151.
PMID: 32561730
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Gettler et al. (2019-01-01), Prioritizing Crohn's disease genes by integrating association signals with gene expression implicates monocyte subsets Genes Immun., 0(0).
PMID: 30692607
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Cruz-Ramos et al. (2019-01-01), Non-muscle myosin IIA is post-translationally modified by interferon-stimulated gene 15 in breast cancer cells Int. J. Biochem. Cell Biol., 107(0):14-26.
PMID: 30529400
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Spekker-Bo et al. (2019-01-01), hCMV-Mediated Immune Escape Mechanisms Favor Pathogen Growth and Disturb the Immune Privilege of the Eye Int J Mol Sci, 20(4).
PMID: 30781494
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SE Jin et al. (2019-01-01), Anti-Allergic and Anti-Inflammatory Effects of Kuwanon G and Morusin on MC/9 Mast Cells and HaCaT Keratinocytes Molecules, 24(2).
PMID: 30642008
Species: Human

Applications: Bioassay

F Feng et al. (2019-01-01), Preexisting Virus-Specific T Lymphocytes-Mediated Enhancement of Adenovirus Infections to Human Blood CD14+ Cells Viruses, 11(2).
PMID: 30781810
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BA Kane et al. (2019-01-01), Differential expression and regulation of the non-integrin 37/67-kDa laminin receptor on peripheral blood leukocytes of healthy individuals and patients with rheumatoid arthritis Sci Rep, 9(1):1149.
PMID: 30718719
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Kita et al. (2019-01-01), Identification of P2Y receptors involved in oleamide-suppressing inflammatory responses in murine microglia and human dendritic cells Sci Rep, 9(1):3135.
PMID: 30816271
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Karnezis et al. (2019-01-01), CCL27/CCL28-CCR10 CHEMOKINE SIGNALING MEDIATES MIGRATION OF LYMPHATIC ENDOTHELIAL CELLS Cancer Res., 0(0).
PMID: 30709930
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JC de Quaglia et al. (2019-01-01), Involvement of the Dectin-1 Receptor upon the Effector Mechanisms of Human Phagocytic Cells against Paracoccidioides brasiliensis J Immunol Res, 2019(0):1529189.
PMID: 30882002
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Ashizawa et al. (2019-01-01), microRNA-148a-3p regulates immunosuppression in DNA mismatch repair-deficient colorectal cancer by targeting PD-L1 Mol. Cancer Res., 0(0).
PMID: 30872332
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Roper et al. (2019-01-01), APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors Cell Rep, 26(10):2651-2666.e6.
PMID: 30840888
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AT Dang et al. (2019-01-01), Autophagy links antimicrobial activity with antigen presentation in Langerhans cells JCI Insight, 4(8).
PMID: 30996142
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Vander Bek et al. (2019-01-01), Newly defined ABCB5+ dermal mesenchymal stem cells promote healing of chronic iron overload wounds via secretion of interleukin-1 receptor antagonist Stem Cells, 0(0).
PMID: 31002437
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Ruiz et al. (2019-01-01), DNA from virulent M. tuberculosis induces TNF-? production and autophagy in M1 polarized macrophages Microb. Pathog., 0(0).
PMID: 31054870
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CH Yu et al. (2019-01-01), Inhibitory Effects of a Novel Chrysin-Derivative, CPD 6, on Acute and Chronic Skin Inflammation Int J Mol Sci, 20(11).
PMID: 31141897
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SM Ferrari et al. (2019-01-01), Differential modulation of CXCL8 versus CXCL10, by cytokines, PPAR-gamma, or PPAR-alpha agonists, in primary cells from Graves' disease and ophthalmopathy Autoimmun Rev, 0(0).
PMID: 31059842
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Wu et al. (2019-01-01), IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells J. Immunol., 0(0).
PMID: 31548328
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

C Ménard et al. (2019-01-01), Integrated Transcriptomic, Phenotypic, and Functional Study Reveals Tissue-Specific Immune Properties of Mesenchymal Stromal Cells Stem Cells, 0(0).
PMID: 31502731
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

C Merriman et al. (2019-01-01), Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress J. Biol. Chem., 0(0).
PMID: 31591269
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

LNS Andrade et al. (2019-01-01), Extracellular Vesicles Shedding Promotes Melanoma Growth in Response to Chemotherapy Sci Rep, 9(1):14482.
PMID: 31597943
Species: Human
Sample Types: Serum
Applications: ELISA Standard

A Stumpf et al. (2019-01-01), Hydrogel based protein biochip for parallel detection of biomarkers for diagnosis of a Systemic Inflammatory Response Syndrome (SIRS) in human serum PLoS ONE, 14(12):e0225525.
PMID: 31790441
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

D Deli? et al. (2019-01-01), Integrated microRNA/mRNA expression profiling of the skin of psoriasis patients J. Dermatol. Sci., 0(0).
PMID: 31843230
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

LA Callender et al. (2019-01-01), Mitochondrial mass governs the extent of human T cell senescence Aging Cell, 0(0):e13067.
PMID: 31788930
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

N Berges et al. (2019-01-01), Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform PLoS ONE, 14(11):e0225081.
PMID: 31703097
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

E Biros et al. (2019-01-01), Mini tryptophanyl-tRNA synthetase is required for a synthetic phenotype in vascular smooth muscle cells induced by IFN-?-mediated beta2-adrenoceptor signaling Cytokine, 127(0):154940.
PMID: 31786502
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

SM Huang et al. (2019-01-01), High glucose environment induces M1 macrophage polarization that impairs keratinocyte migration via TNF-alpha: An important mechanism to delay the diabetic wound healing J. Dermatol. Sci., 0(0).
PMID: 31761388
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

WB Hamilton et al. (2019-01-01), Dynamic lineage priming is driven via direct enhancer regulation by ERK Nature, 575(7782):355-360.
PMID: 31695196
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

KA Jha et al. (2019-01-01), TSG-6 in conditioned media from adipose mesenchymal stem cells protects against visual deficits in mild traumatic brain injury model through neurovascular modulation Stem Cell Res Ther, 10(1):318.
PMID: 31690344
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

W Nowak et al. (2019-01-01), Pro-inflammatory monocyte profile in patients with major depressive disorder and suicide behaviour and how ketamine induces anti-inflammatory M2 macrophages by NMDAR and mTOR EBioMedicine, 0(0).
PMID: 31753725
Species: Human
Sample Types: Organoid
Applications: Bioassay

M Pascual-Ga et al. (2019-01-01), LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy Nat Commun, 10(1):2416.
PMID: 31186412
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KJ Pahk et al. (2019-01-01), Boiling Histotripsy-induced Partial Mechanical Ablation Modulates Tumour Microenvironment by Promoting Immunogenic Cell Death of Cancers Sci Rep, 9(1):9050.
PMID: 31227775
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

X Zhang et al. (2018-01-01), Antigen presentation of the Oct4 and Sox2 peptides by CD154-activated B lymphocytes enhances the killing effect of cytotoxic T lymphocytes on tumor stem-like cells derived from cisplatin-resistant lung cancer cells J Cancer, 9(2):367-374.
PMID: 29344283
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Nakagawa et al. (2018-01-01), Intratumoral delivery of an adenoviral vector carrying the SOCS-1 gene enhances T cell-mediated anti-tumor immunity by suppressing PD-L1 Mol. Cancer Ther., 0(0).
PMID: 29891489
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

EY Huang et al. (2018-01-01), Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages BMC Cancer, 18(1):321.
PMID: 29580202
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

W Vermi et al. (2018-01-01), slan+ monocytes and macrophages mediate CD20-dependent B cell lymphoma elimination via ADCC and ADCP Cancer Res., 0(0).
PMID: 29748373
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

LCD Smyth et al. (2018-01-01), Unique and shared inflammatory profiles of human brain endothelia and pericytes J Neuroinflammation, 15(1):138.
PMID: 29751771
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

D Sireesh et al. (2018-01-01), Association of NF-E2 Related Factor 2 (Nrf2) and inflammatory cytokines in recent onset Type 2 Diabetes Mellitus Sci Rep, 8(1):5126.
PMID: 29572460
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

G Genard et al. (2018-01-01), Proton irradiation orchestrates macrophage reprogramming through NF?B signaling Cell Death Dis, 9(7):728.
PMID: 29950610
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Nagel et al. (2018-01-01), Aberrant expression of NKL homeobox gene HLX in Hodgkin lymphoma Oncotarget, 9(18):14338-14353.
PMID: 29581848
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KC Osum et al. (2018-01-01), Interferon-gamma drives programmed death-ligand 1 expression on islet ? cells to limit T cell function during autoimmune diabetes Sci Rep, 8(1):8295.
PMID: 29844327
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S McGarrity et al. (2018-01-01), Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification Sci Rep, 8(1):6811.
PMID: 29717213
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Palazzo et al. (2018-01-01), The PI3K?-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augments B Cell Depletion In Vivo J. Immunol., 0(0).
PMID: 29453281
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JA Marwick et al. (2018-01-01), Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-?B activation Cell Death Dis, 9(6):665.
PMID: 29867198
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Sugita et al. (2018-01-01), Natural Killer Cell Inhibition by HLA-E Molecules on Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells Invest. Ophthalmol. Vis. Sci., 59(5):1719-1731.
PMID: 29610856
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Vorkapic et al. (2018-01-01), Effects of osteoprotegerin/TNFRSF11B in two models of abdominal aortic aneurysms Mol Med Rep, 0(0).
PMID: 29749489
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Oth et al. (2018-01-01), Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-? BMC Immunol., 19(1):8.
PMID: 29433450
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AE Dodi et al. (2018-01-01), Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli Respir. Res., 19(1):91.
PMID: 29747634
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

C Lema et al. (2018-01-01), High-Mobility Group Box 1 in Dry Eye Inflammation Invest. Ophthalmol. Vis. Sci., 59(5):1741-1750.
PMID: 29610858
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RB Nahomi et al. (2018-01-01), The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice Invest. Ophthalmol. Vis. Sci., 59(5):2042-2053.
PMID: 29677366
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Huang et al. (2018-01-01), MicroRNA-374b inhibits liver cancer progression via down regulating programmed cell death-1 expression on cytokine-induced killer cells Oncol Lett, 15(4):4797-4804.
PMID: 29552119
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Oshima et al. (2018-01-01), Virus-like infection induces human ? cell dedifferentiation JCI Insight, 3(3).
PMID: 29415896
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Singh et al. (2018-01-01), Antimycobacterial effect of IFNG (interferon gamma)-induced autophagy is dependent on the HMOX1 (heme oxygenase 1)-mediated increase in the intracellular calcium levels and modulation of PPP3/calcineurin-TFEB (transcription factor EB) axis Autophagy, 0(0):1-57.
PMID: 29457983
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Schwede et al. (2018-01-01), Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-?, IL-1?, and IFN-? Physiol Rep, 6(16):e13831.
PMID: 30136410
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MA Terkawi et al. (2018-01-01), Differential Gene Expression Profile of Human Neutrophils Cultured with Plasmodium falciparum-Parasitized Erythrocytes J Immunol Res, 2018(0):6709424.
PMID: 30069491
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SL Figenschau et al. (2018-01-01), ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes Sci Rep, 8(1):11720.
PMID: 30082828
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Zou et al. (2018-01-01), The proto-oncogene Bcl3 induces immune checkpoint PD-L1 expression, mediating proliferation of ovarian cancer cells J. Biol. Chem., 0(0).
PMID: 30135206
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

NM Plugis et al. (2018-01-01), Interleukin 4 is inactivated via selective disulfide-bond reduction by extracellular thioredoxin Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 30104382
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CH Lu et al. (2018-01-01), USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation Oncogene, 0(0).
PMID: 30038267
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay

I Cañadas et al. (2018-01-01), Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses Nat. Med., 0(0).
PMID: 30038220
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ED Anderson et al. (2018-01-01), Prolonging culture of primary human keratinocytes isolated from suction blisters with the Rho kinase inhibitor Y-27632 PLoS ONE, 13(9):e0198862.
PMID: 30208113
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Yang et al. (2018-01-01), Co-culture of dendritic cells and cytokine-induced killer cells effectively suppresses liver cancer stem cell growth by inhibiting pathways in the immune system BMC Cancer, 18(1):984.
PMID: 30326865
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TJ Bussian et al. (2018-01-01), Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline Nature, 0(0).
PMID: 30232451
Species: Human
Sample Types: Plasma

J Hrdý et al. (2018-01-01), Decreased allergy incidence in children supplemented with E. coli O83:K24:H31 and its possible modes of action Eur. J. Immunol., 0(0).
PMID: 30306557
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AC Tecalco-Cr et al. (2018-01-01), Interplay between interferon-stimulated gene 15/ISGylation and interferon gamma signaling in breast cancer cells Cell. Signal., 54(0):91-101.
PMID: 30500379
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ML Ibrahim et al. (2018-01-01), Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis Cell Rep, 25(11):3036-3046.e6.
PMID: 30540937
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Vaeteewoot et al. (2018-01-01), Attenuation of CD47-SIRP? Signal in Cholangiocarcinoma Potentiates Tumor-Associated Macrophage-Mediated Phagocytosis and Suppresses Intrahepatic Metastasis Transl Oncol, 12(2):217-225.
PMID: 30415063
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

DA Bejarano et al. (2018-01-01), Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages Viruses, 10(11).
PMID: 30423802
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Muntaka et al. (2018-01-01), IFN-? and IL-17A differentially influence the response of human macrophages and neutrophils to Pseudomonas aeruginosa infection Infect. Immun., 0(0).
PMID: 30455194
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HK Park et al. (2018-01-01), Status of programmed death-ligand 1 expression in sarcomas J Transl Med, 16(1):303.
PMID: 30400799
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Tomi? et al. (2018-01-01), Functionalization-dependent effects of cellulose nanofibrils on tolerogenic mechanisms of human dendritic cells Int J Nanomedicine, 13(0):6941-6960.
PMID: 30464452
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Mulati et al. (2018-01-01), VISTA expressed in tumour cells regulates T cell function Br. J. Cancer, 0(0).
PMID: 30382166
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Rentschler et al. (2018-01-01), Nuclear Translocation of Argonaute 2 in Cytokine-Induced Senescence Cell. Physiol. Biochem., 51(3):1103-1118.
PMID: 30476917
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Mercurio et al. (2018-01-01), IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment Cell Death Dis, 9(11):1104.
PMID: 30377293
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Zhou et al. (2018-01-01), Exosomes released from tumor-associated macrophages transfer miRNAs that induce a Treg/Th17 cell imbalance in epithelial ovarian cancer Cancer Immunol Res, 0(0).
PMID: 30396909
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

WY Lei et al. (2018-01-01), Total HLA Class I Antigen Loss with the Downregulation of Antigen-Processing Machinery Components in Two Newly Established Sarcomatoid Hepatocellular Carcinoma Cell Lines J Immunol Res, 2018(0):8363265.
PMID: 30648121
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Bai et al. (2018-01-01), Guanylate-Binding Protein 1 Promotes Migration and Invasion of Human Periodontal Ligament Stem Cells Stem Cells Int, 2018(0):6082956.
PMID: 30622567
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Sun et al. (2018-01-01), INF-?: A new spotlight in innate immunity against influenza virus infection Protein Cell, 0(0).
PMID: 29332267
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TA Nakada et al. (2018-01-01), The IL20 Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock J Innate Immun, 0(0).
PMID: 29334679
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

DJ Sharkey et al. (2018-01-01), Interferon-gamma inhibits seminal plasma induction of colony stimulating factor 2 in mouse and human reproductive tract epithelial cells Biol. Reprod., 0(0).
PMID: 29596569
Species: Human
Sample Types: Whole Cells
Applications: Differentiation, Differentiation

MW Tang et al. (2018-01-01), Class 3 semaphorins modulate the invasive capacity of rheumatoid arthritis fibroblast-like synoviocytes Rheumatology (Oxford), 0(0).
PMID: 29471421
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

AJ Lakhter et al. (2018-01-01), Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes Diabetologia, 0(0).
PMID: 29445851
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Huang et al. (2018-01-01), The RNA-binding protein MEX3B mediates resistance to cancer immunotherapy by downregulating HLA-Aï¿½expression Clin. Cancer Res., 0(0).
PMID: 29496759
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TD Jung et al. (2018-01-01), Changes in the Anti-Allergic Activities of Sesame by Bioconversion Nutrients, 10(2).
PMID: 29443928
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

WR Swindell et al. (2018-01-01), RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature Front Immunol, 9(0):80.
PMID: 29434599
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

C Breuker et al. (2018-01-01), Decreased RNF41 expression leads to insulin resistance in skeletal muscle of obese women Metab. Clin. Exp., 0(0).
PMID: 29410345
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Ilic et al. (2018-01-01), Trichinella spiralis Excretory-Secretory Products Induce Tolerogenic Properties in Human Dendritic CellsviaToll-Like Receptors 2 and 4 Front Immunol, 9(0):11.
PMID: 29416536
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CW Li et al. (2018-01-01), Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1 Cancer Cell, 33(2):187-201.e10.
PMID: 29438695
Species: Human
Sample Types: Whole Cells
Applications: Differentiation, Differentiation

I Pop?na et al. (2018-01-01), Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages Cell Commun. Signal, 16(1):17.
PMID: 29690889
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

X Zhang et al. (2017-01-01), Mesenchymal stromal cells as vehicles of tetravalent bispecific Tandab (CD3/CD19) for the treatment of B cell lymphoma combined with IDO pathway inhibitor D-1-methyl-tryptophan J Hematol Oncol, 10(1):56.
PMID: 28228105
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Hakimzadeh et al. (2017-01-01), Monocytic microRNA profile associated with coronary collateral artery function in chronic total occlusion patients Sci Rep, 7(1):1532.
PMID: 28484274
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E Nagy et al. (2017-01-01), Interferon-? Released by Activated CD8(+) T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves Am. J. Pathol., 0(0).
PMID: 28431214
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MA Schumacher et al. (2017-01-01), ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation Cell Death Dis, 8(2):e2622.
PMID: 28230865
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BF Wang et al. (2017-01-01), Interferon-? induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps Allergy, 0(0).
PMID: 28258963
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MW Tang et al. (2017-01-01), Rheumatoid arthritis and psoriatic arthritis synovial fluid stimulates prolactin production by macrophages J. Leukoc. Biol., 0(0).
PMID: 28642278
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

E El Darzi et al. (2017-01-01), Differential regulation of surface receptor expression, proliferation, and apoptosis in HaCaT cells stimulated with interferon-?, interleukin-4, tumor necrosis factor-?, or muramyl dipeptide Int J Immunopathol Pharmacol, 0(0):3946320177076.
PMID: 28449603
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Arruda-Sil et al. (2017-01-01), Human Neutrophils Produce CCL23 in Response to Various TLR-Agonists and TNF? Front Cell Infect Microbiol, 7(0):176.
PMID: 28553619
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MJ Bae et al. (2017-01-01), Mycobacterium tuberculosis ESAT6 and CPF10 Induce Adenosine Deaminase 2 mRNA Expression in Monocyte-Derived Macrophages Tuberc Respir Dis (Seoul), 80(1):77-82.
PMID: 28119750
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

F Liu et al. (2017-01-01), Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor J. Immunol., 0(0).
PMID: 28947539
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

D Labrousse- et al. (2017-01-01), VHL promotes immune response against renal cell carcinoma via NF-?B-dependent regulation of VCAM-1 J. Cell Biol, 0(0).
PMID: 28235946
Species: Human
Sample Types: Organoids
Applications: Bioassay

RW Jenkins et al. (2017-01-01), Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids Cancer Discov, 0(0).
PMID: 29101162
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Tian et al. (2017-01-01), Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming Nature, 0(0).
PMID: 28371798
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JY Ao et al. (2017-01-01), Colony-stimulating factor 1 receptor blockade inhibits tumor growth by altering the polarization of tumor-associated macrophages in hepatocellular carcinoma Mol. Cancer Ther., 0(0).
PMID: 28572167
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N Starc et al. (2017-01-01), Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency Sci Rep, 7(1):8153.
PMID: 28811575
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

X Wang et al. (2017-01-01), Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions J Extracell Vesicles, 6(1):1314073.
PMID: 28473886
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Qin et al. (2017-01-01), SPI-2/CrmA inhibits IFN-? induction by targeting TBK1/IKK? Sci Rep, 7(1):10495.
PMID: 28874755
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Huang et al. (2017-01-01), Th1high in tumor microenvironment is an indicator of poor prognosis for patients with NSCLC Oncotarget, 8(8):13116-13125.
PMID: 28061450
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AC Tecalco Cr et al. (2017-01-01), Cell type-dependent regulation of free ISG15 levels and ISGylation J Cell Commun Signal, 0(0).
PMID: 28285335
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Zhang et al. (2017-01-01), Curcumin induces apoptosis in human leukemic cell lines through an IFIT2-dependent pathway Cancer Biol. Ther, 0(0):1-8.
PMID: 28071969
Species: Human
Sample Types: Whole Cells
Applications: Bioassay, c

E Redondo-Ca et al. (2017-01-01), Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro Stem Cell Res Ther, 8(1):79.
PMID: 28412968
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JS Ainscough et al. (2017-01-01), Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36? Proc. Natl. Acad. Sci. U.S.A, 114(13):E2748-E2757.
PMID: 28289191
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HC Hsia et al. (2017-01-01), Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding kinase 1 (TBK1) to Restrain STAT3 Activity J. Biol. Chem, 0(0).
PMID: 28188292
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AC Lundell et al. (2017-01-01), IFN type I and II induce BAFF secretion from human decidual stromal cells Sci Rep, 7(0):39904.
PMID: 28057926
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

NN Mehta et al. (2017-01-01), IFN-? and TNF-? synergism may provide a link between psoriasis and inflammatory atherogenesis Sci Rep, 7(1):13831.
PMID: 29062018
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MH van Atteku et al. (2017-01-01), Macrophages confer survival signals via CCR1-dependent translational MCL-1 induction in chronic lymphocytic leukemia Oncogene, 0(0).
PMID: 28192408
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HM Rostam et al. (2017-01-01), Image based Machine Learning for identification of macrophage subsets Sci Rep, 7(1):3521.
PMID: 28615717
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

A Raimondo et al. (2017-01-01), Psoriatic cutaneous inflammation promotes human monocyte differentiation into active osteoclasts, facilitating bone damage Eur. J. Immunol., 0(0).
PMID: 28386999
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Arai et al. (2017-01-01), Salt suppresses IFN? inducible chemokines through the IFN?-JAK1-STAT1 signaling pathway in proximal tubular cells Sci Rep, 7(0):46580.
PMID: 28425456
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Basu et al. (2017-01-01), Conserved structures formed by heterogeneous RNA sequences drive silencing of an inflammation responsive post-transcriptional operon Nucleic Acids Res., 0(0).
PMID: 29069516
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Qin et al. (2017-01-01), Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against Toxoplasma gondii Proc. Natl. Acad. Sci. U.S.A, 0(0).
PMID: 28123064
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Q Wu et al. (2017-01-01), NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy Cell Death Differ., 0(0).
PMID: 28574504
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JD Widdringto et al. (2017-01-01), Mitochondrial DNA depletion induces innate immune dysfunction rescued by interferon-? J. Allergy Clin. Immunol., 0(0).
PMID: 28629747
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MA Terkawi et al. (2017-01-01), Involvement of ?-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum Sci Rep, 7(0):41772.
PMID: 28181499
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Pavesi et al. (2017-01-01), A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors JCI Insight, 2(12).
PMID: 28614795
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

R Bruen et al. (2017-01-01), Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis Cardiovasc Diabetol, 16(1):143.
PMID: 29110715
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-01-01), Procyanidin A2 Modulates IL-4-Induced CCL26 Production in Human Alveolar Epithelial Cells Int J Mol Sci, 17(11).
PMID: 27845745
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-01-01), Prenylated Polyphenols from Clusiaceae and Calophyllaceae with Immunomodulatory Activity on Endothelial Cells PLoS ONE, 11(12):e0167361.
PMID: 27907087
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-01-01), Interferon-? blocks signalling through PDGFR? in human brain pericytes J Neuroinflammation, 13(1):249.
PMID: 27654972
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-01-01), Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic Proc Natl Acad Sci USA, 113(38):10643-10648.
PMID: 27601677
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Robert Sabat (2016-01-01), MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations Mediators Inflamm., 2016(0):4097574.
PMID: 27843200
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

G Karina Chimal-Ram (2016-01-01), Monocyte Differentiation towards Protumor Activity Does Not Correlate with M1 or M2 Phenotypes J Immunol Res, 2016(0):6031486.
PMID: 27376091
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Liu et al. (2016-01-01), Immunomodulation by mesenchymal stem cells in treating human autoimmune disease-associated lung fibrosis Stem Cell Res Ther, 7(1):63.
PMID: 27107963
Species: Human
Sample Types: Cell Culture Supernates
Applications: Bioassay

Martine Schrøder (2016-01-01), CD1c-Expression by Monocytes - Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits PLoS ONE, 11(6):e0157387.
PMID: 27311059
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Guo Z et al. (2016-01-01), Up-Regulation of Human Inducible Nitric Oxide Synthase by p300 Transcriptional Complex. PLoS ONE, 11(1):e0146640.
PMID: 26751080
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Qiyun Zhu (2016-01-01), Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-? Signaling Pathways by Targeting VISA J. Immunol., 0(0).
PMID: 27821666
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kellie N Smith (2016-01-01), Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells MBio, 7(3).
PMID: 27247230
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Susheela Tridandapa (2016-01-01), Interferon-? Promotes Antibody-mediated Fratricide of Acute Myeloid Leukemia Cells J. Biol. Chem., 291(49):25656-25666.
PMID: 27780867
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-01-01), Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells Elife, 5(0).
PMID: 27644592
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SW Jackson et al. (2016-01-01), B cell IFN-? receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6 J Exp Med, 0(0).
PMID: 27069113
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-01-01), PD-1/PD-L1 blockade enhances T cell activity and antitumor efficacy of imatinib in gastrointestinal stromal tumors Clin Cancer Res, 0(0).
PMID: 27470968
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-01-01), MiR-146a modulates macrophage polarization in systemic juvenile idiopathic arthritis by targeting INHBA Mol Immunol, 77(0):205-212.
PMID: 27541693
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-01-01), TLR3 preconditioning enhances the therapeutic efficacy of umbilical cord mesenchymal stem cells in TNBS-induced colitis via the TLR3-Jagged-1-Notch-1 pathway Mucosal Immunol, 0(0).
PMID: 27649928
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-01-01), Programmed death-ligand 1 (PD-L1) characterization of circulating tumor cells (CTCs) in muscle invasive and metastatic bladder cancer patients BMC Cancer, 16(1):744.
PMID: 27658492
Species: Human
Sample Types: Plasma
Applications: Western Blot

(2016-01-01), Identification of a major epitope by anti-interferon-? autoantibodies in patients with mycobacterial disease Nat Med, 0(0).
PMID: 27525523
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mark L Chiu (2016-01-01), Fc engineering approaches to enhance the agonism and effector functions of an anti-OX40 antibody J. Biol. Chem., 0(0).
PMID: 27856634
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Andrea Todisco (2016-01-01), Regulation and function of Bone Morphogenetic Protein signaling in colonic injury and inflammation Am. J. Physiol. Gastrointest. Liver Physiol., 0(0):ajpgi.00169.2.
PMID: 27856416
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nicholas M Plugis (2016-01-01), Thioredoxin-1 Selectively Activates Transglutaminase 2 in the Extracellular Matrix of the Small Intestine: Implications for Celiac Disease J. Biol. Chem, 0(0).
PMID: 28003361
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nagarsheth N et al. (2016-01-01), PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer. Cancer Res, 76(2):275-82.
PMID: 26567139
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Takuya Matsumoto (2016-01-01), Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages Arthritis Res Ther, 18(1):133.
PMID: 27267914
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-01-01), Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype Sci Rep, 6(0):29712.
PMID: 27431276
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zhao Y et al. (2015-01-01), Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate. Eur J Immunol, 45(9):2494-503.
PMID: 25959978
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Herova M et al. (2015-01-01), ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages. J Immunol, 194(5):2330-7.
PMID: 25637017
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Howland S et al. (2015-01-01), Activated Brain Endothelial Cells Cross-Present Malaria Antigen. PLoS Pathog, 11(6):e1004963.
PMID: 26046849
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sugita S et al. (2015-01-01), Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci, 56(2):1051-62.
PMID: 25604685
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Abiko K et al. (2015-01-01), IFN-gamma from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer. Br J Cancer, 112(9):1501-9.
PMID: 25867264
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Singh S et al. (2015-01-01), Granulocyte-macrophage colony stimulatory factor enhances the pro-inflammatory response of interferon-gamma-treated macrophages to Pseudomonas aeruginosa infection. PLoS ONE, 10(2):e0117447.
PMID: 25706389
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rhein B et al. (2015-01-01), Interferon-gamma Inhibits Ebola Virus Infection. PLoS Pathog, 11(11):e1005263.
PMID: 26562011
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Spampinato S et al. (2015-01-01), Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli? PLoS ONE, 10(7):e0133392.
PMID: 26197437
Sundnes O et al. (2015-01-01), Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences. J Invest Dermatol, 135(7):1771-80.
PMID: 25739051
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chiu E et al. (2015-01-01), Identification of a nuclear export sequence in the MHC CIITA. J Immunol, 194(12):6102-11.
PMID: 25948812
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kwofie K et al. (2015-01-01), Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M. Respir Res, 16(0):14.
PMID: 25849622
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Folgiero V et al. (2015-01-01), TIM-3/Gal-9 interaction induces IFNgamma-dependent IDO1 expression in acute myeloid leukemia blast cells. J Hematol Oncol, 8(0):36.
PMID: 25886742
Catanzaro D et al. (2015-01-01), Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage. PLoS ONE, 10(5):e0125375.
PMID: 25955295
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Maleki Vareki S et al. (2015-01-01), IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells. PLoS ONE, 10(11):e0143435.
PMID: 26579709
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kenna T et al. (2015-01-01), Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis. Genes Immun, 16(1):35-42.
PMID: 25354578
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Arnold C et al. (2015-01-01), The activation status of human macrophages presenting antigen determines the efficiency of Th17 responses. Immunobiology, 220(1):10-9.
PMID: 25454489
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Campia I et al. (2015-01-01), An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells. PLoS ONE, 10(5):e0126159.
PMID: 25955018
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Oth et al. (2014-01-01), Monitoring the initiation and kinetics of human dendritic cell-induced polarization of autologous naive CD4+ T cells. PLoS ONE, 9(8):e103725.
PMID: 25144736
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Garcia S et al. (2014-01-01), Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype. PLoS ONE, 9(1):e82088.
PMID: 24404127
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Berri F et al. (2014-01-01), Annexin V incorporated into influenza virus particles inhibits gamma interferon signaling and promotes viral replication. J Virol, 88(19):11215-28.
PMID: 25031344
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MacLeod A et al. (2014-01-01), Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair. J Immunol, 192(12):5695-702.
PMID: 24808367
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cichocki F et al. (2014-01-01), Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency. J Exp Med, 211(6):1079-91.
PMID: 24842371
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ji et al. (2014-01-01), Identification of novel human leukocyte antigen-A*0201-restricted, cytotoxic T lymphocyte epitopes on CD133 for cancer stem cell immunotherapy. Stem Cells Transl Med, 3(3):356-64.
PMID: 24375541
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Yamashita A et al. (2014-01-01), Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage. PLoS ONE, 9(1):e86426.
PMID: 24466087
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Reiner A et al. (2014-01-01), Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189. Int J Mol Sci, 16(1):758-87.
PMID: 25561230
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Voraphani N et al. (2014-01-01), An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma. Mucosal Immunol, 7(5):1175-85.
PMID: 24518246
Species: Human
Sample Types: Plasma
Applications: Bioassay

Fryer et al. (2014-01-01), G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism. J Pharmacol Exp Ther, 348(3):421-31.
PMID: 24399854
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Roy S et al. (2014-01-01), CD14 mediates Toll-like receptor 4 (TLR4) endocytosis and spleen tyrosine kinase (Syk) and interferon regulatory transcription factor 3 (IRF3) activation in epithelial cells and impairs neutrophil infiltration and Pseudomonas aeruginosa killing in vivo. J Biol Chem, 289(2):1174-82.
PMID: 24275652
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Deng B et al. (2014-01-01), Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. PLoS ONE, 9(7):e102362.
PMID: 25036362
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Vermi W et al. (2014-01-01), slanDCs selectively accumulate in carcinoma-draining lymph nodes and marginate metastatic cells. Nat Commun, 5(0):3029.
PMID: 24398631
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fairfax B et al. (2014-01-01), Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression. Science, 343(6175):1246949.
PMID: 24604202
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Jebran A et al. (2014-01-01), Rapid healing of cutaneous leishmaniasis by high-frequency electrocauterization and hydrogel wound care with or without DAC N-055: a randomized controlled phase IIa trial in Kabul. PLoS Negl Trop Dis, 8(2):e2694.
PMID: 24551257
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zhong H et al. (2014-01-01), Hemin controls T cell polarization in sickle cell alloimmunization. J Immunol, 193(1):102-10.
PMID: 24879794
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Milwid et al. (2014-01-01), Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators. Mol Ther, 22(5):999-1007.
PMID: 24496384
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Melhem N et al. (2014-01-01), The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8(+) T cell responses. Virology, 450(0):34-48.
PMID: 24503065
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Uhlenbrock F et al. (2014-01-01), The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway. J Immunol, 193(4):1654-65.
PMID: 25024379
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ren Z et al. (2014-01-01), E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-kappaB modulation. Mol Cancer, 13(0):84.
PMID: 24742333
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

Chiricozzi et al. (2014-01-01), IL-17 induces an expanded range of downstream genes in reconstituted human epidermis model. PLoS ONE, 9(2):e90284.
PMID: 24587313
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Liu Y et al. (2014-01-01), Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis. J Immunol, 192(1):59-72.
PMID: 24323580
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hu M et al. (2014-01-01), TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A, 111(4):1509-14.
PMID: 24434549
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Niedbala W et al. (2014-01-01), Nitric oxide enhances Th9 cell differentiation and airway inflammation. Nat Commun, 5(0):4575.
PMID: 25099390
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lopez-Ramirez M et al. (2014-01-01), MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. FASEB J, 28(6):2551-65.
PMID: 24604078
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Suzuki et al. (2014-01-01), Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. J Biol Chem, 289(8):5330-9.
PMID: 24398680
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Culina S et al. (2014-01-01), No major role for insulin-degrading enzyme in antigen presentation by MHC molecules. PLoS ONE, 9(2):e88365.
PMID: 24516642
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Engstrom A et al. (2014-01-01), Conditioned media from macrophages of M1, but not M2 phenotype, inhibit the proliferation of the colon cancer cell lines HT-29 and CACO-2. Int J Oncol, 44(2):385-92.
PMID: 24296981
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wong et al. (2014-01-01), Eosinophils regulate peripheral B cell numbers in both mice and humans. J Immunol, 192(8):3548-58.
PMID: 24616476
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Valle Oseguera et al. (2014-01-01), cmvIL-10 stimulates the invasive potential of MDA-MB-231 breast cancer cells. PLoS ONE, 9(2):e88708.
PMID: 24520416
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Parlato M et al. (2014-01-01), CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis. J Immunol, 192(5):2449-59.
PMID: 24501201
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

van Wilgenburg et al. (2014-01-01), The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4. PLoS ONE, 9(1):e86071.
PMID: 24465876
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Jansson D et al. (2014-01-01), A role for human brain pericytes in neuroinflammation. J Neuroinflammation, 11(0):104.
PMID: 24920309
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Frazier T et al. (2014-01-01), Human adipose-derived stromal/stem cells induce functional CD4+CD25+FoxP3+CD127- regulatory T cells under low oxygen culture conditions. Stem Cells Dev, 23(9):968-77.
PMID: 24405386
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Shi L et al. (2014-01-01), The SLE transcriptome exhibits evidence of chronic endotoxin exposure and has widespread dysregulation of non-coding and coding RNAs. PLoS ONE, 9(5):e93846.
PMID: 24796678
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Italiani et al. (2014-01-01), Transcriptomic profiling of the development of the inflammatory response in human monocytes in vitro. PLoS ONE, 9(2):e87680.
PMID: 24498352
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Katholnig K et al. (2013-01-01), p38alpha senses environmental stress to control innate immune responses via mechanistic target of rapamycin. J Immunol, 190(4):1519-27.
PMID: 23315073
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Iachininoto M et al. (2013-01-01), Cyclooxygenase-2 (COX-2) inhibition constrains indoleamine 2,3-dioxygenase 1 (IDO1) activity in acute myeloid leukaemia cells. Molecules, 18(9):10132-45.
PMID: 23973990
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dong J et al. (2013-01-01), Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-gamma memory in human CD4(+) T lymphocytes. Eur J Immunol, 43(3):793-804.
PMID: 23255246
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chen P et al. (2013-01-01), Anti-CD70 immunocytokines for exploitation of interferon-gamma-induced RIP1-dependent necrosis in renal cell carcinoma. PLoS ONE, 8(4):e61446.
PMID: 23613854
Species: Human
Sample Types: Plasma
Applications: Bioassay

Rosen L et al. (2013-01-01), Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis. J Immunol, 190(8):3959-66.
PMID: 23509356
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Madonna S et al. (2013-01-01), Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses. Eur J Immunol, 43(7):1883-95.
PMID: 23592500
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hambleton et al. (2013-01-01), STAT2 deficiency and susceptibility to viral illness in humans. Proc Natl Acad Sci U S A, 110(8):3053-8.
PMID: 23391734
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zizzo G et al. (2013-01-01), IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids. J Immunol, 190(10):5237-46.
PMID: 23596310
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Llop-Guevara A et al. (2013-01-01), A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure. PLoS ONE, 9(2):e88714.
PMID: 24551140
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Melo et al. (2013-01-01), The internal architecture of leukocyte lipid body organelles captured by three-dimensional electron microscopy tomography. PLoS ONE, 8(3):e59578.
PMID: 23555714
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bancerek J et al. (2013-01-01), CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity, 38(2):250-62.
PMID: 23352233
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wang et al. (2013-01-01), Differential regulation of interleukin-12 (IL-12)/IL-23 by Tim-3 drives T(H)17 cell development during hepatitis C virus infection. J Virol, 87(8):4372-83.
PMID: 23388728
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Xia et al. (2013-01-01), Inhibition of hepatitis B virus gene expression and replication by ribonuclease P. Mol Ther, 21(5):995-1003.
PMID: 23481322
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Johnston A et al. (2013-01-01), Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis. Hum Mol Genet, 22(9):1807-15.
PMID: 23376980
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pennino D et al. (2013-01-01), IL-22 suppresses IFN-gamma-mediated lung inflammation in asthmatic patients. J Allergy Clin Immunol, 131(2):562-70.
PMID: 23174657
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Yoneno K et al. (2013-01-01), TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease. Immunology, 139(1):19-29.
PMID: 23566200
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kothari H et al. (2012-01-01), Mycobacterium tuberculosis infection and tissue factor expression in macrophages. PLoS ONE, 7(9):e45700.
PMID: 23029190
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zizzo G et al. (2012-01-01), Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction. J Immunol, 189(7):3508-20.
PMID: 22942426
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zhang J et al. (2012-01-01), Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production. PLoS ONE, 7(4):e34965.
PMID: 22529962
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bonanno G et al. (2012-01-01), Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma. J Transl Med, 10(0):247.
PMID: 23232072
Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

(2012-01-01), CD34-derived dendritic cells transfected ex vivo with HIV-Gag mRNA induce polyfunctional T-cell responses in nonhuman primates. Eur. J. Immunol., 42(8):2019-30.
PMID: 22585548
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kayali AG et al. (2012-01-01), The SDF-1ÃŽÂ±/CXCR4 Axis is Required for Proliferation and Maturation of Human Fetal Pancreatic Endocrine Progenitor Cells. PLoS ONE, 7(6):e38721.
PMID: 22761699
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2012-01-01), Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis. J. Exp. Med., 209(11):2033-47.
PMID: 23071254
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kuriyama T et al. (2012-01-01), Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis. Blood, 120(19):4058-67.
PMID: 22990013
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2012-01-01), Epigenetic modulation enhances the therapeutic effect of anti-IL-13R alpha2 antibody in human mesothelioma xenografts. Clin. Cancer Res., 17(9):2819-29.
PMID: 21357681
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Graham LM et al. (2012-01-01), The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase. J. Biol. Chem., 287(31):25964-74.
PMID: 22689578
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2012-01-01), Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells. Gene Ther, 19(10):1035-40.
PMID: 22071967
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2012-01-01), Regulation of IL-33 expression by IFN-gamma and tumor necrosis factor-alpha in normal human epidermal keratinocytes. J. Invest. Dermatol., 132(11):2593-600.
PMID: 22673732
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Shin HS et al. (2011-01-01), Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo. J. Immunol., 186(2):1119-30.
PMID: 21169547
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Joubert P et al. (2011-01-01), Expression and regulation of CCL15 by human airway smooth muscle cells. Clin. Exp. Allergy, 42(1):85-94.
PMID: 22092970
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hasegawa H et al. (2011-01-01), Native IL-32 is released from intestinal epithelial cells via a non-classical secretory pathway as a membrane-associated protein. Cytokine, 53(1):74-83.
PMID: 20926308
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gibbings S et al. (2011-01-01), Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-gamma sumoylation, and HIF-1alpha. J. Biol. Chem., 286(2):961-75.
PMID: 21059659
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Knoblach T et al. (2011-01-01), Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma. PLoS Pathog., 7(4):e1002016.
PMID: 21533215
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Carrier Y et al. (2011-01-01), Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis. J. Invest. Dermatol., 131(12):2428-37.
PMID: 21881584
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Von Bubnoff D et al. (2011-01-01), Identification of IDO-positive and IDO-negative human dendritic cells after activation by various proinflammatory stimuli. J. Immunol., 186(12):6701-9.
PMID: 21543643
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gudjonsson JE et al. (2010-01-01), Evidence for altered Wnt signaling in psoriatic skin. J. Invest. Dermatol., 130(7):1849-59.
PMID: 20376066
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ghirelli C et al. (2010-01-01), Systematic cytokine receptor profiling reveals GM-CSF as a novel TLR-independent activator of human plasmacytoid predendritic cells. Blood, 115(24):5037-40.
PMID: 20382843
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pennino D et al. (2010-01-01), IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes. J. Immunol., 184(9):4880-8.
PMID: 20357258
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mengshol JA et al. (2010-01-01), A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS ONE, 5(3):e9504.
PMID: 20209097
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zhang G et al. (2010-01-01), B7-h3 augments the inflammatory response and is associated with human sepsis. J. Immunol., 185(6):3677-84.
PMID: 20696859
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Morishige T et al. (2010-01-01), Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy. Biomaterials, 31(12):3357-63.
PMID: 20117833
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kotarsky K et al. (2010-01-01), A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa. Mucosal Immunol, 3(1):40-8.
PMID: 19812544
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nishida A et al. (2010-01-01), Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts. Gut, 59(4):531-41.
PMID: 19996325
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ghigo E et al. (2010-01-01), IL-16 promotes T. whipplei replication by inhibiting phagosome conversion and modulating macrophage activation. PLoS ONE, 5(10):e13561.
PMID: 21042409
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Semiramoth N et al. (2009-01-01), Escherichia coli type 1 pili trigger late IL-8 production by neutrophil-like differentiated PLB-985 cells through a Src family kinase- and MAPK-dependent mechanism. J. Leukoc. Biol., 85(2):310-21.
PMID: 19015376
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Witte K et al. (2009-01-01), Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun., 10(8):702-14.
PMID: 19798076
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lee WI et al. (2009-01-01), Immunologic analysis of HIV-uninfected Taiwanese children with BCG-induced disease. J. Clin. Immunol., 29(3):319-29.
PMID: 19089604
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Albanesi C et al. (2009-01-01), Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J. Exp. Med., 206(1):249-58.
PMID: 19114666
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Christophi GP et al. (2009-01-01), Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1. Clin. Immunol., 133(1):27-44.
PMID: 19559654
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wolk K et al. (2009-01-01), The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Eur. J. Immunol., 39(12):3570-81.
PMID: 19830738
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kinoshita H et al. (2009-01-01), Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J. Allergy Clin. Immunol., 123(1):179-86.
PMID: 19056108
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Eid RE et al. (2009-01-01), Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation, 119(10):1424-32.
PMID: 19255340
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hirosako S et al. (2009-01-01), Human bronchial intraepithelial T cells produce interferon-gamma and stimulate epithelial cells. Clin. Exp. Immunol., 155(2):266-74.
PMID: 19040600
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ma P et al. (2009-01-01), Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines. Invest. Ophthalmol. Vis. Sci., 50(6):2702-9.
PMID: 19151401
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nishida A et al. (2009-01-01), Interleukin-32 expression in the pancreas. J. Biol. Chem., 284(26):17868-76.
PMID: 19386602
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rahmoun M et al. (2009-01-01), Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils. J. Invest. Dermatol., 129(3):671-81.
PMID: 18843289
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Schwinn N et al. (2009-01-01), Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells. Int. J. Cancer, 124(7):1594-604.
PMID: 19089914
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MacRedmond R et al. (2009-01-01), Erythropoietin inhibits respiratory epithelial cell apoptosis in a model of acute lung injury. Eur. Respir. J., 33(6):1403-14.
PMID: 19164355
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hao Q et al. (2009-01-01), Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells. Am. J. Physiol., Cell Physiol., 296(4):C821-7.
PMID: 19176759
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Liu TY et al. (2008-01-01), Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells. Eur. J. Immunol., 38(4):1012-23.
PMID: 18350544
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dambacher J et al. (2008-01-01), The role of interleukin-22 in hepatitis C virus infection. Cytokine, 41(3):209-16.
PMID: 18191408
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hama S et al. (2008-01-01), Nitric oxide attenuates vascular endothelial cadherin-mediated vascular integrity in human chronic inflammation. Clin. Exp. Immunol., 154(3):384-90.
PMID: 19037921
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Montecucco F et al. (2008-01-01), C-reactive protein (CRP) induces chemokine secretion via CD11b/ICAM-1 interaction in human adherent monocytes. J. Leukoc. Biol., 84(4):1109-19.
PMID: 18591415
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Joubert P et al. (2008-01-01), Expression and regulation of CCR1 by airway smooth muscle cells in asthma. J. Immunol., 180(2):1268-75.
PMID: 18178867
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wente MN et al. (2008-01-01), Expression and potential function of the CXC chemokine CXCL16 in pancreatic ductal adenocarcinoma. Int. J. Oncol., 33(2):297-308.
PMID: 18636150
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wolk K et al. (2008-01-01), Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes. J. Leukoc. Biol., 83(5):1181-93.
PMID: 18281438
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Guttman-Yassky E et al. (2008-01-01), Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis. J. Immunol., 181(10):7420-7.
PMID: 18981165
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Biancotto A et al. (2008-01-01), Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 24(3):453-62.
PMID: 18327985
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kato A et al. (2008-01-01), Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J. Allergy Clin. Immunol., 121(6):1385-92, 1392.
PMID: 18410958
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Facco M et al. (2007-01-01), Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis. J. Leukoc. Biol., 82(4):946-55.
PMID: 17615381
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wosik K et al. (2007-01-01), Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis. J. Neurosci., 27(34):9032-42.
PMID: 17715340
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Qui H et al. (2007-01-01), Fluorescence single-molecule counting assays for high-sensitivity detection of cytokines and chemokines. Clin. Chem., 53(11):2010-2.
PMID: 18030696
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Parmley LA et al. (2007-01-01), Alpha-4/beta-1 and alpha-L/beta-2 integrins mediate cytokine induced lung leukocyte-epithelial adhesion and injury. Br. J. Pharmacol., 152(6):915-29.
PMID: 17828290
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dame TM et al. (2007-01-01), IFN-gamma alters the response of Borrelia burgdorferi-activated endothelium to favor chronic inflammation. J. Immunol., 178(2):1172-9.
PMID: 17202382
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Biancotto A et al. (2007-01-01), Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 109(10):4272-9.
PMID: 17289812
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Oates JC et al. (2007-01-01), Association of reactive oxygen and nitrogen intermediate and complement levels with apoptosis of peripheral blood mononuclear cells in lupus patients. Arthritis Rheum., 56(11):3738-47.
PMID: 17968874
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sa SM et al. (2007-01-01), The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J. Immunol., 178(4):2229-40.
PMID: 17277128
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kanda N et al. (2007-01-01), Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes. Endocrinology, 148(5):2317-25.
PMID: 17255201
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Watanabe K et al. (2007-01-01), Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. J. Biol. Chem., 282(43):31643-55.
PMID: 17720976
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dambacher J et al. (2007-01-01), Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease. Gut, 56(9):1257-65.
PMID: 17449633
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nagineni CN et al. (2007-01-01), Interferon-gamma differentially regulates TGF-beta1 and TGF-beta2 expression in human retinal pigment epithelial cells through JAK-STAT pathway. J. Cell. Physiol., 210(1):192-200.
PMID: 17013806
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hundhausen C et al. (2007-01-01), Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes. J. Immunol., 178(12):8064-72.
PMID: 17548644
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Shioya M et al. (2007-01-01), Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease. Clin. Exp. Immunol., 149(3):480-6.
PMID: 17590175
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hajishengallis G et al. (2007-01-01), Complement receptor 3 blockade promotes IL-12-Mediated Clearance of Porphyromonas gingivalis and Negates Its Virulence In Vivo. J. Immunol., 179(4):2359-67.
PMID: 17675497
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kato A et al. (2007-01-01), TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J. Immunol., 179(2):1080-7.
PMID: 17617600
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wan B et al. (2006-01-01), Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. J. Immunol., 177(12):8844-50.
PMID: 17142787
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Johnson LA et al. (2006-01-01), An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J. Exp. Med., 203(12):2763-77.
PMID: 17116732
Species: Hamster
Sample Types: Whole Cells
Applications: Bioassay

Petropavlovskaia M et al. (2006-01-01), Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression. J. Endocrinol., 191(1):65-81.
PMID: 17065390
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Gounni Abdelilah S et al. (2006-01-01), Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin. Immunol., 120(2):220-31.
PMID: 16782408
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sugaya M et al. (2006-01-01), Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes. J. Immunol., 177(11):7665-72.
PMID: 17114436
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mesturini R et al. (2006-01-01), ICOS cooperates with CD28, IL-2, and IFN-gamma and modulates activation of human naive CD4+ T cells. Eur. J. Immunol., 36(10):2601-12.
PMID: 17013990
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wolk K et al. (2006-01-01), IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol., 36(5):1309-23.
PMID: 16619290
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ebert EC et al. (2006-01-01), Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell. Immunol., 241(1):7-13.
PMID: 16914126
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zhang Y et al. (2006-01-01), Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation. J. Neurosci., 26(47):12174-85.
PMID: 17122042
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Skoberne M et al. (2006-01-01), The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function. Blood, 108(3):947-55.
PMID: 16614246
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cho ML et al. (2006-01-01), Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression. Immunol. Lett., 105(2):159-66.
PMID: 16564576
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Peng H et al. (2006-01-01), HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta. Glia, 54(6):619-29.
PMID: 16944452
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Meller S et al. (2005-01-01), Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus. Arthritis Rheum., 52(5):1504-16.
PMID: 15880822
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kermarrec N et al. (2005-01-01), Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage. Crit. Care Med., 33(6):1359-64.
PMID: 15942356
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Scapini P et al. (2005-01-01), Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases. Blood, 105(2):830-7.
PMID: 15358625
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dulos J et al. (2005-01-01), CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum., 52(3):770-8.
PMID: 15751070
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ameredes BT et al. (2005-01-01), Modulation of GM-CSF release by enantiomers of beta-agonists in human airway smooth muscle. J. Allergy Clin. Immunol., 116(1):65-72.
PMID: 15990776
Best SM et al. (2005-01-01), Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist. J. Virol., 79(20):12828-39.
PMID: 16188985
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wang P et al. (2004-01-01), Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor. Biochem. J., 380(0):425-33.
PMID: 14992689
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wolk K et al. (2004-01-01), IL-22 increases the innate immunity of tissues. Immunity, 21(2):241-54.
PMID: 15308104
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Radstake TR et al. (2004-01-01), Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum., 50(12):3856-65.
PMID: 15593217
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Oynebraten I et al. (2004-01-01), Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments. Blood, 104(2):314-20.
PMID: 15044249
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Copeland S et al. (2004-01-01), Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J. Immunol. Methods, 284(1):99-106.
PMID: 14736420
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ryan LA et al. (2004-01-01), TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: links to HIV-1-associated dementia. J. Neuroimmunol., 148(1):127-39.
PMID: 14975593
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gibot S et al. (2004-01-01), A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J. Exp. Med., 200(11):1419-26.
PMID: 15557347
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pivarcsi A et al. (2004-01-01), CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. J. Immunol., 173(9):5810-7.
PMID: 15494534
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wen FQ et al. (2004-01-01), Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads. Am. J. Respir. Cell Mol. Biol., 30(6):816-22.
PMID: 14722222
Species: Human

Applications: Binding Assay

Uchida K et al. (2004-01-01), High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis. Blood, 103(3):1089-98.
PMID: 14512323
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kao CY et al. (2004-01-01), IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol., 173(5):3482-91.
PMID: 15322213
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Groh V et al. (2003-01-01), Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc. Natl. Acad. Sci. U.S.A., 100(16):9452-7.
PMID: 12878725
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Borchmann P et al. (2003-01-01), The human anti-CD30 antibody 5F11 shows in vitro and in vivo activity against malignant lymphoma. Blood, 102(10):3737-42.
PMID: 12881320
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Durali D et al. (2003-01-01), In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment. Blood, 102(12):4084-9.
PMID: 12893768
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

McLoughlin RM et al. (2003-01-01), Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J. Clin. Invest., 112(4):598-607.
PMID: 12925700
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wang XB et al. (2002-01-01), Expression of CTLA-4 by human monocytes. Scand. J. Immunol., 55(1):53-60.
PMID: 11841692
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mirani M et al. (2002-01-01), HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection. J. Immunol., 169(11):6361-8.
PMID: 12444143
Species: Human

Applications: Bioassay

Barcena A et al. (1996-01-01), Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver. Blood, 88(6):2013-25.
PMID: 8822920
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wang R et al. (), Natural killer cell-produced IFN-gamma and TNF-alpha induce target cell cytolysis through up-regulation of ICAM-1. J Leukoc Bio91(2):299-309.
PMID: 22045868
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Babelova A et al. (), Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Che284(36):24035-48.
PMID: 19605353
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bsat M et al. (), The Conversion of Human Tissue-Like Inflammatory Monocytes Into Macrophages. Curr Proto1(3):e74.
PMID: 33705607

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Customer Reviews for Recombinant Human IFN-gamma Protein (22)

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Recombinant Human IFN-gamma Protein

Name: Anonymous

Application: Flow

Verified Customer | Posted 06/24/2022

Black -> HLA-E surface expression in T cellsGrey -> HLA-E surface expression in T cells upon IFNg stimulation (12h)
Recombinant Human IFN-gamma Protein

Name: Anonymous

Application: In vitro bioactivity in cell culture

Reason for Rating: Comparing gene expression responses by qPCR after IFNg treatment in immune cell subsets

Verified Customer | Posted 06/24/2022

More than a hundred-fold increase for a given target gene in immune cells stimulated with IFNg for 6h compared to controls (for basal level).
Recombinant Human IFN-gamma Protein

Name: Anonymous

Reason for Rating: Used for successfully stimulating human PBMCs.

Verified Customer | Posted 06/24/2022

Lane 1: PBMCs, unstimulatedLane 2: PBMCs, stimulated with IFNg for 6hLane 3: PBMCs, stimulated with IFNg for 24hTarget: HLA detection
Recombinant Human IFN-gamma Protein

Name: Anonymous

Application: In vitro bioactivity in cell culture

Verified Customer | Posted 05/21/2021
Recombinant Human IFN-gamma Protein

Name: Marija Pieper

Application: Apoptosis assay

Verified Customer | Posted 03/11/2021
Recombinant Human IFN-gamma Protein

Name: Anonymous

Verified Customer | Posted 12/18/2020
Recombinant Human IFN-gamma Protein

Name: Anonymous

Application: Stem/Immune cell maintenance or differentiation

Reason for Rating: Gave consistent M1-like macrophage differentiation of human PBMCs

Verified Customer | Posted 11/20/2020
Recombinant Human IFN-gamma Protein

Name: Anonymous

Application: In vitro bioactivity in cell culture

Reason for Rating: Easy to solubilize

Verified Customer | Posted 10/16/2020

Used the to stimulate ex vivo skin culture
Recombinant Human IFN-gamma Protein

Name: Anonymous

Application: In vitro bioactivity in cell culture

Verified Customer | Posted 10/09/2020

HCT-116 cells were treated with hr-IFN-gamma for 24 hours and intracellular IDO-1 expression was measured.
Recombinant Human IFN-gamma Protein

Name: Anonymous

Application: In vitro bioactivity in cell culture

Verified Customer | Posted 06/08/2020
Recombinant Human IFN-gamma Protein

Name: Anonymous

Application: In vitro bioactivity in cell culture

Verified Customer | Posted 06/06/2020
Recombinant Human IFN-gamma Protein

Name: Anonymous

Application: CellProlif

Verified Customer | Posted 07/26/2019
Name: Anonymous

Application: In vitro bioactivity in cell culture

Reason for Rating: Consistent results when used for in vitro cell culture

Verified Customer | Posted 07/25/2019

CD38 transcript levels measured by qPCR after 24 hours treatment with 10 ng/mL IFN-g in MV-4-11 cells
Recombinant Human IFN-gamma Protein

Name: Anonymous

Application: In vitro bioactivity in cell culture

Reason for Rating: The expression of HLA-DR increased with MDAMB231 cells incubated with 1000 IU mL–1 IFN-gamma for 72 h

Verified Customer | Posted 06/09/2019
Name: Mehdi Alavi

Application: Enzymatic activity in vitro

Verified Customer | Posted 03/19/2019
Recombinant Human IFN-gamma Protein

Name: Anonymous

Application: CellProlif

Reason for Rating: HT-29 Cell lines were treated with 100 U/ml IFN gamma, after which HLA-DR expression was examined by flow cytometer

Verified Customer | Posted 11/16/2018
Name: Anonymous

Application: In vitro bioactivity in cell culture

Verified Customer | Posted 10/08/2018
Name: Pia Muyot

Verified Customer | Posted 04/26/2017
Recombinant Human IFN-gamma Protein

Name: Anonymous

Application: In vitro bioactivity in cell culture

Reason for Rating: The IFN-g was excellent in stimulating whole blood.

Verified Customer | Posted 07/21/2016

IFN-g was used to stimulate whole blood. 100ng/mL final concentration was used in 1mL whole blood for 15 minutes at 37C. The cells were fixed and stored in -80C until further analysis on CyTOF
Recombinant Human IFN-gamma Protein

Name: Adam Guess

Application: In vivo study

Verified Customer | Posted 07/13/2016

IFN-gamma treatment (solid line) induces HLA-DR expression in cultured MSC as compared to control cells (filled histogram).
Recombinant Human IFN-gamma Protein

Name: shu wang

Application: In vitro bioactivity in cell culture

Verified Customer | Posted 05/31/2016
Recombinant Human IFN-gamma Protein

Name: SOjan Abraham

Application: In vitro bioactivity in cell culture

Verified Customer | Posted 01/21/2016

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FAQs for Recombinant Human IFN-gamma Protein

Why does Recombinant Human IFN-gamma protein, Catalog # 285-IF, have the amio acid substitution R160Q?

The sequence of R&D Systems' rhIFN-gamma, Catalog # 285-IF, is based on the the following publication in Nature:[https://www.ncbi.nlm.nih.gov/pubmed/?term=Gray+1982+503] Note that in figure 3, the article describes a Gln (Q) in position 160.

Recombinant Human IFN-gamma Protein

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Carrier Free

285-IF

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285-IF/CF

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Background: IFN-gamma

Citations for Recombinant Human IFN-gamma Protein (417)

Customer Reviews for Recombinant Human IFN-gamma Protein (22)

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Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

Recombinant Human IFN-gamma Protein

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