Recombinant Human IFN-alpha H2 (alpha 14) Protein

Catalog # 11145-1 | R&D Systems, Inc. a Bio-Techne Brand
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Key Product Details

Accession #

X02959

Source

E. coli

Conjugate

Unconjugated

Applications

Bioactivity

Product Specifications

Source

E. coli-derived human IFN-alpha H2 protein

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.

Endotoxin Level

<1.0 EU per 1 μg of the protein by the LAL method.

Predicted Molecular Mass

19.7 kDa

Activity

Interferon was titrated with the use of the cytopathic effect inhibition assay as listed:

Bovine (MDBK/VSV) – performed as described [Rubinstein, et al. (1981) J. Virol. 37(2):755]. The EC50 for interferon in this assay is ~5 U/ml. Lot Activity was derived from multiple determinations in the above assay.

Human (A549/EMCV) – performed as described [Budd, et al. (1985) Canc. Chem. Pharm. 12:39]. The EC50 for interferon in this assay is ~1 U/ml.

Formulation, Preparation and Storage

11145-1
Formulation Phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: IFN-alpha H2/IFNA14

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Long Name

Interferon alpha H2

Alternate Names

IFN-alphaH, IFNA14, IFNalpha H2, LEIF2H

Entrez Gene IDs

3448 (Human); 404549 (Mouse)

Gene Symbol

IFNA14

UniProt

X02959

Product Documents for Recombinant Human IFN-alpha H2 (alpha 14) Protein

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Recombinant Human IFN-alpha H2 (alpha 14) Protein

For research use only

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