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Recombinant Human Dopa Decarboxylase/DDC Protein, CF

Catalog # 3564-DC | R&D Systems, Inc. a Bio-Techne Brand
Catalog #
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Key Product Details

Accession #


Sf 21 (baculovirus)




Enzyme Activity

Product Specifications


Spodoptera frugiperda, Sf 21 (baculovirus)-derived human Dopa Decarboxylase/DDC protein
Met1-Glu480, with a C-terminal 6-His tag


>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Endotoxin Level

<1.0 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

No result obtained

Predicted Molecular Mass

55 kDa


55 kDa, reducing conditions


Measured by its ability to convert the substrate 3, 4-dihydroxy L-phenylalanine (L-Dopa) to 3, 4-dihydroxyphenylethylamine (dopamine). The dopamine product is measured by its absorbance at 340 nm after derivatization with trinitrobenzene sulfonic acid. Sherald, F. et al. (1973) Anal. Biochem. 56:300.
The specific activity is >1500 pmol/min/µg, as measured under the described conditions.

Formulation, Preparation and Storage

Formulation Supplied as a 0.2 μm filtered solution in MES, NaCl and DTT.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.

Background: Dopa Decarboxylase/DDC

Dopa Decarboxylase (DDC), also known as aromatic amino acid decarboxylase, is a group II decarboxylase (1). The enzyme catalyzes the decarboxylation of aromatic L-amino acids to produce the corresponding amines. DDC produces the neurotransmitters dopamine and serotonin from L-Dopa and L-5-hydroxytryptophan, respectively. The inhibition of DDC could be used for the treatment of schizophrenia and Parkinson's disease (2).


  1. Sandmeier, E. et al. (1994) Eur. J. Biochem. 221:997.
  2. Bertoldi, M. et al. (1996) J. Biol. Chem. 271:23954.

Alternate Names


Entrez Gene IDs

1644 (Human)

Gene Symbol



Product Documents for Recombinant Human Dopa Decarboxylase/DDC Protein, CF

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Recombinant Human Dopa Decarboxylase/DDC Protein, CF

For research use only

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