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Recombinant Human CD38 Protein, CF
Catalog # 2404-AC | R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Product Specifications
Source
Mouse myeloma cell line, NS0-derived human CD38 protein
Val43-Ile300, with a C-terminal 6-His tag
Val43-Ile300, with a C-terminal 6-His tag
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
N-terminal Sequence Analysis
Val43
Predicted Molecular Mass
31 kDa
SDS-PAGE
43 kDa, reducing conditions
Activity
Measured by its ability to convert the substrate nicotinamide guanine dinucleotide (NGD+) to cyclic GDP-ribose. Graeff, R.M. et al. (1994) J. Biol. Chem. 269:30260.
The specific activity is >2,500 pmol/min/µg, as measured under the described conditions.
The specific activity is >2,500 pmol/min/µg, as measured under the described conditions.
Formulation, Preparation and Storage
2404-AC
| Formulation | Supplied as a 0.2 μm filtered solution in MES and NaCl. |
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Background: CD38
CD38, also known as ADP-ribosyl cyclase, is a Type II integral membrane protein. The enzyme is able to transform NAD(P)+ into three different products with calcium mobilizing ability, cyclic ADP-ribose, NAADP+, and ADP-ribose (1). CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells (2, 3). Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells (4, 5).
References
- Schuber, F. and F.E. Lund (2004) Curr. Mol. Med. 4:249.
- Jackson, D.G. and J.I. Bell (1990) J. Immunol. 144:2811.
- Sun, L. et al. (1999) J. Cell Biol. 146:1161.
- Partida-Sanchez, S. et al. (2001) Nature Med. 7:1209.
- Kato, I. et al. (1995) J. Biol. Chem. 270:30045.
Long Name
Cluster of Differentiation 38
Alternate Names
ADP-ribosyl Cyclase, CD38, Cyclic ADP-ribose Hydrolase
Gene Symbol
CD38
UniProt
Product Documents for Recombinant Human CD38 Protein, CF
Product Specific Notices for Recombinant Human CD38 Protein, CF
For research use only
Citations for Recombinant Human CD38 Protein, CF (3)
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Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human CD38 Protein, CF include:
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Species: Human
Sample Types: Recombinant Protein
Applications: BioassayK Yaku et al. (2021-11-19), BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities Nature Communications, 2021-112(1):6767.
PMID: 34799586 -
Species: Mouse
Sample Types: Plasma
Applications: ELISA CaptureEY Wang et al. (2021-02-01), Diverse Functional Autoantibodies in Patients with COVID-19 medRxiv : the preprint server for health sciences, 2021-00(0).
PMID: 33330894 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayEscande et al. (2012-11-19), Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes, 2012-162(4):1084-93.
PMID: 23172919
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