Recombinant Human ALK-7 Fc Chimera Protein, CF

R&D Systems, part of Bio-Techne | Catalog # 11735-A7

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11735-A7-100
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Key Product Details

Source

CHO

Structure / Form

Disulfide-linked homodimer

Conjugate

Unconjugated

Applications

Bioactivity

View all ALK-7 Proteins and Enzymes »

Product Specifications

Source

Chinese Hamster Ovary cell line, CHO-derived human ALK-7 protein
Human ACVR1C
(Leu26-Glu113)
Accession # P24394.1		 IEGRMD Human IgG1
(Pro100-Lys330)
N-terminus C-terminus

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Leu26

Predicted Molecular Mass

36 kDa

SDS-PAGE

51-62 kDa, under reducing conditions

Activity

Bioassay data are not available.

Formulation, Preparation and Storage

11735-A7
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Reconstitution Reconstitute at 250 μg/mL in water.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ALK-7

Transforming growth Factor beta (TGF-beta) superfamily ligands exert their biological activities via binding to heteromeric receptor complexes of two types (I and II) of serine/threonine kinases. Type II receptors are constitutively active kinases that phosphorylate type I receptors upon ligand binding. In turn, activated type I kinases phosphorylate downstream signaling molecules including the various smads. Transmembrane proteoglycans, including the type III receptor (betaglycan) and endoglin, can bind and present some of the TGF-beta superfamily ligands to type I and II receptor complexes and enhance their cellular responses. Seven type I receptors (also termed activin receptor like kinase (ALK)) and five type II receptors have been isolated from mammals. ALK -2, -3, -4, -5, and -6 are also known as Activin R1A, BMPR-1A, Activin R1B, TGF-beta R1, and BMPR-1B, respectively, reflecting their ligand preferences. ALK-7 is also known as Activin receptor type-1C, ACTR-1C, and ACVR1C. It shares with other type I receptors a cysteine-rich domain with conserved cysteine spacing in the extracellular region, and a glycine and serine rich domain (the GS domain) preceding the kinase domain. It is primarily expressed in the central nervous system, pancreatic islets, and adipose tissue. ALK-7 known ligands, such as Nodal, Activin B, and growth differentiation factor (GDF), can activate Smads and other signaling pathways which regulate cell proliferation, differentiation, and apoptosis in various cells. It has also been shown that orphan ligand, Activin C, signals through activin receptor-like kinase 7. Meanwhile, in mature murine adipocytes, Activin E invoked a SMAD2/3 response via ALK7, like Activin C.

References

  1. ten Dijke, P. et al. (1993) Oncogene 8:2879.
  2. ten Dijke, P. et al. (1994) Science 264:101.
  3. Ryden, M. et al. (1996) J. Biol. Chem. 271:30603.
  4. Roberts, H.J. et al. (2003) Biol Reprod 68:1719-1726.
  5. Goebel, E. et al. (2022) eLife 11:e78197.
  6. Vestal, K.A. et al. (2024) Biochem. J. 481:547-564.

Long Name

Activin Receptor-like Kinase 7

Alternate Names

Activin RIC, ACVR1C, ACVRLK7, ALK7

Entrez Gene IDs

130399 (Human); 245921 (Rat)

Gene Symbol

ACVR1C

Additional ALK-7 Products

Product Documents for Recombinant Human ALK-7 Fc Chimera Protein, CF

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human ALK-7 Fc Chimera Protein, CF

For research use only

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