Recombinant Human PTTG1 His Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-30200

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NBP1-30200
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Key Product Details

Source

E. coli

Tag

His

Conjugate

Unconjugated

Applications

SDS-PAGE

View all PTTG1 Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-202 of Human Securin

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MATLIYVDKE NGEPGTRVVA KDGLKLGSGP SIKALDGRSQ VSTPRFGKTF DAPPALPKAT RKALGTVNRA TEKSVKTKGP LKQKQPSFSA KKMTEKTVKA KSSVPASDDA YPEIEKFFPF NPLDFESFDL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPSPVKMP SPPWESNLLQ SPSSILSTLD VELPPVCCDI DI

Purity

>90%, by SDS-PAGE

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Predicted Molecular Mass

24.1 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human PTTG1 His Protein

SDS-PAGE: Recombinant Human PTTG1 His Protein [NBP1-30200]

SDS-PAGE: Recombinant Human PTTG1 His Protein [NBP1-30200]

SDS-Page: Securin Protein [NBP1-30200] - PTTG1, 24.1 kDa (222aa), confirmed by MALDI-TOF with a purity of 80% by SDS - PAGE

Formulation, Preparation and Storage

NBP1-30200
Formulation 20 mM Tris-HCl buffer (pH8.0), 0.1 M NaCl, 20% glycerol, 1 mM EDTA, 0.1 mM PMSF
Preservative No Preservative
Concentration 0.5 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PTTG1

PTTG1, also known as Securin, is primarily involved in the regulation of sister chromatid separation during cell division. It has two identified roles; the first one is to help the transport of separase(cysteine protease) to the nucleus and the second role is to inhibit the catalytic activity of separase. It is ubiquitinated by the Anaphase Promoting Complex (APC), and then degraded by the Proteasome, releasing separase. Recombinant PTTG1 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Alternate Names

EAP1MGC126883, Esp1-associated protein, ESP1-associated protein 1, hPTTG, pituitary tumor-transforming 1, Pituitary tumor-transforming gene 1 protein, PTTGMGC138276, securin, Tumor-transforming protein 1, TUTR1HPTTG

Gene Symbol

PTTG1

Additional PTTG1 Products

Product Documents for Recombinant Human PTTG1 His Protein

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human PTTG1 His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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