Recombinant Human CXCL17/VCC-1 Protein

Name: Recombinant Human CXCL17/VCC-1 Protein
Brand: Novus Biologicals
SKU: NBP2-35133

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-35133

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Product Specifications
Scientific Data
Preparation & Storage
Background
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Key Product Details

Source

E. coli

Accession #

Q6UXB2

Conjugate

Unconjugated

Applications

Bioactivity, SDS-PAGE

View all CXCL17/VCC-1 Proteins and Enzymes »

Product Specifications

Description

A single non-glycosylated polypeptide chain containing 98 amino acids corresponding to CXCL17/VCC-1 Source: E. coli

Uniprot ID: Q6UXB2

Amino Acid Sequence: SSLNPGVARG HRDRGQASRR WLQEGGQECE CKDWFLRAPR RKFMTVSGLP KKQCPCDHFK GNVKKTRHQR HHRKPNKHSR ACQQFLKQCQ LRSFALPL

Purity

>95%, by SDS-PAGE and HPLC

Endotoxin Level

Less than 0.1 EU/ug of CXCL17/VCC-1 as determined by LAL method.

Predicted Molecular Mass

11.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Activity

CXCL17 protein is fully biologically active when compared to standard. The ED50 as determined by its ability to induce VEGF expression using murine endothelial cells is less than 5.0 ug/ml, corresponding to a specific activity of > 200 IU/mg.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human CXCL17/VCC-1 Protein

SDS-PAGE: Recombinant Human CXCL17/VCC-1 Protein [NBP2-35133]

SDS-Page: Human CXCL17/VCC-1 Protein [NBP2-35133]

Formulation, Preparation and Storage

NBP2-35133

Formulation	Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4, with 3 % Trehalose.
Preservative	Trehalose
Concentration	Lyoph
Reconstitution	Recommended to centrifuge prior to opening. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/mL.
Format	Carrier-Free
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -20 to -70C as supplied. After reconstitution, store at 2 to 8C for 1 month and at -20 to -70C for long term storage. Avoid repeated freeze-thaw cycles.

Background: CXCL17/VCC-1

CXCL17 also named dendritic cell and monocyte chemokine-like protein (DMC) and VEGF co-regulated chemokine 1 (VCC-1), is a small cytokine belonging to the CXC chemokine family. It is constitutively expressed in the lung and can be detected in trachea, stomach and skeletal muscle. CXCL17 attracts dendritic cells and monocytes and is regulated in tumors. It may be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues and may play a role in the innate defense against infections. Mature human CXCL17 shares 73 %, 71 % and 64 % amino acid sequence identity with bovine, mouse and rat CXCL17, respectively.

Alternate Names

CXCL17, DMC, VCC-1, VCC1, VCC-1/CXCL17

Gene Symbol

CXCL17

UniProt