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Recombinant Insect 3-Hydroxykynurenine Transaminase Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18167

Novus Biologicals, part of Bio-Techne
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NBP3-18167

Key Product Details

Source

E. coli

Accession #

Conjugate

Unconjugated

Applications

Enzyme Activity

Product Specifications

Description

Full-length 3-HKT (Anopheles gambiae)

Source: E. coli

Uniprot ID: Q7PRG3

Purity

>99%, by SDS-PAGE

Predicted Molecular Mass

44.3 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Activity

Specific activity towards D,L-3-Hydroxykynurenine Transaminase (3HK): 33 umol/min per mg Primarily catalyses the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of 3-hydroxykynurenine (3-HK) to xanthurenic acid (XA)

Application Notes

Can be used to test potential xanthurenic acid synthesis inhibitors, by performing in vitro transamination assays followed by HPLC-UV analysis.

Protein / Peptide Type

Recombinant Protein

Formulation, Preparation and Storage

NBP3-18167
Formulation 20mM TRIS-HCl pH 8.0, 150mM NaCl and 40uM pyridoxal 5'-phosphate (PLP)
Preservative No Preservative
Concentration Please see the vial label for concentration. If unlisted please contact technical services.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.

Background: 3-Hydroxykynurenine Transaminase

The 3-hydroxykynurenine transaminase (3-HKT) gene plays a vital role in the development of malaria parasites by participating in the synthesis of xanthurenic acid, which is involved in the exflagellation of microgametocytes in the midgut of malaria vector species. The 3-HKT enzyme is involved in the tryptophan metabolism of Anophelines. The gene had been studied in the important global malaria vector, Anopheles gambiae.

Alternate Names

3-HKT, Alanine--glyoxylate aminotransferase, EC:2.6.1.63

UniProt

Additional 3-Hydroxykynurenine Transaminase Products

Product Documents for Recombinant Insect 3-Hydroxykynurenine Transaminase Protein

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Recombinant Insect 3-Hydroxykynurenine Transaminase Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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