LY 294002 hydrochloride

Product Description

LY 294002 hydrochloride is a prototypical PI 3-kinase inhibitor (IC₅₀ values are 0.31, 0.73, 1.06 and 6.60 μM for PI 3-Kβ, PI 3-Kα, PI 3-Kδ and PI 3-Kγ respectively). Also inhibits other kinases including, CK2, mTOR, PLK1, PIM1 and PIM3. Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo. Suppresses proliferation of mESCs. Inhibits autophagic sequestration in rat hepatocytes.

Negative Control also available.

Solubility

Preparing Stock Solutions for LY 294002 hydrochloride

The following data is based on the product molecular weight 343.81

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	11.63 mL	58.17 mL	116.34 mL
1.25 mM	2.33 mL	11.63 mL	23.27 mL
2.5 mM	1.16 mL	5.82 mL	11.63 mL
12.5 mM	0.23 mL	1.16 mL	2.33 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bain The selectivity of protein kinase inhibitors: a further update. Biochem.J. 2007 PMID: 17850214
• Blommaart The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur.J.Biochem. 1997 PMID: 9030745
• Lianguzova Phosphoinositide 3-kinase inhibitor LY294002 but not serum withdrawal suppresses proliferation of murine embryonic stem cells. Cell Biol.Int. 2007 PMID: 17321171
• Vlahos A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002). J.Biol.Chem. 1994 PMID: 8106507