Lonafarnib

Tocris Bioscience, part of Bio-Techne | Catalog # 6265

Potent farnesyltransferase inhibitor
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Key Product Details

Description

Potent farnesyltransferase inhibitor

View all Protein Prenyltransferase Inhibitors »

Product Description

Lonafarnib is a potent farnesyl transferase inhibitor (IC50 = 1.9 nM). Inhibits farnesylation of RAS. Also inhibits Pgp transport (IC50 < 3 μM) and increases potency and anticancer activity when used in conjunction with cytotoxic Pgp substrates. Inhibits neovascularization by affecting cell motility. Orally bioavailable.

Product Specifications

Molecular Weight

638.82

Formula

C27H31Br2ClN4O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide

CAS Number

193275-84-2

PubChem ID

148195

InChI Key

DHMTURDWPRKSOA-RUZDIDTESA-N

SMILES

NC(N1CCC(CC1)CC(N2CCC([C@H]3C4=NC=C(C=C4CCC5=CC(Cl)=CC(Br)=C35)Br)CC2)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.39 10

Preparing Stock Solutions for Lonafarnib

The following data is based on the product molecular weight 638.82

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.65 mL 78.27 mL 156.54 mL
0.5 mM 3.13 mL 15.65 mL 31.31 mL
1 mM 1.57 mL 7.83 mL 15.65 mL
5 mM 0.31 mL 1.57 mL 3.13 mL

Calculators

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Product Documents for Lonafarnib

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Lonafarnib

For research use only

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