Ac-RYYRIK-NH2
Tocris Bioscience, part of Bio-Techne | Catalog # 1239
High affinity NOP ligand
Discontinued Product
1239 has been discontinued.
View all NOP Receptor Ligands products.
Product Description
Ac-RYYRIK-NH2 is a high affinity ligand for the NOP site (Ki = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties in vivo, inhibiting locomotor activity in mice.Product Specifications
Molecular Weight
939.12
Formula
C44H70N14O9
Storage
Desiccate at -20°C
CAS Number
200959-48-4
PubChem ID
9963005
InChI Key
WBBBVZGQADABSU-RERZDIOCSA-N
SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CCCCN)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Background References
References are publications that support the biological activity of the product.
- Berger Acetyl-RYYRIK-NH2, a nociceptin/orphanin FQ (noc/OFQ) receptor ligand, exhibits properties of an antagonist and agonist as well. Regul.Pept. 1999 PMID: 10998548
- Dooley Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J.Pharmacol.Exp.Ther. 1997 PMID: 9353393
- Berger Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br.J.Pharmacol. 1999 PMID: 10188961
Product Specific Notices for Ac-RYYRIK-NH2
For research use only
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