NCH 51
Tocris Bioscience, part of Bio-Techne | Catalog # 3747
Histone deacetylase inhibitor
Discontinued Product
3747 has been discontinued.
View all Class I Histone Deacetylases Inhibitors products.
Key Product Details
Description
Histone deacetylase inhibitor
Alternative Names
PTACH
Product Description
NCH 51 is a histone deacetylase (HDAC) inhibitor. Inhibits growth of various cancer cells in vitro (EC50 = 1.1 - 9.1 μM).Product Specifications
Molecular Weight
390.56
Formula
C20H26N2O2S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Methylpropanethioic acid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester
CAS Number
848354-66-5
PubChem ID
11395181
InChI Key
MDYDGUOQFUQOGE-UHFFFAOYSA-N
SMILES
O=C(CCCCCCSC(C(C)C)=O)NC1=NC(C2=CC=CC=C2)=CS1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.06 | 100 | |
| Ethanol | 9.76 | 25 |
Preparing Stock Solutions
for NCH 51
The following data is based on the product molecular weight 390.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.56 mL | 12.80 mL | 25.60 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.12 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.56 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sanda Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells. Leukemia 2007 PMID: 17690692
- Suzuki Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J.Med.Chem. 2005 PMID: 15715470
Product Specific Notices for NCH 51
For research use only
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