Lofepramine

Tocris Bioscience, part of Bio-Techne | Catalog # 2545

5-HT and NA reuptake inhibitor (SNRI)
Discontinued Product
2545 has been discontinued. View all 5-HT Transporter Inhibitors products.

Key Product Details

Description

5-HT and NA reuptake inhibitor (SNRI)

Alternative Names

Lopramine,Leo 640

View all 5-HT Transporter Inhibitors »

Product Description

Lofepramine is a serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine. Produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo.

Product Specifications

Molecular Weight

418.97

Formula

C26H27N2OCl

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz(Z)[b,f]azepin-5-yl)propyl]methylamino]ethanone

CAS Number

23047-25-8

PubChem ID

3947

InChI Key

SAPNXPWPAUFAJU-UHFFFAOYSA-N

SMILES

CN(CCCN1C2=CC=CC=C2CCC2=CC=CC=C12)CC(=O)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.42 75
Ethanol 4.19 10

Preparing Stock Solutions for Lofepramine

The following data is based on the product molecular weight 418.97

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 3.18 mL 15.91 mL 31.82 mL
3.75 mM 0.64 mL 3.18 mL 6.36 mL
7.5 mM 0.32 mL 1.59 mL 3.18 mL
37.5 mM 0.06 mL 0.32 mL 0.64 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Product Documents for Lofepramine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Lofepramine

For research use only

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