BAY 6035
Tocris Bioscience, part of Bio-Techne | Catalog # 6561
Potent and selective SMYD3 inhibitor
Key Product Details
Description
Potent and selective SMYD3 inhibitor
Product Description
BAY 6035 is a potent SMYD3 inhibitor (IC50 = 70 nM for inhibition of MEKK2 methylation in cells). Exhibits >100-fold selectivity for SMYD3 over other histone methyltransferases.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-6035 probe summary on the SGC website.Product Specifications
Molecular Weight
396.48
Formula
C22H28N4O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-1-(3-Azabicyclo[3.1.0]hex-3-ylcarbonyl)-N-(2-cyclopropylethyl)-2,3,4,5-tetrahydro-2-methyl-4-oxo-1H-1,5-benzodiazepine-7-carboxamide
CAS Number
2247890-13-5
PubChem ID
137499231
InChI Key
CKFRXCBNKKOFGO-IGEOTXOUSA-N
SMILES
O=C(NCCC1CC1)C2=CC=C3N([C@H](CC(NC3=C2)=O)C)C(N4CC5CC5C4)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.65 | 100 | |
| Ethanol | 39.65 | 100 |
Preparing Stock Solutions
for BAY 6035
The following data is based on the product molecular weight 396.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.61 mL | 25.22 mL |
| 5 mM | 0.50 mL | 2.52 mL | 5.04 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Product Specific Notices for BAY 6035
For research use only
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