TRAM 34

Tocris Bioscience, part of Bio-Techne | Catalog # 2946

Potent and highly selective KCa3.1 (IK) channel blocker
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Key Product Details

Description

Potent and highly selective KCa3.1 (IK) channel blocker

View all Ca2+-Activated Potassium Channel Blockers »

Product Description

TRAM 34 is a potent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.

Product Specifications

Molecular Weight

344.84

Formula

C22H17ClN2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

CAS Number

289905-88-0

PubChem ID

656734

InChI Key

KBFUQFVFYYBHBT-UHFFFAOYSA-N

SMILES

ClC(C=CC=C4)=C4C(N2C=CC=N2)(C3=CC=CC=C3)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.45 10 with gentle warming

Preparing Stock Solutions for TRAM 34

The following data is based on the product molecular weight 344.84

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.00 mL 144.99 mL 289.99 mL
0.5 mM 5.80 mL 29.00 mL 58.00 mL
1 mM 2.90 mL 14.50 mL 29.00 mL
5 mM 0.58 mL 2.90 mL 5.80 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for TRAM 34

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TRAM 34

For research use only

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