Apamin

Tocris Bioscience, part of Bio-Techne | Catalog # 1652

KCa2 (SK) channel blocker
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Key Product Details

Description

KCa2 (SK) channel blocker

View all Ca2+-Activated Potassium Channel Blockers »

Product Description

Apamin is a potent and highly selective inhibitor of small-conductance Ca2+-activated K+-channels (KCa2, SK) (IC50 values are 87.7 pM, 2.3 nM and 4.1 nM for KCa2.2, KCa2.3 and KCa2.1 channels, respectively). Reduces release and mRNA expression of inflammatory cytokines TNFα and IL-6. In models of kidney and cardiovascular disease apamin ameliorates tissue injury and dysfunction. Brain penetrant, blocks medium after-hyperpolarization in vitro, reduces neuroinflammation, increases microglia node contacts and Purkinje cell instananeous firing frequency.

Product Specifications

Molecular Weight

2027.34

Formula

C79H131N31O24S4

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

24345-16-2

PubChem ID

16133797

InChI Key

YVIIHEKJCKCXOB-STYWVVQQSA-N

SMILES

[H]N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC2=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC2=CNC=N2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Apamin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Apamin

For research use only

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