Non-species specific IgM Isotype Control (PFR-03)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-62224

Novus Biologicals, part of Bio-Techne
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NBP2-62224
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Key Product Details

Species Reactivity

Human (Negative), Mouse (Negative), Non-species specific, Porcine (Negative), Rat (Negative)

Applications

ELISA, Flow (Cell Surface), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgM Clone # PFR-03

Concentration

Please contact technical services for concentration.

View all IgM Isotype Controls »

Product Specifications

Clonality

Monoclonal

Host

Mouse

Isotype

IgM

Scientific Data Images for Non-species specific IgM Isotype Control (PFR-03)

Mouse IgM Isotype Control (PFR-03) [NBP2-62224] - Example of nonspecific mouse IgM (PFR-03; purified, GAM-APC) signal on human peripheral blood; surface staining, 6 ug/ml.
Mouse IgM Isotype Control (PFR-03) [NBP2-62224] - Example of nonspecific mouse IgM (PFR-03) FITC signal on human peripheral blood; surface staining, 1 ug/ml.
Mouse IgM Isotype Control (PFR-03) [NBP2-62224] - Example of nonspecific mouse IgM (PFR-03) PE signal on human peripheral blood; surface staining, 3 ug/ml.

Applications for Non-species specific IgM Isotype Control (PFR-03)

Application
Recommended Usage

Flow Cytometry

1:10-1:1000

Formulation, Preparation, and Storage

Purification

Multi-step

Formulation

Tris buffered saline (TBS), pH 8.0

Preservative

15mM Sodium Azide

Concentration

Please contact technical services for concentration.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: IgM

IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to its large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to its high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.

Long Name

Immunoglobulin M

Alternate Names

AGM1, DKFZp686I15196, DKFZp686I15212, FLJ00385, immunoglobulin heavy constant mu, MGC104996, MGC52291, MU, VH

Gene Symbol

IGHM

Additional IgM Products

Product Documents for Non-species specific IgM Isotype Control (PFR-03)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Non-species specific IgM Isotype Control (PFR-03)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Isotype Controls are guaranteed for 1 year from date of receipt.

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