NNC 711

Tocris Bioscience, part of Bio-Techne | Catalog # 1779

Selective GAT-1 inhibitor
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Key Product Details

Description

Selective GAT-1 inhibitor

View all GABA Transporter Inhibitors »

Product Description

NNC 711 is a potent and selective inhibitor of GABA uptake by GAT-1 (IC50 values are 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Anticonvulsant following systemic administration in vivo. Also exhibits cognition-enhancing activity.

Product Specifications

Molecular Weight

386.88

Formula

C21H22N2O3.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride

CAS Number

145645-62-1

PubChem ID

123738

InChI Key

YZYRTEYMUTWJPL-UHFFFAOYSA-N

SMILES

O=C(C1=CCCN(CCO/N=C(C3=CC=CC=C3)/C2=CC=CC=C2)C1)O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.87 10
DMSO 38.69 100

Preparing Stock Solutions for NNC 711

The following data is based on the product molecular weight 386.88

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.58 mL 12.92 mL 25.85 mL
5 mM 0.52 mL 2.58 mL 5.17 mL
10 mM 0.26 mL 1.29 mL 2.58 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for NNC 711

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NNC 711

For research use only

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