TokeOni

Name: TokeOni
Brand: Tocris Bioscience
SKU: 6555

Tocris Bioscience a Bio-Techne Brand

Catalog # 6555

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Key Product Details

Description:	NIR-emission luciferin analog; ideal for deep tissue applications; orally bioavailable and brain penetrant
Alternative Names:	AkaLumine HCl
Chemical Name:	(4S)-2-[(1E,3E)-4-[4-(Dimethylamino)phenyl]-1,3-butadien-1-yl]-4,5-dihydro-4-thiazolecarboxylic acid hydrochloride
Purity:	≥90% (HPLC)

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Biological Activity for TokeOni

TokeOni is a near-infrared red (NIR)-emission luciferin analog. Peak luminescence at 677 nM. ~40-fold brighter than the luciferin-luciferase system in vitro, and 100-1000 times brighter in vivo. Allows non-invasive visualization of single cells deep inside freely moving animals. Ideal for deep tissue applications. Water soluble (

This product is supplied as a hydrochloride salt, the stoichiometry of which is batch dependant. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

Optical Data for TokeOni

Emission Color	Near-IR
λ_em	677 nm
Application	BLI, BTI, Deep tissue applications

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Technical Data for TokeOni

Formula	C₁₆H₁₈N₂O₂S.xHCl
Storage	Store at -20°C
Purity	≥90% (HPLC)
PubChem ID	124203055
InChi Key	PZCNKVAGZCXXHX-SSRSOBHISA-N
Smiles	CN(C1=CC=C(C=C1)/C=C/C=C/C2=N[C@@H](C(O)=O)CS2)C.Cl
M. Wt	302.39 (Free Base)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TokeOni

Solubility

Soluble to 5mg/ml in water with gentle warming and to 10mg/ml in DMSO

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References for TokeOni

References are publications that support the biological activity of the product.

Nasu Unnaturally aglow with a bright inner light. Science 2018 PMID: 29472468
Iwano Single-cell bioluminescence imaging of deep tissue in freely moving animals. Science 2018 PMID: 29472486
Kuchimaru A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging. Nat. Commun. 2016 PMID: 27297211

Citations for TokeOni

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