Taxol Janelia Fluor® 526
Tocris Bioscience, part of Bio-Techne | Catalog # 7315
Green-fluorescent taxol derivative; binds microtubules. Used for: microtubules imaging. Application: confocal microscopy, super resolution microscopy. Suitable for live cell imaging
Key Product Details
Description
Green-fluorescent taxol derivative; binds microtubules. Used for: microtubules imaging. Application: confocal microscopy, super resolution microscopy. Suitable for live cell imaging
Alternative Names
Janelia Fluor 526-TXL
Product Description
Key information: Taxol Janelia Fluor® 526 is a fluorogenic, green-fluorescent taxol derivative for direct imaging of the microtubule cytoskeleton. Suitable for live cell imaging.Used for: direct imaging of the microtubule cytoskeleton.
Application: confocal microscopy, Super Resolution Microscopy (SRM) including STED.
Properties and Photophysical Data: Taxol Janelia Fluor® 526 is fluorogenic: it fluoresces only once bound to microtubules, enabling hassle-free no-wash experiments. Excitation and emission maxima (λ) are 531 nm and 549 nm, respectively; quantum yield = 0.87; extinction coefficient = 118,000 M-1cm-1.
Licensing Information
Sold under license from the Howard Hughes Medical Institute, Janelia Research CampusOptical Data
| Emission Color | Yellow |
| λabs | 531 nm |
| λem | 549 nm |
| Extinction Coefficient (ε) | 118000 M-1cm-1 |
| Quantum Yield (φ) | 0.87 |
| Application | Confocal Microscopy, Super Resolution Microscopy (SRM), STED |
Spectra Viewer
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Product Specifications
Molecular Weight
1507.42
Formula
C73H74F6N4O17.CF3CO2H
Storage
Store at -20°C
Purity
≥85% (HPLC)
Chemical Name
4-((8-(((1S,2R)-3-(((2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-12-(benzoyloxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-9-yl)oxy)-2-hydroxy-3-oxo-1-phenylpropyl)amino)-8-oxooctyl)carbamoyl)-2-(3-(3,3-difluoroazetidin-1-ium-1-ylidene)-6-(3,3-difluoroazetidin-1-yl)-2,7-difluoro-3H-xanthen-9-yl)benzoate trifluoroacetate
CAS Number
2410613-93-1
InChI Key
WYTXGBVNWCQFKK-SOCHEKDQSA-N
SMILES
[H][C@@]12C[C@@H]([C@]3(C([C@@H](C4=C([C@@H](OC([C@@H]([C@H](C5=CC=CC=C5)NC(CCCCCCCNC(C6=CC(C7=C8C=C(/C(C=C8OC9=C7C=C(C(N%10CC(F)(C%10)F)=C9)F)=[N+]%11CC(F)(C/%11)F)F)=C(C([O-])=O)C=C6)=O)=O)O)=O)C[C@@]([C@H]([C@@]3([C@]1(OC(C)=O)CO2)[H])OC(C%12=CC=CC=C%12)=O)(C4(C)C)O)C)O)=O)C)O.O=C(O[H])C(F)(F)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.07 | 10 |
Preparing Stock Solutions
for Taxol Janelia Fluor® 526
The following data is based on the product molecular weight 1507.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 6.63 mL | 33.17 mL | 66.34 mL |
| 0.5 mM | 1.33 mL | 6.63 mL | 13.27 mL |
| 1 mM | 0.66 mL | 3.32 mL | 6.63 mL |
| 5 mM | 0.13 mL | 0.66 mL | 1.33 mL |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Zheng Rational design of fluorogenic and spontaneously blinking labels for super-resolution imaging. ACS Cent.Sci. 2019 PMID: 31572787
Product Specific Notices for Taxol Janelia Fluor® 526
For research use only
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