BromoCatch™ Ligand, TCO

Tocris Bioscience, part of Bio-Techne | Catalog # 9036

Clickable TCO-functionalized covalent probe for BromoCatch-tagged proteins
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Key Product Details

Description

Clickable TCO-functionalized covalent probe for BromoCatch-tagged proteins

View all BromoCatch Platform Fluorescent Probes and Dyes »

Product Description

BromoCatch™ Ligand, TCO is a covalent ligand engineered to irreversibly bind BromoCatch-tagged proteins via selective reaction with the E438C cysteine mutant of the Brd4-BD2 domain. Featuring a TCO handle appended to the BromoCatch Ligand scaffold, this ligand enables downstream modification through copper-free bioorthogonal reaction based on the ultrafast inverse electron-demand Diels-Alder (IEDDA) cycloaddition between TCO and tetrazine derivatives. BromoCatch™ Ligand, TCO facilitates modular tagging of BromoCatch fusions with fluorophores, biotin, affinity tags, or functional moieties, offering a flexible platform for custom probe development. It enables site-specific protein labeling in vitro and is ideal for applications in chemical biology, proteomics, and multiplexed detection assays.

Please refer to this protocol for further information on how to use this product.

This product is part of an early adopter program.

BromoCatch™ is a trademark of Bio-Techne Corp.

Licensing Information

Sold under exclusive licence from the University of Dundee

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Product Specifications

Molecular Weight

763.93

Formula

C39H50FN7O6S

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(E)-Cyclooct-4-en-1-yl (2-(2-(2-((R)-2-((S)-4-(4-(2-fluoroacrylamido)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)butanamido)ethoxy)ethoxy)ethyl)carbamate

InChI Key

XMLKOEDHEFGLGA-FOJYLCAGSA-N

SMILES

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)NC(C(F)=C)=O)=N[C@@H]([C@H](C(NCCOCCOCCNC(OC4CCC/C=C/CC4)=O)=O)CC)C5=NN=C(C)N25

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for BromoCatch™ Ligand, TCO

Certificate of Analysis

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Product Specific Notices for BromoCatch™ Ligand, TCO

For research use only

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